DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-6

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_494537.1	Gene:	nep-6 / 184628	WormBaseID:	WBGene00017550	Length:	726	Species:	Caenorhabditis elegans

Alignment Length:	697	Identity:	155/697 - (22%)
Similarity:	281/697 - (40%)	Gaps:	133/697 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DEKEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSAD--MLKSATRGAENSADRQ 113
            |.....|.:||..||..:.....|.:...:       :::.|::...  :||:.|  :|:.::..
Worm   102 DPSVDPCQDFYKAACGKYSEHEVANRRLQK-------KDIIIQRMIKNFLLKNET--SESKSENV 157

  Fly   114 LKYFYGSCRLQTNDTRSALNTLQNVTDFRGGWPEI-RVASWYQYEYDWLQVVANLKR------KL 171
            ::..|.:|....|:.....|.   .|.||..:.:| ::.||...:.:|.:...||..      ||
Worm   158 MRQVYRTCEGLKNEEIFNANM---KTAFRELFKDIQKIGSWPAADKNWDETKLNLNEMLLNIVKL 219

  Fly   172 GVDIFIGL------EV-ILDYKEEKMHRLKIGAP----QFPMSRRHYLHPHFEGTREIYERSIEN 225
            |...| ||      || .|:...:.....|:.|.    .|.:..::.|.|    ...:....:|:
Worm   220 GSSNF-GLFQIRPTEVPFLEVAPDMARSPKVSANFQQIIFDILEKNGLQP----DENVIADDVED 279

  Fly   226 KLKLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVD---V 287
            .:.|  .|....:..:..::.||..:..|:    .|:|.|.:...:......|....:.|.   |
Worm   280 YITL--EETLSQYAYDYNAEKVQFSKLQAQ----VPSLKLEKIIEEMMNPNRKKLLVTKVKPRMV 338

  Fly   288 TRYLQLIFNDNLYMDLYETPEDYMSNLVDVIRETPKLQLANYTMW----KALEALDIARVPASQR 348
            .....|.|::.:             ||..:::.|||..||||.::    .|:..|.:......:|
Worm   339 AHKHSLFFDEKM-------------NLEKLLKSTPKRTLANYLIFYYMDHAMNGLSVHDNVIKKR 390

  Fly   349 ADIWCVQLAQQFFPHQLESLFHRNY---NHMQMINELQSTWSDIKRVFREDLQASERLLWLTLET 410
            .   |.:|..::.|.....:|.||:   .::::::|:.   .:.|:.|.|.||.|   .||..::
Worm   391 N---CEKLVIEYLPKASLRVFVRNHFEKGNLKIVDEMA---EETKKSFIEMLQES---TWLGADS 446

  Fly   411 RQKAITKLE----------------ALKLHFRTHDDNKLIRQ--MHGLILNMDRFYPNL---VSV 454
            ::.||.|||                ||...|.|   .||:.:  ::|::..:.||:...   ...
Worm   447 KKNAILKLEKMGKMIGYPKEFEKKGALDKMFET---LKLLPKDTLYGILKKIGRFHMEQGIEFVA 508

  Fly   455 LQWKTQRGLAKLMTEPVAEDEVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLL 519
            |:......|..|||.....|           :|.:...:.::....| |..||..:..|..|.:|
Worm   509 LETPMDPVLPVLMTNAFYTD-----------RNHLSFLVGYMDDPLF-DATYPKYVNIALTGNIL 561

  Fly   520 ARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYK----GKPVQDKDLL 580
            |.:..||||..|.:.|..|...:|........|.::|||..:||.   ||.    ||.:.....|
Worm   562 AHETSHGFDTAGIKRDENGEVRSWMKPEDLKEYGKKTQCLVDQYN---EYDDPVFGKNLNGTTTL 623

  Fly   581 RRIVADNGALDIAYRAYQQWLKNAAETPVI-YQRERLPLLDHDHNQIFYLGYAQLYCTDYPETVE 644
            ..:|||...:.:|::.::: |.::.|..|| ::.|.:       :::::...|..:|: .|.|..
Worm   624 NEMVADMIGVTVAWKVFEK-LDSSKEQKVIGFENENI-------DKLYFRAAALDFCS-LPPTTS 679

  Fly   645 RFDELPE-----QLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            ..:||..     ..|||...||..|||.|:.|.....:|.:.:|:::
Worm   680 LVEELTRVHPTGNFRVNGIFSNMPQFATAFNCPEGSPMNPKTRCSIF 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	153/687 (22%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	152/680 (22%)
nep-6	NP_494537.1	M13	105..724	CDD:189000	153/690 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920