Protein Alignment Nepl15 and nep-1

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_496490.2
• Gene: nep-1 / 174787
• WormBaseID: WBGene00013926
• Length: 754
• Species: Caenorhabditis elegans
• Alignment Length: 797
• Identity: 179/797 - (22%)
• Similarity: 316/797 - (39%)
• Gaps: 165/797 - (20%)

  Fly     5 PLGLLLGAILFSIC-AIDASVPHPLAANYSIDILRLAKAAHIKAY-------------MGDEK-- 53
            |:..|:......:| .:||.   |.|..::.||.:....:..|..             :||.:
 Worm     8 PIVFLISCYALILCGTVDAL---PRAPYFNDDINKTTTTSEDKTVGNTVVEEEKKTYTVGDSEGY 69

  Fly    54 EQA--------------CNNFYNYACANWPRLHP--------ARKSKTRTNYLEELQELYIRKSA 96
            ::|              |::|:.|||..|...||        ::.:.||...|.|:::||
 Worm    70 QEASRLLQKSLNLSLDPCDDFFEYACRAWVDSHPIPDDLTSYSQFTATREKVLAEMRKLY----- 129

  Fly    97 DMLKSATRGAENSADRQLKYFYGSCR-LQTNDTRSALNTLQNVTDFRGGWPEIRVASWYQYEYDW 160
               :..|....:.:...:|..|.:|. .:.::...|.:.|:.:..: |.||.:....|.:..:|.
 Worm   130 ---EDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTY-GYWPMVHNEKWRESTFDL 190

  Fly   161 LQVVANLKRKLGVDIFIGLEVILDYKEEKMHRLKIGAPQFPM---SRRHYL-HPHFEGTREIYER 221
            .::::|..:...|.:|.......|.:......|........:   :|.:|| ...:|...:.|.:
 Worm   191 TKLLSNTIQSRDVSVFFDFGPAEDSRNVSRRLLSFDQGSLGLGYSTRDYYLDEKKYEKQMKAYRK 255

  Fly   222 SIENKLKLYFPEQ----SEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYG 282
            ....|::.|..:.    :|...:....:::..|::.|:.|               .|.|.:..|.
 Worm   256 YTIGKVRYYTEDAGMAVNESKIESDVDEIIAFEKEWAQIL---------------VAEEDRRNYT 305

  Fly   283 SYVDVTRYLQLIFNDNL--YMDLYE--------TP-----------------EDYMSNLVDVIRE 320
            ...:|.|:      |:|  ||.:.:        ||                 .:|:..:..:::.
 Worm   306 KLYNVRRF------DDLKEYMSIIDWKKLTLSTTPFLVHSYLKTNPSIIISDVEYLQKMNTLLQN 364

  Fly   321 TPKLQLANYTM--WKALEALDIAR-------------VPASQRADIW--CVQLAQQFFPHQLESL 368
            |....:.||.:  |....:.:|.:             ....||...|  ||..|.....:...|:
 Worm   365 TDPRIVTNYILLRWAGSWSQEIGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSM 429

  Fly   369 FHRNYNHMQMINELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEALKLHFRTHD---- 429
            :.|.|......|......:|::..||..:.|::   |:..||::.|:.|.:.:.......|
 Worm   430 YVRKYFDANAKNTTLDMITDLQEAFRNMMHAND---WMDAETKKYALEKADQMLKQIGYPDFILN 491

  Fly   430 DNKLIRQMHGLILNMDRFYPNLV-SVLQWKTQRGLAKLMTEPVAEDE-------VHKLPHYEIQK 486
            |.||.....||....:..:..|| ..:||:......:|: |||...|       |:..  |...:
 Worm   492 DEKLDDWYKGLEGAPEDSFSQLVEKSIQWRNNFYYRRLL-EPVNRFEFISSAAVVNAF--YSPTR 553

  Fly   487 NRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESS 551
            |.|..|...||..|| |..:|..|.|..:|.::..::.||||..||::|..|...:|||:|:.|.
 Worm   554 NAIAFPAGILQQPFF-DARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSK 617

  Fly   552 YSRRTQCFQEQYA------IFVEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVI 610
            ::.||||..||||      ..:...||..|.::     :||||.:..|::||:.:|:....
 Worm   618 FNERTQCIIEQYADVKLRGTDLRINGKLTQGEN-----IADNGGIKQAFKAYKSYLEKHGG---- 673

  Fly   611 YQRERLPLLDH-DHNQIFYLGYAQLYC-TDYPETVERF----DELPEQLRVNTALSNSQQFANAY 669
             |..|||..:. .:.|:|::||||::| ...|||....    ...||..||||.|:|..:||.|:
 Worm   674 -QEARLPQFESLTNEQLFFVGYAQVWCGAKTPETKTLLLLTDPHSPETARVNTVLTNQPEFAEAF 737

  Fly   670 GCSREEKLNARFKCTLY 686
            .|.....:|...:|.::
 Worm   738 KCPAGSPMNPTKRCVVW 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	166/726 (23%)
nep-1	NP_496490.2	M13	85..751	CDD:341056	165/712 (23%)