DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	786	Identity:	177/786 - (22%)
Similarity:	310/786 - (39%)	Gaps:	180/786 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGAILFS--ICAIDASVPHPLAANYSIDIL-------------------RLAKAAHIKAYMGDE 52
            ||..::|:  :|||       |||..::..|                   ..|:||...:...|.
  Rat    62 LLSGLVFAAGLCAI-------LAAMLALKYLGPGAAGTGGACPEGCPERKAFARAARFLSANLDA 119

  Fly    53 KEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYF 117
            ....|.:||::||..|.|.|.....|.....:..:.|....:...:|...|.|...:|.|:::.|
  Rat   120 SIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAF 184

  Fly   118 YGSCRLQTNDTRSALNTLQNVTDFRGGW------PEIRVASWYQYEYDWLQVVANLKRKLGVDIF 176
            :.||.......|.....:..|.:..|||      .....|.|     |..:::...:........
  Rat   185 FRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARW-----DLNRLLYKAQGVYSAAAL 244

  Fly   177 IGLEVILDYKEEKMHRLKIGAPQFPMSRRH-YLHPHFEGTREI--YERSIENKLKLYFPEQSEHW 238
            ..|.|.||.:....:.::|......:..|. ||....|..:.:  |:..:|..|:|...:..|
  Rat   245 FSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFMERLLRLLGADAVE-- 307

  Fly   239 RQEVASQVVQIEQQLAKGLPHNPALTLAQ---TTRQRTAAEMKTAYGSYVDVTRYLQ---LIFND 297
              :.|.:::|:||:||.       :::::   ..|..::...|...|....:|.:||   |:  |
  Rat   308 --QKAQEILQLEQRLAN-------ISVSEYDDLRRDVSSVYNKVTLGQLQKITPHLQWKWLL--D 361

  Fly   298 NLYMDLYETPE-------DYMSNLVDVIRETPKLQLANYTMWKAL------------EAL----- 338
            .::.:.:...|       |||..:..:||.||:..|.||.:|:.:            |||
  Rat   362 QIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAK 426

  Fly   339 ---------DIARVPASQRADIWCVQLAQQFFPHQLESLF-HRNYNHMQMINELQSTWSDIKRVF 393
                     ::|||         |:..|.:.|...|.:|| |.:::..... ::|....|||.:.
  Rat   427 EMEGNDKPQELARV---------CLGQANRHFGMALGALFVHEHFSAASKA-KVQQLVEDIKYIL 481

  Fly   394 REDLQASERLLWLTLETRQKAITKLEAL------------------KLHFRTHDDNKLIRQMHGL 440
            .:.|   |.|.|:..:|:..|..||:.:                  :..|..|:..
  Rat   482 GQRL---EELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKT--------- 534

  Fly   441 ILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP------HYEIQKNRIQVPITFLQAR 499
                  ::.|:::.:::..|..:.|:..|  .:.....||      :|...||::..|...||..
  Rat   535 ------YFKNILNSIRFSIQLSVKKIRQE--VDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPT 591

  Fly   500 FFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYA 564
            .: ||.:|..|.|..:|.::..::.||:|..|.:||..|...:||...|.|.:..:.:|....|.
  Rat   592 LY-DPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRLYD 655

  Fly   565 IFVEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLK-NAAETPVIYQRERLPLLDHDHNQIFY 628
            .|..|..: |..|..|...:||.|.|.:||.|||:|:: :..|.|       |..|.:.|||:|:
  Rat   656 NFTVYNQR-VNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHP-------LHRLKYTHNQLFF 712

  Fly   629 LGYAQLYC-------------TDYPETVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNAR 680
            :.:||.:|             ||        ...||..||..::|..::|..|:.|.::..:|..
  Rat   713 IAFAQNWCIKRRSQSIYLQVLTD--------KHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPV 769

  Fly   681 FKCTLY 686
            .||:::
  Rat   770 HKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	162/713 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	160/706 (23%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	162/716 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344507
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850