DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-18

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_494297.1	Gene:	nep-18 / 186911	WormBaseID:	WBGene00019343	Length:	701	Species:	Caenorhabditis elegans

Alignment Length:	733	Identity:	158/733 - (21%)
Similarity:	277/733 - (37%)	Gaps:	157/733 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 AHIKAYMGDEKEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAE 107
            |.||.|. :.....|.:|:.:.|..:.. |.  .......|::..|.||   ....:...|....
Worm    37 AMIKNYQ-NASVDPCEDFFEHTCGRYSE-HV--MDDNSWGYVQYKQLLY---QVFAIARKTNKFN 94

  Fly   108 NSADRQLKYFYGSCRLQTNDTRSALNTLQNVTDFRGGWPEIRVASWYQYEYD-------WLQVVA 165
            :..:.||:.|..||..:..........|:|..:.|||:|.|. .:|.:.::|       :|.:..
Worm    95 SKPNEQLRIFTKSCLDRKEMDEDTFQDLRNDIEERGGFPMID-PNWNEEKFDLSDMLAKYLSINR 158

  Fly   166 NLKRKLGVDIFIGLEVILDYKEEKMHRLKIG-APQFPMSRRHYLHPHFEGTREIYERSI----EN 225
            |....|.|:.:..:|     ..:.::||.:. .|       |:::....|. .||:.|:    ..
Worm   159 NRMGFLSVEPYAAIE-----GNKSVNRLYVSPGP-------HWVYNWAMGI-SIYKDSVAFMLRR 210

  Fly   226 KLKLYFPEQSEHWRQEVASQVVQIE-------------------------QQLAKGLPHNPALTL 265
            .|||...|.:|....:..:::||:|                         ..|.|.:|....:.:
Worm   211 LLKLENRELNETIYDKEFAELVQLEANFSTLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKI 275

  Fly   266 AQT-TRQRTAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYETPEDYMSNLVDVIRETPKLQLANY 329
            .:. .|..|:.|.:......|.|....:..|.:|             ..|..:..||||..||||
Worm   276 LKALARHGTSEEDEEKLLERVTVHGAGEYFFGEN-------------RELARIATETPKSALANY 327

  Fly   330 TMWKALEALDIARV------PASQR------ADIWCVQLAQQFFPHQLESLFHRN----YNHMQM 378
            .:.:.|  :|:|..      |...:      ...:|......|||....::|..:    ..::::
Worm   328 LVVRQL--IDVALYFYDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFKIENLKV 390

  Fly   379 INELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEAL--KLHFRTHDDNK-LIRQMHGL 440
            |.|:   :..||..:.:....:|   :|.||.|:..|.||.|:  |.....:.:.| |:.:|:..
Worm   391 IEEM---FVKIKAEYEQIFTENE---YLELEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMYET 449

  Fly   441 ILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHKLP-----------H--YEIQKNRIQVP 492
            :..:|...|       |:....:.:..:|.:.|..||..|           |  |:...|...:.
Worm   450 LNFLDTDSP-------WQVYMKMWRHWSEQLVEHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYIN 507

  Fly   493 ITFLQARFFW-DPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWW---DHTSESSYS 553
            :.:|  .:.| |..:|....|..||.::..::.|.||...|:.|..|.:..:|   .::|.:.|.
Worm   508 LPYL--TYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYE 570

  Fly   554 RRTQCFQEQYAIFVEYKGKPVQD-----KDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQR 613
            .|.:|.::||:.:.|    |..|     ......|..|:..:..|:|.:::..|.        .|
Worm   571 LREKCLRDQYSAYKE----PGYDFFMNGTHCRYEIAGDHMGIRTAFRVFEKVKKE--------DR 623

  Fly   614 ERLPLLDHDHNQIFYLGYAQLYCTDYPETVERFDELPEQL----------RVNTALSNSQQFANA 668
            .|||.|:....|:|:..||...|..|..     ::||..:          |||..:.|..:||.|
Worm   624 FRLPGLEMSEEQLFFYNYAFRQCDVYNP-----NKLPRNMLARQHPTNRYRVNGVIQNIPEFAEA 683

  Fly   669 YGCSREEKLNARFKCTLY 686
            :.|.:...:|...||.||
Worm   684 FNCPKNSPMNPEMKCKLY 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	151/715 (21%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	149/708 (21%)
nep-18	NP_494297.1	PepO	42..692	CDD:226118	150/717 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:189000	151/718 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880