DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and Phex

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_037136.2	Gene:	Phex / 25512	RGDID:	3323	Length:	749	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	182/765 - (23%)
Similarity:	318/765 - (41%)	Gaps:	149/765 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLGAILFSI-------------C----AIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQ 55
            |:||.:||.:             |    .|:|:.......|.|:|
  Rat    31 LVLGTLLFLVSQGLLSFQAKQEYCLKPECIEAAAAIMSKVNLSVD-------------------- 75

  Fly    56 ACNNFYNYACANWPRLHPARKSKTRTNYLEELQ-ELYIRKSADMLKSATRGAENSADRQLKYFYG 119
            .|.||:.:||..|...:|..:..........|: .:.::..|.:.||.:|..:..|.::.|..|.
  Rat    76 PCENFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVSRRRDTEAVQKAKILYS 140

  Fly   120 SC----RLQTNDTRSALNTLQNVTDFRGGWPEIRV-----ASWYQYEYDWLQVVANLKRKLGVDI 175
            ||    .::..|.:..|:.|:: :.||  ||.:..     ..|.:.::..||.:|..:.:....:
  Rat   141 SCMNEKAIEKADAKPLLHILRH-SPFR--WPVLEANIGPEGVWSERKFSLLQTLATFRGQYSNSV 202

  Fly   176 FIGLEVILDYKEEKMHRLKIGAPQFPMS-RRHYLHPHFEGTRE-------IYERSIENKLKL-YF 231
            ||.|.|..|.|....|.||:......:: |..:|    :.|.|       :|:..::..:.| ..
  Rat   203 FIRLYVSPDDKASNEHILKLDQATLSLAVREDFL----DNTTEAKSYRDALYKFMVDTAVLLGAN 263

  Fly   232 PEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQLIFN 296
            ..::||..:.|....::|.:.:   :||....:.|...:. ..:|:......: |...|::.:.:
  Rat   264 SSRAEHDMKSVLRLEIKIAEIM---IPHENRTSEAMYNKM-NISELSAMIPQF-DWLGYIKKVID 323

  Fly   297 DNLYMDLYE----------TPEDYMSNLVDVIRETPKLQLANYTMWKALEALDIARVP-ASQRAD 350
            ..||..|.:          .|: |..:|..::....|..:|||.:|:.:    .:|:| .|:|..
  Rat   324 TRLYPHLKDIGPSENVVVRVPQ-YFKDLFRILGAERKKTIANYLVWRMV----YSRIPNLSRRFQ 383

  Fly   351 I------------------W--CVQLAQQFFPHQLESLF---HRNYNHMQMINELQS--TWSDIK 390
            .                  |  ||...:...|:.:..:|   |...:..:|:.||..  .|:.|.
  Rat   384 YRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVNVHFQEDKKEMMEELIEGVRWAFID 448

  Fly   391 RVFREDLQASERLLWLTLETRQKAITKLEAL--KLHFRTH--DDNKLIRQMHGLILNMDRFYPNL 451
            .:.:|:       .|:...|::||..|..|:  |:.:...  :|..:...:..:..:...::.|
  Rat   449 MLEKEN-------EWMDAGTKRKAQEKARAVLAKVGYPEFIMNDTYVNEDLKAIKFSESDYFGN- 505

  Fly   452 VSVLQWKTQRGLAK----LMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFWDPAYP 507
              |||  |::.||:    .:.:.|.:.|....|     .|....|:|:.|...||..|||...||
  Rat   506 --VLQ--TRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYP 566

  Fly   508 NGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYK-G 571
            ..|.|..:||::..:..||||..||:||..|..:.||...||..:..:|:|...||:.:...| |
  Rat   567 RSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSVDSEEKFKEKTKCMINQYSNYYWKKAG 631

  Fly   572 KPVQDKDLLRRIVADNGALDIAYRAYQQWL---KNAAETPVIYQRERLPLLDHDHNQIFYLGYAQ 633
            ..|:.|..|...:||||.|..|:|||::|:   :...|.|:      ||.:...:||:|:|.||.
  Rat   632 LNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGVEEPL------LPGITFTNNQLFFLSYAH 690

  Fly   634 LYCTDY-PETVERFDEL----PEQLRVNTALSNSQQFANAYGCSREEKLN 678
            :.|..| ||......::    |.|.|||.|:||.::|..|:.|.....:|
  Rat   691 VRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPANSTMN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	171/699 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	170/696 (24%)
Phex	NP_037136.2	M13	74..740	CDD:341056	171/720 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920