DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and Mme

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	760	Identity:	193/760 - (25%)
Similarity:	321/760 - (42%)	Gaps:	113/760 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLGLLLGAILFSICAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYAC 65
            ||.:.| ::|..:..|.|.....|.|.|...|.:    :..||.:...| |...:.|.:|:.|||
Mouse    26 PLEISL-SVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNM-DASVEPCTDFFKYAC 88

  Fly    66 ANWPRLHPARKSKTRTNYLEELQ-ELYIRKSADMLKSATRGAENS---ADRQLKYFYGSCRLQTN 126
            ..|.:.:...::.:|.:..:.|: ||.:     :||...:..:..   |.::.|..|.||..::.
Mouse    89 GGWLKRNVIPETSSRYSNFDILRDELEV-----ILKDVLQEPKTEDIVAVQKAKTLYRSCINESA 148

  Fly   127 -DTRSALNTLQNVTDFRGGWPEIRVAS--WYQ-YEYDWL--QVVANLKRKLGVDIFIGLEVILDY 185
             |:|.....|:.:.|.. |||   |||  |.| |...|.  :.:|.|..|.|..:.|...|..|.
Mouse   149 IDSRGGQPLLKLLPDIY-GWP---VASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDD 209

  Fly   186 KEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREIY--------------------ERSI---ENKL 227
            |....|.:....|:..:..|.|    :|.| .||                    |:|:   ||:|
Mouse   210 KNSTQHIIHFDQPRLGLPSRDY----YECT-GIYKEACTAYVDFMISVARLIRQEQSLPIDENQL 269

  Fly   228 KLYFPEQSEHWRQEVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQ 292
            .|...:..| ..:|:|:...:.|.:....|.:| .:|||: .:...:.|:.....|:.:.|..:.
Mouse   270 SLEMNKVME-LEKEIANATTKPEDRNDPMLLYN-KMTLAK-LQNNFSLEVNGKSFSWSNFTNEIM 331

  Fly   293 LIFNDNLYMD---LYETPEDYMSNLVDVIRETPKLQLANYTMWKAL---------------EALD 339
            ...|.|:..:   :...|| |::.|..::.:.....|.|...|:.:               .|..
Mouse   332 STVNINIQNEEEVVVYAPE-YLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFR 395

  Fly   340 IARVPASQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSD----IKRVFREDLQAS 400
            .|....:.....|  :....:....:|:...|.|.......|.:....|    |:.||   :|..
Mouse   396 KALYGTTSETATW--RRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVF---IQTL 455

  Fly   401 ERLLWLTLETRQKAITKLEALKLHFRTHDD-----NKLIRQMHGLILNMDRFYPNLVSVLQWKTQ 460
            :.|.|:..||::||..|..|:|......||     |||..:...|....|.::.|::..|::...
Mouse   456 DDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQS 520

  Fly   461 RGLAKLMTEPVAEDE-------VHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVL 518
            :.|.|| .|.|.:||       |:..  |...:|:|..|...||..|| .....|.|.|..:|::
Mouse   521 KQLKKL-REKVDKDEWISGAAVVNAF--YSSGRNQIVFPAGILQPPFF-SAQQSNSLNYGGIGMV 581

  Fly   519 LARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV--EYKGKPVQDKDLLR 581
            :..::.||||..||.::..|...:||...|.:::..::||...||..|.  ...|:.:...:.|.
Mouse   582 IGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLG 646

  Fly   582 RIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE---- 641
            ..:||||.:..||||||.::|...|      .:.||.||.:|.|:|:|.:||::|..| ||
Mouse   647 ENIADNGGIGQAYRAYQNYVKKNGE------EKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVN 705

  Fly   642 TVERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :::.....|...|:...|.||.:||:|:.|.:...:|...||.::
Mouse   706 SIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	178/700 (25%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	176/693 (25%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	178/703 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850