DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and mmel1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_017213856.1	Gene:	mmel1 / 560703	ZFINID:	ZDB-GENE-101112-2	Length:	765	Species:	Danio rerio

Alignment Length:	720	Identity:	186/720 - (25%)
Similarity:	310/720 - (43%)	Gaps:	130/720 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DEKEQACNNFYNYACANWPRLH--PARKS-KTRTNYLEELQELYIRKSADMLKSATRGAENSADR 112
            |.....|.|||.|||..|...|  |...| .:..|.|.:..|:.::...:|        ||..||
Zfish    92 DPSVDPCQNFYQYACGGWIERHVIPETSSLHSVFNILRDELEIVLKGVLEM--------ENKDDR 148

  Fly   113 Q----LKYFYGSCR----LQTNDTRSALNTLQNVTDFRGGWPEIRVAS--W-------YQYEYDW 160
            :    .|..|.||.    ::..|::..|..:.::    |.||   |||  |       :..| |.
Zfish   149 EAFKKAKTLYSSCMNEILIEQRDSQPLLRLIDSI----GDWP---VASEVWNGTSEQTWSLE-DT 205

  Fly   161 LQVVANLKRKLGVDIFIGLEVIL--DYKEEKMHRLKIGAPQFPM-SRRHYLHP-HFEGTREIYER 221
            |.|:.....|..|     ||:.:  |.::...:.:.:..|...| ||.:||.. :::..||.|..
Zfish   206 LAVLNGRYNKKAV-----LEMFVWPDDRDSSRYIIHVDQPALGMPSRDYYLSDGNYKKVREAYLE 265

  Fly   222 SIENKLKLYFPE----QSEHWRQEVASQVVQIEQQLAKGL----PHNPALTLAQTTRQRTAAEMK 278
            .:.:..::...:    |.|....|..|||:::|..:|...    ..|....|......|.|.:..
Zfish   266 FMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEERNDITVLYNKMTLREAQQTF 330

  Fly   279 TAYGSYVDVTRYLQLIFND---NLYMD----LYETPEDYMSNLVDVIRETPKLQLANYTMWKALE 336
            ...|  .:.|||:|.|.:.   ::..|    :|.:|  |:..|.:|:.:.....|.||.:|
Zfish   331 NLNG--FNWTRYIQGIMSSVSISVQSDEPIVIYCSP--YLEKLSEVLSKHSHRTLQNYLVW---- 387

  Fly   337 ALDIARVPASQR--ADI-----------------W--CVQLAQQFFPHQLESLFHR---NYNHMQ 377
            .|.:.||.:..|  .|:                 |  ||:..|....:.:.:|:.|   :.|..:
Zfish   388 MLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEARWRDCVRYVQGNMENAVGALYVRETFSGNSKR 452

  Fly   378 MINELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEALKL------HFRTHDDNKLIRQ 436
            |:.||      ||::....::..|.|.|:..:::.||..|..|:..      |....::.||.::
Zfish   453 MVGEL------IKKIQEAYVETLEELSWMDEQSKVKAREKAMAISEQIGYPDHILEEENKKLDQE 511

  Fly   437 MHGLILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAED-------EVHKLPHYEIQKNRIQVPIT 494
            ...|..:.:.::.|::..|....|:|..|| .|||..|       .|:..  |...:|:|..|..
Zfish   512 YAHLNFSEENYFENILENLAASAQKGHKKL-REPVDPDMWIIGAAVVNAF--YSHNRNQIVFPAG 573

  Fly   495 FLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCF 559
            .||..||.:... ..|.:..:|:::..::.||||..||.:|..|...|||.:.|...:..:::|.
Zfish   574 ILQPPFFSEKQL-QALNFGGIGMVIGHEITHGFDDHGRNFDKDGNMYNWWSNYSAERFEDQSKCM 637

  Fly   560 QEQYAIFVEYK---GKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDH 621
            .|||..| .:|   |:.|.....|...:||||.:..||:||.:|::...|.|      |||.||.
Zfish   638 VEQYGRF-SWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVEREGEEP------RLPGLDM 695

  Fly   622 DHNQIFYLGYAQLYC----TDYP-ETVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARF 681
            :|.|:|:|.:||::|    .:|. :|::.....|.:.||..:|.|.:.|:.|:.|:|...:|...
Zfish   696 NHKQLFFLNFAQVWCGACRPEYAIQTIKTDPHSPLEYRVLGSLQNFEAFSEAFHCARGAPMNPEE 760

  Fly   682 KCTLY 686
            ||.::
Zfish   761 KCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	184/710 (26%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	182/703 (26%)
mmel1	XP_017213856.1	PepO	88..765	CDD:226118	186/718 (26%)
mmel1	XP_017213856.1	M13	95..763	CDD:189000	184/713 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950