DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-17

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001254395.1	Gene:	nep-17 / 174996	WormBaseID:	WBGene00010070	Length:	1589	Species:	Caenorhabditis elegans

Alignment Length:	744	Identity:	146/744 - (19%)
Similarity:	275/744 - (36%)	Gaps:	161/744 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 CNNFYNYACANWPRLHPARKSKTRTNYLEELQEL-YIRKSADMLKSATRGAENSADRQLKYFYGS 120
            |::||:|||.|:        :::.:.|....|.| |:.:..:.....|....:.|.::.|..|.:
Worm   887 CDDFYSYACGNF--------NQSVSFYTARAQNLVYMAQKLEDPTYQTTINSSPALKKEKQLYNA 943

  Fly   121 CRLQTNDTRSA----------------LNTL--QNVTDFRGGWPEIRVA-------SWYQYEYDW 160
            |...|..::|.                |.||  |:.|...||.|::..|       .:..:|...
Worm   944 CLTATASSQSEDQILISKNYIQTKVDDLKTLIGQDFTLVNGGAPKLPSAKQIGDALGYLSFEQGI 1008

  Fly   161 LQVVANLKRKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFE-GTREIYERSIE 224
            ..:::.|.....:|...|.::.:|.....:.:.......:.:.:..||....: .||...|::|.
Worm  1009 DTLISPLVDTYWIDNSKGYQMFIDQNTAYLSKTYYQPAAWKIEKPKYLKMALDVVTRYAREQNIT 1073

  Fly   225 NKLKLYFPEQSEHWRQEVASQVVQIEQQLA--KGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDV 287
                  .|..:    .::.|.|:..||.:|  .....|......::......:::.|.| :::|.
Worm  1074 ------LPAGA----SDLLSNVLDYEQNIAVKYSTDDNTRRQFQRSWNLTKTSDLVTKY-NFMDW 1127

  Fly   288 TRYLQ--------LIFNDNLYMDLYETPEDYMSNL-VDVIRETPKLQLANYTMWKALEALDIAR- 342
            ..||.        .|.:.|..:.:.|.  |.:::. .|.::::|:| |.|....:.|  |..|:
Worm  1128 MTYLSHAPNAVKAKITDANYQVSVMEV--DRLTHFSADYLQQSPEL-LVNLLFVRLL--LGNAQY 1187

  Fly   343 VPA-----------------SQRADI----------------WCVQLAQQFFPHQLESLFHRNYN 374
            :|:                 |:|..|                .|..:|..........:| .:|.
Worm  1188 IPSYASAFRGMTDESIFLGLSRRKTIPNHIPPPNFDLEANGPACASVANNLMQFANGRVF-VDYM 1251

  Fly   375 H---MQMINELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEALKLHFRTHD---DNKL 433
            :   ..:.|..:|....||.|........::|.|:..:|:|||..|...::.:....|   ::.|
Worm  1252 YPTAQDVTNIRKSAGGIIKNVISSFQGMIDQLDWMAPDTKQKAYAKTVQIQQNIAFPDWIKNDTL 1316

  Fly   434 IRQMHG--LILNMDRFYPNLVSVLQWK----------TQRGLAKLMTEPVAEDEVHKLPHYEIQK 486
            :...:.  :|.:.|.||.....::::.          .|......:.:|...:     ..|:.:.
Worm  1317 LGNYYSTLVIADSDNFYDIYDKLIKFNIFVQYNQLNAAQTDRTDFLGQPGTVN-----AWYQPEL 1376

  Fly   487 NRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESS 551
            |.|..|...|...:| :|.:|..:.|..:|::...::.||||..|.::...|....|.|..|.:.
Worm  1377 NSITFPAGILVPPYF-NPNWPPSINYGGMGLVAGHELTHGFDDQGVQWGPTGNLARWMDDNSMAG 1440

  Fly   552 YSRRTQCFQEQYAIF-----VEY-----KGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAE 606
            :...:||...:|:.|     ..|     ||...|.::     :||||.:..|:.||:........
Worm  1441 FKNMSQCVINEYSGFCPLNATNYSPNCVKGPQTQGEN-----IADNGGVHAAFNAYKTHQSLDGP 1500

  Fly   607 TPVIYQRERLP---LLDHDHNQIFYLGYAQLYCTDYPETVERFDEL-----------PEQLRVNT 657
            .|      |||   .....|:|:|::.:||::|     .|.|.|:.           |...||..
Worm  1501 DP------RLPDRLFGQFTHDQLFFMSFAQVWC-----EVRRTDDALYTQIMVDPHSPSMYRVYG 1554

  Fly   658 ALSNSQQFANAYGCSREEKLNARFKCTLY 686
            .:.|...|..|:.|....|......|.::
Worm  1555 TIQNFPAFQTAFNCPLGSKSAPEQHCEVW 1583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	145/740 (20%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	144/733 (20%)
nep-17	NP_001254395.1	PepO	108..833	CDD:226118
		M13	112..830	CDD:189000
		PepO	880..1583	CDD:226118	146/742 (20%)
		M13	884..1581	CDD:189000	145/740 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020