DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and Kel

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001178540.1	Gene:	Kel / 297025	RGDID:	1565470	Length:	713	Species:	Rattus norvegicus

Alignment Length:	778	Identity:	156/778 - (20%)
Similarity:	271/778 - (34%)	Gaps:	199/778 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GLLLGAILFSICAIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNYACANWPRL 71
            |||:|..:..:.......|....:...::::.     |..| .|:.....|.:|:::||
  Rat    37 GLLIGCSMLWVYIFRNCGPWTCESPVCMELVN-----HYLA-SGNRSAAPCTDFFSFAC------ 89

  Fly    72 HPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTNDTRSALNTLQ 136
               .|:...:|..:.|.|....:...:|::.......|.:.:...||.||........|....|.
  Rat    90 ---EKANGTSNSFQALAEENKSRLWKLLEAPGSWHLESGEEKAFQFYNSCMDTDAIEASGTGPLV 151

  Fly   137 NVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFP 201
            .:....|||   .::..:.: :|:.|.:..|..:.|                          .||
  Rat   152 QIIKELGGW---NISGNWTF-FDFNQNLRLLMSQYG--------------------------HFP 186

  Fly   202 MSRRHYLHPH---------------------FEGTREIYERSIE------NKLKLYFPEQSEHWR 239
            ..|. |||||                     .:..:::|.:.:.      |:|........:..:
  Rat   187 FFRA-YLHPHPAPPHTPIIQIDQPEFDILLQQDQEQKVYAQILREYVTYLNRLGTLLGSNPQEAQ 250

  Fly   240 QEVASQVV-----------QIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQL 293
            |..:..:|           |.:||....|.|...:...|        ||..|    :|....||.
  Rat   251 QHASWSIVFTSRLFQFLRPQQQQQAQDKLFHVVTIDALQ--------EMAPA----IDWLSCLQA 303

  Fly   294 IFNDNLYMDLYETPE--------DYMSNLVDVIRE-------------------------TPKLQ 325
            ||..   |.|  :|.        ||:.|:..::.|                         ..|.|
  Rat   304 IFTP---MSL--SPSQTLQVHDLDYLRNMSQLVEEGLLNHSEIIQSYMILGLVDTLSPALATKFQ 363

  Fly   326 LANYTMWKALEAL-DIARVPASQRADIW--CVQLAQQFFPHQLESLF-HRNYN------HMQMIN 380
            .|...:.:.|..| :...:||..|   |  ||:....||...|.:|| |..:.      .|::..
  Rat   364 EARRELTQKLRKLKERPPLPAYPR---WMKCVEQTGSFFEPTLAALFVHEAFGPSIRSAAMELFA 425

  Fly   381 ELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEALKLHF---RTHDDNKLIRQMHGLIL 442
            |::.  :.|.|:        ::|.|::.|||::|:.||..|::..   :.....::.:|.:..|.
  Rat   426 EIKD--AVIVRL--------KKLSWISEETRKEALNKLTQLQVEMGAPKRALKTEMAKQEYSDIQ 480

  Fly   443 NMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFW 502
            ....|..:.:|.:: ..|....:...:|.......|.|     :|.:..:.:..|...||..||
  Rat   481 LGPSFLQSFLSCVR-SLQGRKVRSFLQPFPYHRWQKSPWSVSAYYSVPDHVVVFPAGLLQPPFF- 543

  Fly   503 DPAYPNGLKYATLGVLLARQMLHGF-----DGVGRRYDAYGYKNNWWDHTSESSYSRRTQ----C 558
            .|.||..:.:..:|.::|.::||.|     .|.....|                 :|..|    |
  Rat   544 HPGYPRAVNFGAVGSIMAHKLLHIFFQFLLPGGCPACD-----------------TRALQEALLC 591

  Fly   559 FQEQYAIFVEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDH 623
            .:.:||.|.............|....||.|.:.||::||::.:........:..:|..|.
  Rat   592 LEHRYAAFPLPSMSSFNGSHTLLENAADIGGVAIAFQAYRKRITERTGELTLPNQELSPY----- 651

  Fly   624 NQIFYLGYAQLYCTDYPETVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
             |:|:..|||:.|.:......:....|.:|||:..||||..||..:.|.....||...:|.|:
  Rat   652 -QLFFRSYAQVMCRELISQDPQDTHSPPRLRVHGPLSNSPDFAKHFLCPSGSLLNPSTRCKLW 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	146/724 (20%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	144/717 (20%)
Kel	NP_001178540.1	PepO	75..713	CDD:226118	147/732 (20%)
Kel	NP_001178540.1	M13	78..711	CDD:189000	146/727 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.810