Protein Alignment Nepl15 and nep-8

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 653
• Identity: 142/653 - (21%)
• Similarity: 276/653 - (42%)
• Gaps: 106/653 - (16%)

  Fly    51 DEKEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLK 115
            |.....|.:|:.::|.   |.|....|::|....:.:....||:....::::|..:||    .:|
 Worm    73 DPSVDPCVDFFQHSCG---RFHEQSVSESRLQKKKHILRKQIREFLHKIQNSTSKSEN----LMK 130

  Fly   116 YFYGSC---RLQTND----TRSALNTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGV 173
            ..:..|   :..:||    :|.|::.:.|.....|.|| :...:|...::|..::::||. |||.
 Worm   131 LVFDKCEASKKTSNDNYKISRDAIHDVFNDIKKIGAWP-LLDKNWDGSKFDLNEMLSNLV-KLGA 193

  Fly   174 DIFIGLEVILDYK---EEKMHRLKIGAPQF--------------PMSRRHYLHPHFEGTREIYER 221
             ..:|| ..||::   |.|..|:   ||..              .:...:.:.|..|...:.:|.
 Worm   194 -TNLGL-FQLDFRILTEGKFVRI---APTLGSIVHNSTMISMISEILEANGVQPDSEEISKEFEE 253

  Fly   222 --SIENKLKLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQ-TTRQRTAAEMKTAYGS 283
              |::.||..|                 |...:|:..||...::..:. .|.....:.:...:|.
 Worm   254 YSSLQMKLAKY-----------------QSSGKLSISLPGVRSINFSSLITEMIHPSRVSKIFGK 301

  Fly   284 YVDVTRYLQLIFNDNLYMDLYETPEDYMSNLVDVIRETPKLQLANYTMWKALE-ALDIARVPASQ 347
            ...||....|.|..|      ||     .:|..:|..|....|||:.::..:: :.:|.:  .::
 Worm   302 IRVVTSEHPLFFKSN------ET-----ESLDTIIESTSNKTLANFLIFNYIQSSYNIMK--GAR 353

  Fly   348 RADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQASERLLWLTLETRQ 412
            |.:  |....::.||.....:|.||:......:.::....::|:...|.:|.:|.   |....::
 Worm   354 RGN--CEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMIQDTEN---LAPPVKE 413

  Fly   413 KAITKLEALK--LHFRTHDD--NKLIRQMHGLIL-NMDRFYPNLVSVLQWKTQRGLAKLMTE-PV 471
            ..:.|:||:|  :.:..|.|  ..|.::.....| :.|.:|.....:.:.::::.:..:..| |:
 Worm   414 SMLKKVEAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKLNRLRSEQQMEFIAGETPI 478

  Fly   472 AE-DEVHKL-PHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRY 534
            :. .||.|: .:|:..||.:.|...||...|| |..||:.:.....|.|:|.::.|..|..|..|
 Worm   479 SPIKEVLKVNANYKRSKNALTVFAPFLDDPFF-DITYPDYVNLFFSGFLIAHEIGHSVDANGLGY 542

  Fly   535 DAYGYKNNW--WDHTSESSYSRRTQCFQEQYAIFVE-YKGKPVQDKDLLRRIVADNGALDIAYRA 596
            |..|...:.  .:|.:|  |.::.||..:||..:.: ..||.:.....:..|:||....::.:||
 Worm   543 DENGKPMDGIRLEHVTE--YGKQGQCLVDQYDNYDDPVYGKKMNGTHSINEIIADWVGHEVTWRA 605

  Fly   597 YQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTD-----YPETVERFDELP-EQLRV 655
            |::     .:|..:.  ..:.|.|.:.:|:::...:.|:|.:     ..||::  |..| :..||
 Worm   606 YKK-----MDTSKML--SLIGLKDINMDQLYFRVQSLLFCRERDTISLEETLK--DVYPTDNFRV 661

  Fly   656 NTA 658
            |.|
 Worm   662 NGA 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	141/648 (22%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	140/648 (22%)