DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-26

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	169/749 - (22%)
Similarity:	297/749 - (39%)	Gaps:	175/749 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DEKEQACNNFYNYACANWPRLHPARKSKTRT-NYLEELQELYIRKSADMLKSATRGAE------- 107
            |:..:.|:|||.:||..|  ::.:...|..: |.|.|.|    |.:.|.:..|.....
Worm   121 DQSVEPCDNFYQFACGGW--INQSVNLKYDSWNTLYETQ----RTAHDQIVQAMHKINDGSYPLP 179

  Fly   108 -NSADRQLKYFYGSCRLQTNDT--RSALNTLQNVTDFRGGW-PEIRVASWYQYEYDWLQVVANLK 168
             |:.:|.....|..|  ...||  ::.|:..:...|..||| ||::..:..|.|...:::..:.|
Worm   180 TNAGERAAAKMYEQC--MDTDTLEQTGLHLWERFVDELGGWMPELKNGALEQEESFEIELDEDEK 242

  Fly   169 RKLGVDI----------------FIGLEVILDYKEEKMHRLKIGAPQFPM----SRRHY------ 207
            ::...:|                :.|:||  :|...|.|.:.| ..|.|:    .:.||
Worm   243 KRRRFEIEDIILSAFNYSVFPLFWAGVEV--NYLNSKEHLITI-YEQLPILLAPEKYHYNKELTP 304

  Fly   208 --LHPHFEG---TREIYERSIENKLKLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQ 267
              ::...||   ||.:.:...|....|.|....|..|..:|: ::.:|.|          :|:|.
Worm   305 EMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIAN-MIYLEYQ----------ITMAG 358

  Fly   268 TTRQRTAAEMKTAYGSYVDVTRYLQLI--------FNDNLYMDLYETPE-----------DYMSN 313
            :|..:...|..|     |.:.|.||.|        |...|..:.....|           ..:|.
Worm   359 STFYKEKKERYT-----VVMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALKTGTQWIPILSA 418

  Fly   314 LVDVIRETPK--LQLANYTMWKAL-----------------EALDIARVPASQRADIWCVQLAQQ 359
            :|:.::::..  ..|.||..||.:                 .|:.:....||||.: :||.....
Worm   419 IVEKLKQSRSGVAVLKNYVKWKTIMFHLAYASPKCRDGLLWMAVSLYSGAASQRKE-FCVLRLSG 482

  Fly   360 FFPHQLESLFHR--NYNHMQM-INELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKL--- 418
            .||..|.|:..:  ..:|.:. :..:|:....|:..:.|.:::|.  |:...|||:..|.|:
Worm   483 IFPLSLPSILRKIDGIDHTEKNVKAVQNIADRIQEKYEEMVRSSN--LFSDRETRENVIDKVNNM 545

  Fly   419 ------------------EALKLHFRTHDDNKLIRQMHGLILNMDRFYPNLV----SVLQWKTQR 461
                              ||::||                    |..:.::|    ||.:.:.||
Worm   546 TKFIGFPDAMRSDYEMEKEAVRLH--------------------DTLFWSMVLGSSSVYKERLQR 590

  Fly   462 GLAKLMTEP---VAEDEVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQM 523
              .:|..:|   |.......:|.:..::|.:|:|...|:..:. |....:...||.:|.::..::
Worm   591 --LRLPVDPRSWVDTRPAISVPAHNYERNLVQIPFDSLRLPYA-DEHQLDFANYAGIGTIIGHEL 652

  Fly   524 LHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQDKDLLRRIVADNG 588
            .|.|||.|:.:...|....||...|...:..|.|||.:|||..::........:.|...| ||..
Worm   653 THAFDGQGKLHGPTGNLGVWWSTDSIREFKAREQCFVKQYAGLMDSHDMNAAKEGLYENI-ADQV 716

  Fly   589 ALDIAYRAYQQWLKNAAETPVIYQRERLPLLD-HDHNQIFYLGYAQLYCTDYPETVERFDELPEQ 652
            .|.:||.|   |..|..:     ...|:|.|: :..:|:|:|.|.|.:|....::.:....:.|:
Worm   717 GLKVAYEA---WKSNGNQ-----NSGRMPGLEKYSQDQLFFLAYTQGWCALRSKSYKLQPHMEER 773

  Fly   653 LRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :|:..:|.||.:||:|:.||.|..:|...||:::
Worm   774 IRMLGSLQNSPEFASAWKCSSESFMNPPDKCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	167/739 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	165/732 (23%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	169/747 (23%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	167/742 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020