DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and nep-22

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_509528.1	Gene:	nep-22 / 181144	WormBaseID:	WBGene00020788	Length:	798	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	155/766 - (20%)
Similarity:	283/766 - (36%)	Gaps:	159/766 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNYACANWPRLHPARK-SKTRTNY 83
            ::.|..:..||||.::.|             |:....|.:||.:.|..:.:....:| .::|...
Worm    62 VNTSPSYTQAANYLLNGL-------------DDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGT 113

  Fly    84 LEELQ-ELYIRKSADMLK-SATRGAENSADRQLKYFYGSCR--LQTNDTRSALNTLQNVTDFRGG 144
            .::.| ::|....|.:.| ..|....:..:|..|..:.:|:  |.:...::|: ....:|...||
Worm   114 YDQAQVDVYSEIVAALSKIDVTSTTTSKTERITKAAFETCKNNLASPADKTAV-VYAEITSLFGG 177

  Fly   145 WPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFPMSRRHYLH 209
            .|..........:| |: |...:::|..|..........|||:...:.|..|.|...::|..|:.
Worm   178 VPFFGEPLKTNVDY-WM-VAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVK 240

  Fly   210 PHFEGTREIYER-SIENKLKLYFPEQSEHWRQEV--------ASQVVQIEQQLA-KGLPHNPALT 264
            |.:  ..|:.:| |..|.|...|...:   ::.|        |.:||..|.|:| ...|.:....
Worm   241 PQY--IAEVNQRVSDVNDLLTAFANAA---KKNVGADALLAAAQEVVNFEVQIAMASWPDDLLRN 300

  Fly   265 LAQTTRQRTAAEMKTAYGSYVDVTRYLQLIFN------DNLYMDLYETPEDYMSNLVDVI--RET 321
            ..|.......|...|||.: ::...||..:|:      |....::..|...|.:.|..|.  :.:
Worm   301 YQQQYNPYNIASATTAYRA-INWKSYLGQLFHGVASDADQANYNIVVTEPSYFAWLNSVFDGKTS 364

  Fly   322 PKLQLANYTMWKAL-EALDIARVPASQR----------------------------ADI-----W 352
            ....:|||.:.:.| :..|... ||:.:                            ||:     .
Worm   365 NSTVVANYMIAQLLADESDFIN-PATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLDGISEG 428

  Fly   353 CVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQAS-ERLLWLTLETRQKAIT 416
            |:.|...:.|:....::.::.:..   |::|:...|...:...:.|.. :.|.|:...::.:|..
Worm   429 CMDLLTAYMPYGTGYVYVKSKSER---NKVQADVKDQTTLIINNFQGMIDSLNWMDTFSKNRAHN 490

  Fly   417 KLEALKLHFRTHDDNKLIRQMHG---LILNMDRFYPNLVSVLQWKTQ------------------ 460
            |.::|..:|...:      .|.|   ....:|.:..:..|::...|:
Worm   491 KSDSLVKNFGWPE------AMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAVLKKGMEV 549

  Fly   461 RGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFWDPA-----YPNGLKYATL 515
            |...::|.||.......:.|     .|:.::|.|..|..      .|:|.     ||....:|..
Worm   550 REFFRIMGEPADRTNFLQSPAMVNAWYQPERNSITFPYA------AWNPPYYNLNYPQAYNFAGQ 608

  Fly   516 GVLLARQMLHGFDGVGRRY-------DAYGYKNNWWDHTSESSYSRRTQCFQEQYA--------- 564
            |.....::.||:|..|.::       |....|..|.|..|.|.:....||...|::
Worm   609 GGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEKTG 673

  Fly   565 -IFVEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLP-LLDHDHNQIF 627
             |... .|...|.::     :||.|....|||:|:|::   |.|....:.:||| |.::..||||
Worm   674 NIHCA-NGATTQGEN-----IADLGGQQAAYRSYRQYV---ATTRKGVEEDRLPGLENYTPNQIF 729

  Fly   628 YLGYAQLYCTDYPET--VERF---DELPEQLRVNTALSNSQQFANAYGCSR 673
            ::.|...:|....:.  |.:.   ...|.|.|.|..:.:..:|...:||.|
Worm   730 WITYGYSWCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVR 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	148/729 (20%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	148/729 (20%)
nep-22	NP_509528.1	PepO	76..795	CDD:226118	150/752 (20%)
nep-22	NP_509528.1	M13	83..793	CDD:189000	148/732 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920