Protein Alignment Nepl15 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 794
• Identity: 197/794 - (24%)
• Similarity: 335/794 - (42%)
• Gaps: 169/794 - (21%)

  Fly     8 LLLGAIL-----FSI-----------------------CAIDASVPHPLAANYSIDILRLAKAAH 44
            ||||||:     :||                       ...|:|:...:....|..|    .||.
Mouse    27 LLLGAIVTLGVFYSIGKQLPLLTSLLHFSWDERTVVKRALRDSSLKSDICTTPSCVI----AAAR 87

  Fly    45 IKAYMGDEKEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGA-EN 108
            |...| |:....|.|||.|||..|.|.|...::.:|.:..:.|:        |.|:...:|. |:
Mouse    88 ILENM-DQSRNPCENFYQYACGGWLRHHVIPETNSRYSVFDILR--------DELEVILKGVLED 143

  Fly   109 S------ADRQLKYFYGSCR----LQTNDTRSALNTLQNVTDFRGGWPEIRVASW-----YQYEY 158
            |      |..:.|..|.||.    ::..|:...|:.|:.|    |||| :.:..|     .::|.
Mouse   144 STSQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLSVLKMV----GGWP-VAMDKWNETMGLKWEL 203

  Fly   159 DWLQVVAN--LKRKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFE-----GTR 216
            :....|.|  ..|::.:|:||.    .|.:....|.:.|..|...|..|.|   :|:     ..|
Mouse   204 ERQLAVLNSQFNRRVLIDLFIW----NDDQNSSRHVIYIDQPTLGMPSREY---YFQEDNNHKVR 261

  Fly   217 EIY---ERSIENKLK--LYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAA- 275
            :.|   ..|:...|:  ....::|...|:|:| :|:::|..||..       |:.|..|....|
Mouse   262 KAYLEFMTSVATMLRKDQNLSKESAMVREEMA-EVLELETHLANA-------TVPQEKRHDVTAL 318

  Fly   276 -------EMKTAYG-SYVDVTRYLQLIFND---NLYMD----LYETPEDYMSNLVDVIRETPKLQ 325
                   |::..:| ...:.|.::|.:.:.   .|:.|    :|..|  |:.||.|:|.......
Mouse   319 YHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVYGIP--YLENLEDIIDSYSART 381

  Fly   326 LANYTMWKALEALDIARVPA-SQRADIWCVQLAQQFFPHQLESLFHR---NYNHMQMINELQSTW 386
            :.||.:|:    |.:.|:.: |||.....|...:..:...:|.:..|   :|.:..|.:.:.|.:
Mouse   382 MQNYLVWR----LVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECVSYVNSNMESAVGSLY 442

  Fly   387 SDIKRVFREDLQASER----------------LLWLTLETRQKAITKLEALKLH-------FRTH 428
              |||.|.:|.:::.|                |.|:..|:::||..|  |:.:.       :...
Mouse   443 --IKRAFSKDSKSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEK--AMNIREQIGYPDYILE 503

  Fly   429 DDNK-LIRQMHGLILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAED-------EVHKLPHYEIQ 485
            |:|| |..:...|....|.::.|.:..|:...||.|.|| .|.|.::       .|:..  |...
Mouse   504 DNNKHLDEEYSSLTFYEDLYFENGLQNLKNNAQRSLKKL-REKVDQNLWIIGAAVVNAF--YSPN 565

  Fly   486 KNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSES 550
            :|:|..|...||..|| ....|..|.:..:|:::..::.||||..||.:|..|...:||.:.|..
Mouse   566 RNQIVFPAGILQPPFF-SKDQPQSLNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSAR 629

  Fly   551 SYSRRTQCFQEQYAIFVEYK---GKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQ 612
            .:.:::||...||..| .::   .:.|.....|...:||||.:..||:||.:||.:..:.
Mouse   630 HFQQQSQCMIYQYGNF-SWELADNQNVNGFSTLGENIADNGGVRQAYKAYLRWLADGGKD----- 688

  Fly   613 RERLPLLDHDHNQIFYLGYAQLYCTDY-PE----TVERFDELPEQLRVNTALSNSQQFANAYGCS 672
             :|||.|:..:.|:|::.|||::|..| ||    :::.....|.:.||..:|.|...|:.|:.|.
Mouse   689 -QRLPGLNLTYAQLFFINYAQVWCGSYRPEFAVQSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCP 752

  Fly   673 REEKLNARFKCTLY 686
            |...::...:|.::
Mouse   753 RGSPMHPMKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	179/714 (25%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	179/715 (25%)