DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and Nep5

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	812	Identity:	197/812 - (24%)
Similarity:	333/812 - (41%)	Gaps:	162/812 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGLLLGAILFSICAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYACA 66
            ||.||..::..:.||   :...|....|..|.|    |..||.: .|..||:...|.:||.:.|.
  Fly   102 LGGLLALVIILLIAI---IVISLGLKKSSSICRSKECLRTAASL-IYAMDEQTDPCEDFYQFTCG 162

  Fly    67 NWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSCR----LQTND 127
            .|...||...|.|..::..|.|...:|...:.|:|....:|..|..:.|..|.:|.    |...|
  Fly   163 RWANEHPRPDSVTSNDWFRERQAHIMRVVREFLRSNITKSEPEAVGKAKTMYRACMDTKLLDKRD 227

  Fly   128 TRSALNTLQNVTDFRGGWP------EIRVASWYQY-------EYDWLQVVANLKRKLGVDIFIGL 179
            ....:|.|     .|.|.|      .:.:.|..:|       :|:|||.:.::|:.|.:|:.||.
  Fly   228 LEPLINYL-----LRFGLPVLPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGF 287

  Fly   180 EVILDYKEEKMHRLKIGAPQ----FP--------MSRRHYLHPHF----------EGTREI---- 218
            :|..|.....::|:.:|.|:    ||        |.|:.:....|          |..||.
  Fly   288 DVFPDPFNRTINRIALGTPETDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEE 352

  Fly   219 --------------YERSIENKLKLYF-----PEQSEHWRQEVASQVVQIEQQL------AKGL- 257
                          |.|.:..|..||.     .|::.....|:..|.|::.:::      |:.:
  Fly   353 AAKQTSTGMTAYLHYVRKVIEKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMT 417

  Fly   258 --PHNPALTLAQTTRQ--RTAAEMKTAYGSYVDVTRYLQLI-----------FNDNLYMDLYETP 307
              ..|||..:...|.|  :...:...|..:.....||::||           ...||.:...:..
  Fly   418 KPSKNPADDIVYITLQDLQNQTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQAD 482

  Fly   308 EDYMSNLVDVIRETPKLQLANYTMWKALEALDIARVPASQR---ADIWCVQLAQQ-------FFP 362
            ..|:.|:|:.:.:||...:.:|.....:|.| :....:|.|   ::...|.:..:       :..
  Fly   483 ITYLQNIVEYLDDTPASHIESYLFLSTIEEL-VLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCA 546

  Fly   363 HQLESLFHRNYNHM--------QMINELQSTWSDIKRVFREDLQASERLL----WLTLETRQKAI 415
            :.:.||.....:::        :.:.:::...|||:|.|       :||:    |:...|::|.|
  Fly   547 NGVNSLLGMAVSYVLADADFTKEKLPKVERMLSDIRRSF-------DRLVKSTSWMDAATKRKTI 604

  Fly   416 TKLEALK--LHFRTHDDNKLIRQMH--GLILNMDRFYPNLVSVLQWKTQRGLAKL-MTEPV--AE 473
            .|...:|  :.|.....|..:...:  |..:|......||:..:.|:....|.:: ..||:  |.
  Fly   605 QKSAEMKSFIGFPPWLRNASVLNAYYEGAEVNASTHLENLMDFVHWQMMDKLNEMDKPEPIGWAT 669

  Fly   474 DEVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLK---YATLGVLLARQMLHGFDGVGRRYD 535
            ...:....:..|.|.|.|||..||.     |.|..||:   |.::|.:|..::.||||..|||:|
  Fly   670 SPSNVNAFHTFQSNAITVPIAILQY-----PFYDLGLEALNYGSIGTILGHELTHGFDDSGRRFD 729

  Fly   536 AYGYKNNWWDHTSESSYSRRTQCFQEQY-----AIFVEYKGKPVQDKDLLRRIVADNGALDIAYR 595
            ..|....||.:.:...|..||:||.|||     |...||    :..:..|...:||||.:..|:.
  Fly   730 RAGNMVEWWSNRTIDEYVNRTECFVEQYSRYHLADIDEY----IDGELTLGENIADNGGMREAFY 790

  Fly   596 AYQQWLKNAAETPVIYQRERLPLLDH-DHNQIFYLGYAQLYCTDYPETVERF----DELPEQLRV 655
            ||:.::|....     :|.:||.|:| .|.|:|::.:..|:|..|.....|:    ...|.|:|:
  Fly   791 AYRLYVKEVGR-----ERSKLPGLEHYSHEQLFFISFGNLWCETYTPAASRYALTDSHCPGQMRL 850

  Fly   656 NTALSNSQQFANAYGCSREEKLNA-RFKCTLY 686
            ...||||::||..:.|:|...:|. :.||.::
  Fly   851 RGVLSNSEEFARTFKCARGTPMNPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	180/753 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	178/745 (24%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	183/762 (24%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	180/755 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920