DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and ece2b

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_017206531.1	Gene:	ece2b / 793465	ZFINID:	ZDB-GENE-131120-140	Length:	794	Species:	Danio rerio

Alignment Length:	776	Identity:	183/776 - (23%)
Similarity:	325/776 - (41%)	Gaps:	143/776 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLLLGAILFSI-CAIDASVPHPLAANYSIDILR--------LAKAAHIKAYMGDEKEQACNNFYN 62
            ||||.::|... ||:      .|...|:.|..|        :..|:.|...: |.....|.:||.
Zfish    66 GLLLASLLALFGCAV------TLGVRYNRDPARSICLTEACVTVASKIVEAL-DRSADPCQDFYQ 123

  Fly    63 YACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTND 127
            |||..|.|.:|....::|.:....:.:........:|::.|..:.:.|:|:.:.:|.||..:...
Zfish   124 YACGGWVRKNPLPDGRSRWSTFNSIWDQNQAVLKHLLENGTFNSSSEAERKTQSYYLSCLNEQRI 188

  Fly   128 TRSALNTLQNVTDFRGGWPEIRVASWYQYEY-DWLQVVANLKRKLGVDIFIGLEVILDYKEEKMH 191
            .......|.::....|||.  ...||.:..: |.|::::...|   ...|..:.|.:|.|....:
Zfish   189 EELGAQPLMDLITKIGGWN--ITESWDKENFLDVLKIISGPYR---AQPFFTVSVSVDPKNSNSN 248

  Fly   192 RLKIG-APQFPMSRRHYLHPHFEGTREIY-ERSIENKLKLYFPEQSEHWRQEVASQVVQIEQQLA 254
            .:::. :..|..||.:||:...|...:.| :..:|..|.|...:.|...:.:   |::..|..||
Zfish   249 VIQVDQSGLFLPSRDYYLNKTNEKVLKAYLDYMVELGLLLGGDKNSTRGQMQ---QILDFETALA 310

  Fly   255 KGLPHNPALTLAQTTRQR--------TAAEMKTAYGSYVDVTRYLQ-----LIFNDNLYMDLYET 306
            .       :|:.|..|:.        |.|::: .....::...||.     |..||...:.:|
Zfish   311 N-------ITVPQDERRDEEKIYHKITIADLQ-VLAPAIEWLDYLNSVLSPLELNDTEPVVVY-- 365

  Fly   307 PEDYMSNLVDVIRETPKLQLANYTMW-------------------KALEALDIARVPASQRADIW 352
            .::||..:.::|.:|....|.||.:|                   |.||:|...:...:.|   |
Zfish   366 AKEYMQQVSELINKTDHSLLNNYMIWNLVQKGASSLDQRFENAQDKLLESLYGTKKSCTPR---W 427

  Fly   353 --CVQLAQQFFPHQLESLF-----------------------HRNYNH------MQMINELQSTW 386
              |:..........|.:||                       .||.|.      ..:|.:.:...
Zfish   428 QTCIGNTDDTLGFALGALFVKATFDKQSKEIDLNGGAFLPSCGRNVNSTVHNLMFSVITQAEGMI 492

  Fly   387 SDIKRVFREDLQASERLLWLTLETRQKAITKLEALKLHFRTHD---------DNKLIRQMH-GLI 441
            ::|:..|:   .|.:.|.|:..:|||.|..|.:|:      :|         |:|.:..:: |..
Zfish   493 NEIRTAFK---GALDDLKWMDEQTRQAAKDKADAI------YDMIGFPDFILDSKELDDVYDGYE 548

  Fly   442 LNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFF 501
            :..|.|:.|:::...: :.|.:|..:.:|...|:....|     :|...||.|..|...|||.|:
Zfish   549 VTEDNFFQNMINFYNF-SARVMADQLRKPPNRDQWSMTPPTVNAYYMPTKNGIVFPAGILQAPFY 612

  Fly   502 WDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIF 566
            ... :|..|.:..:||::..::.|.||..||.||..|...:||.::|..::..||:|..:||..:
Zfish   613 AQD-HPKALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRSWWQNSSVEAFKNRTECMVDQYTQY 676

  Fly   567 VEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWL-KNAAETPVIYQRERLPLLDHDHNQIFYLG 630
            . ..|:.:..|..|...:||||.|..||.||:.|: ||..|       :|||.::..::|:|::|
Zfish   677 T-INGEHINGKQTLGENIADNGGLKAAYHAYRSWVQKNGEE-------KRLPAVNLTNDQLFFVG 733

  Fly   631 YAQLYCT-DYPETVER----FDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :||::|: ..||:...    ....|.:.||...||||.:||..:.|.....:|:..:|.::
Zfish   734 FAQVWCSVRTPESAHEGLMTDPHSPPKYRVIGTLSNSPEFAEHFQCPLGSSMNSGHRCEVW 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	168/713 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	167/706 (24%)
ece2b	XP_017206531.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585578
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950