DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-3

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_494679.2	Gene:	nep-3 / 173730	WormBaseID:	WBGene00016778	Length:	634	Species:	Caenorhabditis elegans

Alignment Length:	723	Identity:	161/723 - (22%)
Similarity:	269/723 - (37%)	Gaps:	157/723 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLGLLL-----GAILFSIC---AIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFY 61
            ||.|||     |..:...|   :..::.|.|.....:.:.:.|   .|......|.....|.|||
Worm    28 PLVLLLEAGKIGGEVSENCSNHSTSSASPKPKPMCLTPECITL---VHQLLNFQDPSVDPCENFY 89

  Fly    62 NYACANWPRLHPARKSKTRTNYLEELQELYIRKSADML---KSATRGAENSADRQLKYFYGSCR- 122
            ..||..:...:....|:|     .:.|::..|...|.|   :|:|..:|||    :|..|..|:
Worm    90 QAACGKYNEHNVIDGSRT-----AQKQQIVKRLIRDFLHKNQSSTSKSENS----MKLLYEKCKE 145

  Fly   123 LQTNDTRSALNTLQNVTDFR-----GGWPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGLEVI 182
            .:|.......|.||.:  |.     |.|| :...:|...:::..:::.:|.| |||..|...|:|
Worm   146 AKTIKVLGNQNLLQEI--FMNIQKIGSWP-VLDENWDGKKFNLNEMLLSLIR-LGVSNFGFFEII 206

  Fly   183 LD---YKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPEQSEHWRQEVAS 244
            :.   :.|.|..|      .||             |||..                    .::.|
Worm   207 ISSDAFVEIKPAR------NFP-------------TRENL--------------------SDIIS 232

  Fly   245 QVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYETPED 309
            :|.     |..|...|                              :..|.||   :..||..:.
Worm   233 KVF-----LGNGFQPN------------------------------ITAIEND---LREYENLQR 259

  Fly   310 YMSNLVDVIRETPKLQLANYTMWKALEA--LDIARVPASQRADIWCVQLAQQFFPHQLESLFHRN 372
            .:.:|..:|:.||...|.||.::..|::  |:..|:|..|     |..:...|.|.....:|.:|
Worm   260 ELKSLERLIQTTPNRSLVNYLIFNYLKSVMLEYKRLPEEQ-----CEGVVIDFLPRASTRVFVQN 319

  Fly   373 YNHMQMINELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEALKLHFRTHD----DNKL 433
            :...:....:.....|:|..|.:.:|.|   .||..|:::.|:.|::.:|......|    ...|
Worm   320 FLDKENRKYVAGMIEDVKMGFIDMIQES---TWLNEESKKVAVQKVKNIKSMIGYPDFFEPPGTL 381

  Fly   434 IRQMHGLILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDE----VHKLPHYEIQKNRIQVPIT 494
            .|....|.:.....|..:|..:|..|.....:.:...:..|.    :|....|: ..|.:.:...
Worm   382 DRSFKDLNIEQTDSYHTIVRKIQKFTNEQCMEFVASEIPLDPRQPILHANAFYQ-NTNFLAILAP 445

  Fly   495 FLQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCF 559
            .|....| |..:|..:..|.:|.:||.::.|.||..|..||..|.:..|........|.:|.:|.
Worm   446 VLDDPIF-DTTFPRYVNLAVIGNVLAHEIGHAFDHTGINYDDAGQQRIWLTPEDSEEYGKRLRCL 509

  Fly   560 QEQYAIFVEYK----GKPVQDKDLLRRIVADNGALDIAYRAYQQW-LKNAAETPVIYQRERLPLL 619
            ..|:.   ||.    |:.:.....|..|.||...::.|:|.:::. |.|.:|. |.:|...:
Worm   510 LRQHD---EYDDPDFGRNLNGSKTLHEISADRFGVEAAWRTFKKLDLSNESEI-VGFQNFNI--- 567

  Fly   620 DHDHNQIFYLGYAQLYC-----TDYPETVERFDELP-EQLRVNTALSNSQQFANAYGCSREEKLN 678
                :|:::...|.::|     ||....::|  |.| ...|||...:|..|||..:.|.....:|
Worm   568 ----DQLYFRTAALIWCRQRDTTDLQYALQR--EHPTNNFRVNGIYANMPQFAETFNCPLGSPMN 626

  Fly   679 ARFKCTLY 686
            .:.||.|:
Worm   627 PKKKCDLF 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	147/659 (22%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	145/652 (22%)
nep-3	NP_494679.2	M13	82..631	CDD:189000	146/661 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920