DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and Mme

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_036740.1	Gene:	Mme / 24590	RGDID:	3098	Length:	750	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	190/760 - (25%)
Similarity:	318/760 - (41%)	Gaps:	113/760 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLGLLLGAILFSICAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYAC 65
            ||.:.| ::|..:..|.|.....|.|.|...|.:    :..||.:...| |...:.|.:|:.|||
  Rat    26 PLEISL-SVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNM-DASAEPCTDFFKYAC 88

  Fly    66 ANWPRLHPARKSKTRTNYLEELQ-ELYIRKSADMLKSATRGAENS---ADRQLKYFYGSCRLQTN 126
            ..|.:.:...::.:|.:..:.|: ||.:     :||...:..:..   |.::.|..|.||..::.
  Rat    89 GGWLKRNVIPETSSRYSNFDILRDELEV-----ILKDVLQEPKTEDIVAVQKAKTLYRSCINESA 148

  Fly   127 -DTRSALNTLQNVTDFRGGWPEIRVAS--WYQ-YEYDWL--QVVANLKRKLGVDIFIGLEVILDY 185
             |:|.....|..:.|.. |||   |||  |.| |...|.  :.:|.|..|.|..:.|...|..|.
  Rat   149 IDSRGGQPLLTLLPDIY-GWP---VASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDD 209

  Fly   186 KEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREIYERSI-----------------------ENKL 227
            |....|.:....|:..:..|.|    :|.| .||:.:.                       ||:|
  Rat   210 KNSTQHIIHFDQPRLGLPSRDY----YECT-GIYKEACTAYVDFMISVARLIRQEQRLPIDENQL 269

  Fly   228 KLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQ 292
            .|...:..| ..:|:|:...:.|.:....|.:| .:|||: .:...:.|:.....|:.:.|..:.
  Rat   270 SLEMNKVME-LEKEIANATTKPEDRNDPMLLYN-KMTLAK-LQNNFSLEINGKPFSWSNFTNEIM 331

  Fly   293 LIFNDNLYMD---LYETPEDYMSNLVDVIRETPKLQLANYTMWKAL---------------EALD 339
            ...|.|:..:   :...|| |::.|..::.:.....|.|...|:.:               .|..
  Rat   332 STVNINIQNEEEVVVYAPE-YLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFR 395

  Fly   340 IARVPASQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSD----IKRVFREDLQAS 400
            .|....:.....|  :....:....:|:...|.|.......|.:....|    |:.||   :|..
  Rat   396 KALYGTTSETATW--RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVF---IQTL 455

  Fly   401 ERLLWLTLETRQKAITKLEALKLHFRTHDD-----NKLIRQMHGLILNMDRFYPNLVSVLQWKTQ 460
            :.|.|:..||::||..|..|:|......||     |||..:...|....:.::.|::..|::...
  Rat   456 DDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQS 520

  Fly   461 RGLAKLMTEPVAEDE-------VHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVL 518
            :.|.|| .|.|.:||       |:..  |...:|:|..|...||..|| .....|.|.|..:|::
  Rat   521 KQLKKL-REKVDKDEWISGAAVVNAF--YSSGRNQIVFPAGILQPPFF-SARQSNSLNYGGIGMV 581

  Fly   519 LARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV--EYKGKPVQDKDLLR 581
            :..::.||||..||.::..|...:||...|.:::..::||...||..|.  ...|:.:...:.|.
  Rat   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLG 646

  Fly   582 RIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE---- 641
            ..:||||.:..||||||.::|...|      .:.||.||.:|.|:|:|.:||::|..| ||
  Rat   647 ENIADNGGIGQAYRAYQNYVKKNGE------EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705

  Fly   642 TVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :::.....|...|:...|.||.:||:|:.|.:...:|...||.::
  Rat   706 SIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	175/700 (25%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	173/693 (25%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_036740.1	M13	79..748	CDD:341056	175/701 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950