Protein Alignment Nepl15 and nep-12

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 763
• Identity: 172/763 - (22%)
• Similarity: 312/763 - (40%)
• Gaps: 133/763 - (17%)

  Fly     8 LLLGAILFSICAIDA-SVPHPLAANYSID--------ILRLAKAAHIKAYMGDEKEQA--CNNFY 61
            |:.|:.|.|....|| .|.:....||..|        .:|||     .:|:.:....|  |.:||
 Worm   119 LISGSELCSNTEGDAYEVKNSNHVNYGSDNSTCLTPECIRLA-----ASYLNNMNRDANPCEDFY 178

  Fly    62 NYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLK---YFYGSCRL 123
            .:||..:.......:.:.:...|.|:::...|...|:|:..:|  ||:. |.:|   .::.||..
 Worm   179 EFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSR--ENTT-RSMKLAQIYFDSCMD 240

  Fly   124 QTNDTRSALNTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGLEVILDYKEE 188
            :.:.....:..|.::....||||.:..|.:...::.| :|:|......|||....:.|...:.:.
 Worm   241 EFSQDDLGVQPLMSMISNLGGWPLLTNARFDSIDFQW-EVLAGHLALYGVDGIFRVFVHSSFDDS 304

  Fly   189 KMHRLKIGAPQFPMSRRHYLH--PHFEGTREIYERSIENKLKLYFPEQSEHWR--QEVASQVVQI 249
            ..:.|....|:..:.::.:..  |......:.|.:.|.:.|.|...:..:...  :.....::..
 Worm   305 DKNVLMFSPPKLFLEKKKFYREVPSSNVYLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDF 369

  Fly   250 EQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQL----IFNDNLYMDLYETPEDY 310
            |:::|.       ||..:.:|..::......:|.:  ..:|.::    .||:.:..:|...|:..
 Worm   370 ERRIAN-------LTRIELSRNHSSINNMITFGEF--KRKYDKINWDAFFNEEMRGNLGRMPDSL 425

  Fly   311 MSNLVDV---------IRETPKLQLANYTMWKALEALDIARVPASQRA----------------D 350
            :.|:|||         |:..|...:.|:.||..:...|: .:||..|.                .
 Worm   426 VINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDM-YLPAKYRKPMLDFRQKMYGVSSDDP 489

  Fly   351 IW--CV-------------QLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQAS 400
            :|  ||             :.||:||..: :.|...:     ||.       |:|:...:.|..:
 Worm   490 LWEVCVGEVRENLAMPLSTEYAQKFFTKK-DKLVAED-----MIR-------DLKKAMEQTLLNA 541

  Fly   401 ERLLWLTLETRQKAITKLEAL--KLHFRTH--DDNKLIRQMHGLILNMDRFYPNLVSVLQWKTQR 461
            :   |:...||:.|:.||:|:  |:.|...  ::..::....|:.|..::::.|.:|:.:...:.
 Worm   542 D---WIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVRLTANQYFDNAISLKKAAYRD 603

  Fly   462 GLAKLMTEP---------VAEDEVHKLPHYEIQKNRIQVPITFLQARFFWD--PAYPNGLKYATL 515
            .|:||...|         :|.|..|     ....|.|..|...||...|..  ||:.|   |..:
 Worm   604 ALSKLHRTPSLIDWASPIIAVDAFH-----YFTGNEIIFPAGILQFPMFVPDAPAFSN---YGAI 660

  Fly   516 GVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVE-YKGKPVQDKDL 579
            |:.:..::.||:|.:|.:||..|....||...:.:::.::.|||..||...:| ..|:.|..|..
 Worm   661 GMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRKVDGKMT 725

  Fly   580 LRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLP-LLDHDHNQIFYLGYAQLYCTDY-PET 642
            :...:||||.|.:|::|||.......||      .||| |.|...||:|:|.||..:|... |..
 Worm   726 IGENIADNGGLRVAFQAYQLRSDREKET------RRLPGLTDFSPNQLFFLAYANTWCEALKPSA 784

  Fly   643 VERFDELP----EQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            ::...:..    ...|||..|.|...|:..:.|.....:|...||.::
 Worm   785 IDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	157/702 (22%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	157/702 (22%)