DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-2

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_494343.2	Gene:	nep-2 / 188090	WormBaseID:	WBGene00020230	Length:	736	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	181/767 - (23%)
Similarity:	305/767 - (39%)	Gaps:	152/767 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLGAILFSICAIDASVPHPLAANY--SIDIL---RLAKAAHIKAYMGDEKEQACNNFYNYACAN 67
            |:|||.::            ...||  |.|:.   ...|.|.:.....:.....|::||.:||..
Worm    34 LVLGAAIY------------FYINYKDSSDVCLSPGCIKTASVILSSMNSSVDPCDDFYEFACGQ 86

  Fly    68 WPRLHPARKSKTRTNYLEEL---QELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTNDTR 129
            |.:.||........:..|.|   .|..:::..|. .......|.||..:.||||..|..::....
Worm    87 WIKGHPIPDDAPSVSNFENLGQDLEFALKELLDE-NDEPYDYETSAVGKAKYFYNLCLNESEILD 150

  Fly   130 SALNTLQNVTDFRGGWPEIRVASWYQYEYDWL--QVVANLKRKLGVDIFIGLEVILDYKEEKMHR 192
            :...|...|....||||.:    .:|.:.|..  .:.|::..|...|......|..|.|..:.|.
Worm   151 NWRTTFDEVVKSFGGWPSL----GHQMKPDASIEMLYADMVAKFKADSLFKATVQPDDKNSQRHV 211

  Fly   193 LKIGAPQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPEQSEHWRQEV-ASQVVQIEQQLAKG 256
            |.|..||..:..|.:........|..|.:.|.:.|.|.   .::..|..: |.:::..|..||.
Worm   212 LLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILL---DADRTRATLDAKEIIDFETALAN- 272

  Fly   257 LPHNPALTLAQTTR--------QRTAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYE------TP 307
                  :|:|...|        :.|..||:.:      :..:...:|.:.::.||:|      |.
Worm   273 ------ITMADEHRHDIAELYTKITLGEMRRS------LPHFNWPLFFNRMFKDLHEKNGKRITF 325

  Fly   308 ED----------YMSNLVDVIRETPKLQLANYTMW-----------------------KALEALD 339
            :|          ::..|..:|.:.....:.||..|                       |.|..::
Worm   326 DDNTEVVVYGYEFLRRLDVLIPQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTIFKFYKTLNIMN 390

  Fly   340 IARVPASQRADIW--CVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQASER 402
            :.:|.       |  ||.......|....:::.:|:...:...:::...|.|...| .||..||.
Worm   391 VQKVR-------WHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVEEMISLIMESF-VDLLLSED 447

  Fly   403 LLWLTLETRQKAITKLEALKLHF----------RTHDDNKLIRQMHGLILNMDRFYPNLVSVLQW 457
              |||.||:|.|..|:..:|...          ..:::.|..:...|      .:|....|..:
Worm   448 --WLTKETKQTAKQKVNEMKRKIGYPDYLNDPAAVNNEYKTFKVYPG------HYYQTKFSFYE- 503

  Fly   458 KTQRGLAKLMTEPVAEDE-------VHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATL 515
            :.||.:.:.:||.|..:.       |:..  |....|.|..|...||. .|:...:|:.:.:..:
Worm   504 QYQRDVLERITEAVDRERWVAGAALVNAF--YSPNTNEIIFPAGILQP-VFYSKDFPSSMNFGGI 565

  Fly   516 GVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV------EYKGKPV 574
            ||::..::.||||..||.||..|....|||:.:.|.:..:.||.::||:.:|      :..||..
Worm   566 GVVIGHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKST 630

  Fly   575 QDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYC--T 637
            :.::     :||||.|..|||||:::.|..:..|      |||.::..|:|:|:|.|||::|  .
Worm   631 KGEN-----IADNGGLKQAYRAYKKYEKRHSRPP------RLPGVNLTHDQLFFLNYAQIWCGTM 684

  Fly   638 DYPETVERF---DELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :..|.:.:.   :..|..:||...||||..||.||.|....::|.|.||.::
Worm   685 NDKEAIRKLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	170/709 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	167/702 (24%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	172/726 (24%)
nep-2	NP_494343.2	M13	73..734	CDD:189000	170/712 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920