DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and PHEX

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	785	Identity:	189/785 - (24%)
Similarity:	316/785 - (40%)	Gaps:	172/785 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLGAILFSI-------------C----AIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQ 55
            |:||.|||.:             |    .|:|:.......|.|:|
Human    31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVD-------------------- 75

  Fly    56 ACNNFYNYACANWPRLHPARKSK--------TRTNYLEELQELYIRKSADMLKSATRGAENSADR 112
            .|:||:.:||..|...:|..:..        .|.|...:|:||       :.||.:|..:..|.:
Human    76 PCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKEL-------LEKSISRRRDTEAIQ 133

  Fly   113 QLKYFYGSC----RLQTNDTRSALNTLQNVTDFRGGWPEIR-----VASWYQYEYDWLQVVANLK 168
            :.|..|.||    .::..|.:..|:.|:: :.||  ||.:.     ...|.:.::..||.:|..:
Human   134 KAKILYSSCMNEKAIEKADAKPLLHILRH-SPFR--WPVLESNIGPEGVWSERKFSLLQTLATFR 195

  Fly   169 RKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFPMS-RRHYLHPHFEGTR---EIYERSIENKLKL 229
            .:....:||.|.|..|.|....|.||:......:: |..||....|...   .:|:..::..:.|
Human   196 GQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLL 260

  Fly   230 -YFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQL 293
             ....::||..:.|....::|.:.:   :||....:.|...:. ..:|:......: |...|::.
Human   261 GANSSRAEHDMKSVLRLEIKIAEIM---IPHENRTSEAMYNKM-NISELSAMIPQF-DWLGYIKK 320

  Fly   294 IFNDNLYMDLYE-TPED--------YMSNLVDVIRETPKLQLANYTMWKALEALDIARVP-ASQR 348
            :.:..||..|.: :|.:        |..:|..::....|..:|||.:|:.:    .:|:| .|:|
Human   321 VIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMV----YSRIPNLSRR 381

  Fly   349 ADI------------------W--CVQLAQQFFPHQLESLFHRNY---NHMQMINELQS--TWSD 388
            ...                  |  ||...:...|:.:..:|...|   :..:|:.||..  .|:.
Human   382 FQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAF 446

  Fly   389 IKRVFREDLQASERLLWLTLETRQKAITKLEAL--KLHF------RTH--DDNKLIR-------- 435
            |..:.:|:       .|:...|::||..|..|:  |:.:      .||  :|.|.|:
Human   447 IDMLEKEN-------EWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFG 504

  Fly   436 ---QMHGLILNMDRFY-PNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLPHYEIQKNRIQVPITFL 496
               |....:...|.|: ...|...:|         .|.|...:     ..|....|:|:.|...|
Human   505 NVLQTRKYLAQSDFFWLRKAVPKTEW---------FTNPTTVN-----AFYSASTNQIRFPAGEL 555

  Fly   497 QARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQE 561
            |..|||...||..|.|..:||::..:..||||..||:||..|..:.||...||..:..:|:|...
Human   556 QKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMIN 620

  Fly   562 QYAIFVEYK-GKPVQDKDLLRRIVADNGALDIAYRAYQQWL---KNAAETPVIYQRERLPLLDHD 622
            ||:.:...| |..|:.|..|...:||||.|..|:|||::|:   :...|.|:      ||.:...
Human   621 QYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPL------LPGITFT 679

  Fly   623 HNQIFYLGYAQLYCTDY-PETVERFDEL----PEQLRVNTALSNSQQFANAYGCSREEKLNARF- 681
            :||:|:|.||.:.|..| ||......::    |.|.|||.|:||.::|..|:.|.....:|...
Human   680 NNQLFFLSYAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMD 744

  Fly   682 KCTLY 686
            .|.|:
Human   745 SCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	175/715 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	174/707 (25%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	176/738 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920