Protein Alignment Nepl15 and Mme

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_036740.1
• Gene: Mme / 24590
• RGDID: 3098
• Length: 750
• Species: Rattus norvegicus
• Alignment Length: 760
• Identity: 190/760 - (25%)
• Similarity: 318/760 - (41%)
• Gaps: 113/760 - (14%)

  Fly     5 PLGLLLGAILFSICAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYAC 65
            ||.:.| ::|..:..|.|.....|.|.|...|.:    :..||.:...| |...:.|.:|:.|||
  Rat    26 PLEISL-SVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNM-DASAEPCTDFFKYAC 88

  Fly    66 ANWPRLHPARKSKTRTNYLEELQ-ELYIRKSADMLKSATRGAENS---ADRQLKYFYGSCRLQTN 126
            ..|.:.:...::.:|.:..:.|: ||.:     :||...:..:..   |.::.|..|.||..::.
  Rat    89 GGWLKRNVIPETSSRYSNFDILRDELEV-----ILKDVLQEPKTEDIVAVQKAKTLYRSCINESA 148

  Fly   127 -DTRSALNTLQNVTDFRGGWPEIRVAS--WYQ-YEYDWL--QVVANLKRKLGVDIFIGLEVILDY 185
             |:|.....|..:.|.. |||   |||  |.| |...|.  :.:|.|..|.|..:.|...|..|.
  Rat   149 IDSRGGQPLLTLLPDIY-GWP---VASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDD 209

  Fly   186 KEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREIYERSI-----------------------ENKL 227
            |....|.:....|:..:..|.|    :|.| .||:.:.                       ||:|
  Rat   210 KNSTQHIIHFDQPRLGLPSRDY----YECT-GIYKEACTAYVDFMISVARLIRQEQRLPIDENQL 269

  Fly   228 KLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQ 292
            .|...:..| ..:|:|:...:.|.:....|.:| .:|||: .:...:.|:.....|:.:.|..:.
  Rat   270 SLEMNKVME-LEKEIANATTKPEDRNDPMLLYN-KMTLAK-LQNNFSLEINGKPFSWSNFTNEIM 331

  Fly   293 LIFNDNLYMD---LYETPEDYMSNLVDVIRETPKLQLANYTMWKAL---------------EALD 339
            ...|.|:..:   :...|| |::.|..::.:.....|.|...|:.:               .|..
  Rat   332 STVNINIQNEEEVVVYAPE-YLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFR 395

  Fly   340 IARVPASQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSD----IKRVFREDLQAS 400
            .|....:.....|  :....:....:|:...|.|.......|.:....|    |:.||   :|..
  Rat   396 KALYGTTSETATW--RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVF---IQTL 455

  Fly   401 ERLLWLTLETRQKAITKLEALKLHFRTHDD-----NKLIRQMHGLILNMDRFYPNLVSVLQWKTQ 460
            :.|.|:..||::||..|..|:|......||     |||..:...|....:.::.|::..|::...
  Rat   456 DDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQS 520

  Fly   461 RGLAKLMTEPVAEDE-------VHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVL 518
            :.|.|| .|.|.:||       |:..  |...:|:|..|...||..|| .....|.|.|..:|::
  Rat   521 KQLKKL-REKVDKDEWISGAAVVNAF--YSSGRNQIVFPAGILQPPFF-SARQSNSLNYGGIGMV 581

  Fly   519 LARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV--EYKGKPVQDKDLLR 581
            :..::.||||..||.::..|...:||...|.:::..::||...||..|.  ...|:.:...:.|.
  Rat   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLG 646

  Fly   582 RIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE---- 641
            ..:||||.:..||||||.::|...|      .:.||.||.:|.|:|:|.:||::|..| ||
  Rat   647 ENIADNGGIGQAYRAYQNYVKKNGE------EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705

  Fly   642 TVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :::.....|...|:...|.||.:||:|:.|.:...:|...||.::
  Rat   706 SIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	175/701 (25%)
Mme	NP_036740.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:341056	175/701 (25%)