DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and Nep7

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_651603.1	Gene:	Nep7 / 43356	FlyBaseID:	FBgn0039564	Length:	717	Species:	Drosophila melanogaster

Alignment Length:	767	Identity:	175/767 - (22%)
Similarity:	311/767 - (40%)	Gaps:	189/767 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AILFSICAI----------DASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNYACA 66
            |:...||.|          |.|..:.: .:.:.|.|| :..|.:|:||....: .|::||.:||.
  Fly    17 AVCILICVILNDCEARSIGDESHENAI-TDETADYLR-SHGAMMKSYMNFSVD-PCDDFYEFACG 78

  Fly    67 NW-----PRLHPARKSK----------------TRTNYLEELQELYIRKSADMLKSATRGAENSA 110
            ||     ||..|.|:|.                |||...|.|     ..||::|.:
  Fly    79 NWKNVKTPRQSPHRRSNILDISYTLMDVTEQLLTRTKLAEAL-----NVSAELLVA--------- 129

  Fly   111 DRQLKYFYGSCRLQTNDTRSA-----LNTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRK 170
                :.||.||.......|.|     |:.::::    ||:|.:...:|....:.|..:.|:|. .
  Fly   130 ----QRFYNSCLAAELFPRPAADPAYLSVIRSL----GGFPAVDRDAWNASSFSWFNMSAHLS-N 185

  Fly   171 LGVDIFIGLEVILDYKEEKMHRLKIGAPQFP---------MSRRHYLH-PHFEGTREIYERSIEN 225
            .||...|..|::               ||.|         :...|.:| .|...|.....:..|:
  Fly   186 YGVRSLIHEEIL---------------PQHPFNPYFKLPELGFDHVVHTAHVANTSSRAYQLNEH 235

  Fly   226 KLKLYFPEQSEHWRQEVA----------SQVVQIEQQLAKGLPHNPALTLAQTTRQR----TAAE 276
            :::.|..|.: ..:.|::          |:.:.||.:.             ::.|.:    :..|
  Fly   236 RMRGYLKEYN-LTKDEISAVIEGVFAFWSEALSIEDKF-------------ESDRDKCDLLSEIE 286

  Fly   277 MKTAYGSYVDVTRYLQLIFNDNLYMDLYETPE-----DYMSNLVDVIRETPKLQLANYTMWKALE 336
            ....:|.:   ..|.::.:|.   :|.|....     |:....:|.:.......:|||...:.|.
  Fly   287 EVPRFGQW---RSYYEIAWNG---IDFYNGSSGGEFCDFYYVELDKVCAKHTEAVANYLAMRFLY 345

  Fly   337 ALD----IARVPASQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFRE-D 396
            .:|    ..:.|..|:.:  |:.:.|...|    :||:|.|......:|..|..||:....|: .
  Fly   346 RMDDKLKEPKQPEDQKVN--CLMIVQMTLP----NLFNRLYMAEHFTDEKHSEISDMVTEMRKAQ 404

  Fly   397 LQASERLLWLTLETRQKAITKLEALKLHFRTHDDNK----LIRQMHGLILNMDRFYPNLVS--VL 455
            .|..|.:.||..|||.:|::|...:.....::.:.:    |||:::.|.:....:..:|::  ||
  Fly   405 RQILESVEWLDAETRAEALSKEAGITPVIGSYKNEELSDTLIREINNLTIVEGSYAQSLINLRVL 469

  Fly   456 QWKTQRGLAKLMTEPVAED----------EVHKLPHYEIQKNRIQVPITFLQARFFWDPAY---- 506
            .....| .|.|..:.:.:|          :|:.. :|.:..:      .::.|.....|||
  Fly   470 GTYLHR-YAGLHADELPKDTKPLTLLVGMQVNAF-YYNLDNS------VYVMAGVLHPPAYHRSW 526

  Fly   507 PNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV---- 567
            |:.||:.|:|.|:..::.||||..|..:|:.|...:||...||:.:..|.||:.:.:..::
  Fly   527 PDSLKFGTIGYLIGHELTHGFDTEGSSFDSAGEVRDWWSRKSEAVFQERAQCYVDYFNQYLIPEI 591

  Fly   568 --EYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNA------AETPVIYQRERLPLLDHDHN 624
              ..:|...:|::     :||.|.|..|...|:..:|..      .|| :.::.|::|.||....
  Fly   592 NQTIRGNETRDEN-----IADAGGLRAALTGYRNHMKQLQRSGADGET-LAHKNEQMPGLDLSPE 650

  Fly   625 QIFYLGYAQLYCTDYPETVERFDELP-----EQLRVNTALSNSQQFANAYGC 671
            |:|::|:|||:|.|| |....::||.     ::.||..|:||:..||..|.|
  Fly   651 QLFFVGFAQLWCADY-EPEHYWEELTGAHTVDKYRVLGAVSNNDDFAEVYKC 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	162/712 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	162/712 (23%)
Nep7	NP_651603.1	PepO	60..717	CDD:226118	164/722 (23%)
Nep7	NP_651603.1	M13	66..715	CDD:189000	162/716 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850