DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	783	Identity:	182/783 - (23%)
Similarity:	311/783 - (39%)	Gaps:	174/783 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGAILFS--ICAIDASVPHPLAANYSIDIL--------------RLAKAAHIKAYMGDEKEQAC 57
            ||..::|:  :|||.|::   ||..|...:.              ..|:||...|...|.....|
Human    62 LLSGLVFAAGLCAILAAM---LALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPC 123

  Fly    58 NNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSCR 122
            .:||::||..|.|.|.....|.....:..:.|....:...:|.....|...:|.|:::.|:.||.
Human   124 QDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCL 188

  Fly   123 LQTNDTRSALNTLQNVTDFRGGW--------PEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGL 179
            ......|.....:..|.:..|||        |.: .|.|     |..:::...:..........|
Human   189 DMREIERLGPRPMLEVIEDCGGWDLGGAEERPGV-AARW-----DLNRLLYKAQGVYSAAALFSL 247

  Fly   180 EVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREI---YERSIENKLKLYFPEQSEHWRQE 241
            .|.||.:....:.::|......:..|.......|.:.:|   |...:|..|.|...:..|    :
Human   248 TVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVE----Q 308

  Fly   242 VASQVVQIEQQLAKGLPHNPALTLAQ-TTRQRTAAEM--KTAYGSYVDVTRYLQ---LIFNDNLY 300
            .|.:::|:|||||.       :|::: ...:|..:.|  |...|....:|.:|:   |:  |.::
Human   309 KAQEILQVEQQLAN-------ITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLL--DQIF 364

  Fly   301 MDLYETPE-------DYMSNLVDVIRETPKLQLANYTMWKAL------------EAL-------- 338
            .:.:...|       |||..:..:||.||...|.||.:|:.:            |||
Human   365 QEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEME 429

  Fly   339 ------DIARVPASQRADIWCVQLAQQFFPHQLESLF-HRNYNHMQMINELQSTWSDIKRVFRED 396
                  ::|||         |:..|.:.|...|.:|| |.:::..... ::|....|||.:..:.
Human   430 GSDKPQELARV---------CLGQANRHFGMALGALFVHEHFSAASKA-KVQQLVEDIKYILGQR 484

  Fly   397 LQASERLLWLTLETRQKAITKLEAL------------------KLHFRTHDDNKLIRQMHGLILN 443
            |   |.|.|:..|||..|..||:.:                  :..|..|:..
Human   485 L---EELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKT------------ 534

  Fly   444 MDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP------HYEIQKNRIQVPITFLQARFFW 502
               ::.|:::.:::..|..:.|:..|  .:.....||      :|...||::..|...||...:
Human   535 ---YFKNILNSIRFSIQLSVKKIRQE--VDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLY- 593

  Fly   503 DPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV 567
            ||.:|..|.|..:|.::..::.||:|..|.:||..|...:||...|.|.:.|:.:|....|..|.
Human   594 DPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFT 658

  Fly   568 EYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLK-NAAETPVIYQRERLPLLDHDHNQIFYLGY 631
            .|..: |..|..|...:||.|.|.:||.|||:|:: :..|.|       ||.|.:.|:|:|::.:
Human   659 VYNQR-VNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHP-------LPRLKYTHDQLFFIAF 715

  Fly   632 AQLYC-------------TDYPETVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKC 683
            ||.:|             ||        ...||..||..::|..::|..|:.|.::..:|...||
Human   716 AQNWCIKRRSQSIYLQVLTD--------KHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKC 772

  Fly   684 TLY 686
            :::
Human   773 SVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	166/715 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	164/708 (23%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	166/718 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150983
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850