DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and nep-13

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001342017.1	Gene:	nep-13 / 173672	WormBaseID:	WBGene00018196	Length:	732	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	162/761 - (21%)
Similarity:	305/761 - (40%)	Gaps:	160/761 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGLLLGAILF---------SICAIDASVPHPLAANYSIDILRLAKAAHIKAYM---GDEKEQACN 58
            :.:.:||::.         :||..|    |    |.:.|:.:.|:...:.:.:   .:.....|.
Worm    52 IAICMGAVIVFWRMDSAPQAICKTD----H----NKTRDVCKTAECITLSSTLLNWQNTNIDPCE 108

  Fly    59 NFYNYACANWPR--LHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYFYGSC 121
            :||.|:|..:..  |:...::..:...:.:|...::.|:    :|.|..:||:    |...|..|
Worm   109 DFYEYSCGRYQEHTLNDGIRANEKDTIVMKLIRQFVLKN----QSTTSNSENA----LMLLYEKC 165

  Fly   122 ----RLQTNDTRSAL---NTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGVDIFIGL 179
                |::.....:.:   ...:|:... |.|| |...:|....::...:::|:
Worm   166 SLRYRMENRHQETEVIQREVFENIRKI-GSWP-IADKNWNSSHFNLNNMLSNM------------ 216

  Fly   180 EVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPEQSEHWR----- 239
                    ..:|.|..|..:   :|...|:|.....:::..|  ..|||...| |.|..|
Worm   217 --------ASIHMLPFGLFE---TRVIELYPMNTTAKQLVIR--PTKLKFSIP-QEELVRAIRDL 267

  Fly   240 ---QEVASQVVQIEQQLAKGL------------PHNPALTLAQTTRQRTAAEMKTAYGSYVD--- 286
               ..:.|.:.::::.:|:..            |.....||::..:.....:.:....||::
Worm   268 LSVNGITSIMKKVKEDVAESFALDKEIGNIHIDPQPKPATLSELQKAVPDIDFERIIKSYLNPKT 332

  Fly   287 ----------VTRYLQLIFNDNLYMDLYETPEDYMSNLVDVIRETPKLQLANYTMWKALE----- 336
                      .:...:|.|..|             :||..:|..|....||||...|.:|
Worm   333 GNWSSLRTKIFSARFELFFGKN-------------NNLSSIIARTKPRILANYLFLKYIEYAYFF 384

  Fly   337 ALDIARVPASQRADIWCVQLAQQFFPHQLESLFHRNY---NHMQMINELQSTWSDIKRVFREDLQ 398
            ..|..:|.:.   |.:|.::.....|.....:|.||:   .:|.:.:|:...   :|..:.|.:.
Worm   385 FFDNTKVFSD---DDFCTEVVTTSLPRASLRVFVRNHFKKENMAVASEIVEV---VKTAYVEIIN 443

  Fly   399 ASERLLWLTLETRQKAITKLEALKL-------HFRTHDDNKLIRQMHGLILNMDRFYPNLVSVLQ 456
            .|   .||...||:.||.|:..:|.       :.||...:::...:.  :...|.|:..:..|.:
Worm   444 NS---TWLHNSTRESAIEKVVKMKKVIGYTEEYERTGALDEMFETLQ--LSRSDSFFVLMTKVNR 503

  Fly   457 WKTQRGL----AKLMTEPVAEDEVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGV 517
            :|.::.:    :..:..|: |..|.....|...||.:.|.:.||....| |..||..:..|.:|.
Worm   504 FKIEQLMDFVSSDSLLNPI-EPLVMANAFYFPTKNLLNVLVPFLDKPLF-DFKYPRYVAMAGVGR 566

  Fly   518 LLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVE--YKGKPVQDKDLL 580
            :||.::.|.||..||:.|..|...:||.......|.||::||.||:..|.:  :|||. ...::|
Worm   567 VLAHEIGHAFDINGRQTDEIGRTRDWWTREDTEEYDRRSECFAEQFTNFKDPSFKGKQ-NGTEVL 630

  Fly   581 RRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDYPETV-E 644
            ..|:||...::.::.|:::  .|..|...:.|.|     |||..::::...|..:|.  |..: |
Worm   631 AEIIADALGMEASWIAFKK--INLTEEQGLIQFE-----DHDFGKLYFQVAALDFCA--PSRIEE 686

  Fly   645 RF-DEL---PEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            |: |:|   ..:.|:|.|.|||:.||:.|.|....|:|...:|.::
Worm   687 RYSDQLSHPTNKFRINGAFSNSRAFADTYKCPVGSKMNPVQRCDMF 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	152/694 (22%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	150/687 (22%)
nep-13	NP_001342017.1	M13	104..729	CDD:189000	152/696 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920