Protein Alignment Nepl15 and nep-5

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 155/752 - (20%)
• Similarity: 261/752 - (34%)
• Gaps: 203/752 - (26%)

  Fly     8 LLLGAILFSICAI---DASV----PHPLAA---------------NYSIDILRLAKAAHIKAYMG 50
            ::|..::|::.|:   |.|.    |.|..|               .||.::|.|.
 Worm    70 VILVLLIFALGALGLHDISAFKWEPKPQKALRIMLDLPCQTKECVKYSAELLELM---------- 124

  Fly    51 DEKEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLK 115
            |.....|.||:::.|..:   :|.:|...|...|..:||          |...|.|.|...|.|
 Worm   125 DSSVNPCENFHHHVCNGF---NPRKKDFERLMKLINIQE----------KPDHRKAVNVVRRML- 175

  Fly   116 YFYGSCRLQTNDTRSALNTLQNVTDFRGGWP-EIRVASWYQ-------------YEYDWL-QVVA 165
               ..|.:...:....:..|.::  ...|.| .:...||.:             |.|.:| :::|
 Worm   176 ---SKCAMGKTEEIHQVGRLSSI--ILPGLPFPLLNNSWTKPSDPISTSNSSTTYSYPFLTKILA 235

  Fly   166 NLKRKLGVDI-FIGLE-----------------VILDYKEEKMHR-LKIGAPQFPMSRRHYLHPH 211
            ::......|. |:|::                 |:.::|...|:. ||..||
 Worm   236 HIILHNPDDAGFVGIKPSSDSEFSLFVVKPFSPVLTNFKFRNMYDILKRNAP------------- 287

  Fly   212 FEGTREIYERSIENKLKLYFPEQSEHWRQEVASQVVQIEQQLAK-GLPHNP-ALTLAQTTRQRTA 274
                    |.|....:.|.|.      ||...:.|::::.:|.| ....:| .:.|.:..||...
 Worm   288 --------ESSTNGMIDLEFD------RQRQLNDVIKLQTKLEKIEFKADPEVVNLTEIQRQMPI 338

  Fly   275 AEMKTAYGSYVDVTRYLQLIFNDNLYMDL----YETPEDYMSNLVDVIRETPKLQLANYTMWKAL 335
            .:.|....|::           .|.|..|    |.....|...:..:|..||...:.|:...:.
 Worm   339 IDWKRLIDSWI-----------PNGYAHLKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLRF- 391

  Fly   336 EALDIARVPASQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSD-IKRVFREDLQA 399
             :....|...:...:..|:.......|.::..........:.::|.:..|..| :||       :
 Worm   392 -SFKFLRTEVASDLEDTCLHQLSTTIPGKIVLYGSEEPEALNLLNGMLHTIKDQLKR-------S 448

  Fly   400 SERLLWLT---LETRQKAITKLEALKLHFRTHDDNKLIRQMHGLILNMDRFYPNLVSVLQWKTQR 461
            ...|.|:.   :|..||...|.:.: ..|...|   ||.::.|.|.....:...|.:||.|:|:.
 Worm   449 LATLKWMDSRGIEEAQKKFNKTKTV-FGFTGED---LIDELVGKITPESNYISTLQNVLLWQTRN 509

  Fly   462 GLAKLMTEPVAEDEV----HKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQ 522
                 |.:.|||:.|    :....|.::||.|.:....|...|. ....||...:||:...:..|
 Worm   510 -----MFKSVAENNVTVFLNSEVFYSVEKNEITISRALLHYPFM-SANLPNYTNFATIASKILPQ 568

  Fly   523 MLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCF----QEQYAIFVEYKGKPVQDKDLLRRI 583
            |:|.||..||.||:.|...|||:..:|..:....|||    |..:.:
 Worm   569 MIHIFDERGRFYDSDGNHRNWWNTETERYFQIIVQCFDGMMQNVFGV------------------ 615

  Fly   584 VADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDYPETVERFDE 648
                 ::.|.:.||....:..|..|.|.|        .....:|:....:..||..|:
 Worm   616 -----SVSIGWNAYDSTKEPYATLPGIQQ--------SSDEALFFYSMVKTMCTSDPD------- 660

  Fly   649 LPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTL 685
                 .||.||::..||.:|:.|:...|:|...||.|
 Worm   661 -----NVNEALASVPQFNSAFKCNNGTKMNPPTKCKL 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	140/679 (21%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	140/681 (21%)