Protein Alignment Nepl15 and phex

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001307259.2
• Gene: phex / 386969
• ZFINID: ZDB-GENE-030103-2
• Length: 745
• Species: Danio rerio
• Alignment Length: 758
• Identity: 186/758 - (24%)
• Similarity: 320/758 - (42%)
• Gaps: 139/758 - (18%)

  Fly     6 LGLLLGAILFSICAIDASV---PHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNYACAN 67
            :.||:..|..|..|.:..:   ||.:.|..||    |:|.        |:....|::||.|||..
Zfish    33 IALLIAVITVSQKASNEDLCLGPHCVEAAGSI----LSKM--------DQSVDPCDDFYQYACGG 85

  Fly    68 WPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSC----RLQTNDT 128
            |.|.:|..:..:.......|::....|..::|:...|..:..|.::.|..|.||    .|:..|.
Zfish    86 WLRENPIPEDSSSYGIYPWLRQNVDLKLKELLEQPVRSGDIEAVKKAKVLYASCMNESALEIEDA 150

  Fly   129 RSALNTLQNVTDFRGGWPEIRVA-----SWYQYEYDWLQVVANLKRKLGVDIFIGLEVILDYKEE 188
            ...|..|:. .:||  ||.:..|     .|.:.:::.|:.:|.::.:....:.|.|.|..|.|..
Zfish   151 NPLLKNLKQ-KEFR--WPVLGDALGSSSRWVESQFNLLETLAQIRSQHSKSVLIRLFVAPDDKNS 212

  Fly   189 KMHRLKIGAPQFPM-SRRHYLHPHFEGTREIYERSIENKLKLYFPEQ-----SEHWRQEVASQVV 247
            ..:.:|:......: ||..|:....|.  ::|..::   |:|.....     ||...:.....|:
Zfish   213 NQYIIKLDQASLSLSSREDYITNTTEA--QMYREAL---LRLMVDVSVMLGASEQAAEAQMKSVL 272

  Fly   248 QIEQQLAK-GLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTR---------YLQLIFNDNLYMD 302
            ..|.:||: .:|:          ..||:..|...| |...:.|         :::.:.:..||.|
Zfish   273 DFEMKLAQIVIPY----------ENRTSENMYNKY-SLSKLQRTVPDFNWLGFVRAVIDTELYPD 326

  Fly   303 L---------YETPEDYMSNLVDVIRETPKLQLANYTMWKAL-------------EALDIARVP- 344
            |         ...|: |..:|..:|..|....:|||.:|:::             ..||.|||.
Zfish   327 LKISSSEQVIVRAPQ-YFKDLFKLINATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDFARVTT 390

  Fly   345 -ASQRADIW--CVQLAQQFFPHQ-----LESLFHRNYNHM--QMINELQSTWSDIKRVFREDLQA 399
             .:.....|  ||...:....:.     ::..|..:..||  ::||.::..:.||.....|
Zfish   391 GTTSLTPRWDKCVNYVENTLIYAAGRLFVDKHFQEDKKHMMEELINGIRWAFIDILEKENE---- 451

  Fly   400 SERLLWLTLETRQKAITKLEAL--KLHFRTH--DDNKLIRQMHGLILNMDRFYPNLVSVLQWKTQ 460
                 |:..||::|||.|..|:  |:.:...  :|..:...:..|...|..::.|::..|::..|
Zfish   452 -----WMDEETKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMTDYFGNVMQTLKFIAQ 511

  Fly   461 RGLAKL---------MTEPVAEDEVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLG 516
            ..:..|         .|.|...:     ..|....|:|:.|...||..|||...||..|.|..:|
Zfish   512 SDIGWLRKTVPRTEWFTNPTTVN-----AFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIG 571

  Fly   517 VLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQY-AIFVEYKGKPVQDKDLL 580
            |::..::.||||..||:||..|..:.||.::|.:.::.:|||..:|| :.:.:..|..|:.|..|
Zfish   572 VIVGHELTHGFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTL 636

  Fly   581 RRIVADNGALDIAYRAYQQWL---KNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE 641
            ...:||||.:..::|||::|:   :...|.|:      ||.:...|||:|:|.||.:.|..| ||
Zfish   637 AENIADNGGIRESFRAYRRWVEKERGGVEEPL------LPGVGLTHNQLFFLSYAHVRCNAYRPE 695

  Fly   642 TVERFDEL------PEQLRVNTALSNSQQFANAYGCSREEKLN 678
            ...  |::      |.:.||..|:||.::|..|:.|.....:|
Zfish   696 AAR--DQIQSGAHSPPKYRVIGAMSNFEEFRKAFNCPETSIMN 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	173/705 (25%)
phex	NP_001307259.2	None