DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001264854.1	Gene:	Ecel1 / 13599	MGIID:	1343461	Length:	775	Species:	Mus musculus

Alignment Length:	790	Identity:	179/790 - (22%)
Similarity:	311/790 - (39%)	Gaps:	188/790 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGAILFS--ICAIDASVPHPLAANYSIDIL-------------------RLAKAAHIKAYMGDE 52
            ||..::|:  :|||       |||..::..|                   ..|:||...:...|.
Mouse    62 LLSGLVFAAGLCAI-------LAAMLALKYLGPGAAGGGGACPEGCPERKAFARAARFLSANLDA 119

  Fly    53 KEQACNNFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLKSATRGAENSADRQLKYF 117
            ....|.:||::||..|.|.|.....|.....:..:.|....:...:|...|.|...:|.|:::.|
Mouse   120 SIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAF 184

  Fly   118 YGSCRLQTNDTRSALNTLQNVTDFRGGW------PEIRVASWYQYEYDWLQVVANLKRKLGVDIF 176
            :.||.......|.....:..|.:..|||      .....|.|     |..:::...:........
Mouse   185 FRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAADRPGAARW-----DLNRLLYKAQGVYSAAAL 244

  Fly   177 IGLEVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREI---YERSIENKLKLYFPEQSEHW 238
            ..|.|.||.:....:.::|......:..|.......|.:.:|   |...::..|:|...:..|
Mouse   245 FSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKILAAYRVFMQRLLRLLGADAVE-- 307

  Fly   239 RQEVASQVVQIEQQLAKGLPHNPALTLAQ---TTRQRTAAEMKTAYGSYVDVTRYLQ---LIFND 297
              :.|.:::|:||:||.       :::::   ..|..::|..|...|....:..:||   |:  |
Mouse   308 --QKAQEILQLEQRLAN-------ISVSEYDDLRRDVSSAYNKVTLGQLQKIIPHLQWKWLL--D 361

  Fly   298 NLYMDLYETPE-------DYMSNLVDVIRETPKLQLANYTMWKAL------------EAL----- 338
            .::.:.:...|       |||..:..:||.||:..|.||.:|:.:            |||
Mouse   362 QIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSSPFREALHELAK 426

  Fly   339 ---------DIARVPASQRADIWCVQLAQQFFPHQLESLF-HRNYNHMQMINELQSTWSDIKRVF 393
                     ::|||         |:..|.:.|...|.:|| |.:::..... ::|....|||.:.
Mouse   427 EMEGNDKPQELARV---------CLGQANRHFGMALGALFVHEHFSAASKA-KVQQLVEDIKYIL 481

  Fly   394 REDLQASERLLWLTLETRQKAITKLEAL------------------KLHFRTHDDNKLIRQMHGL 440
            .:.|   |.|.|:..:|:..|..||:.:                  :..|..|:..
Mouse   482 GQRL---EELDWMDAQTKAAARAKLQYMMVMVGYPDFLLKPEAVDKEYEFEVHEKT--------- 534

  Fly   441 ILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDEVHK----LP------HYEIQKNRIQVPITF 495
                  ::.|:::.:::..|..:.|:      ..||.|    ||      :|...||::..|...
Mouse   535 ------YFKNILNSIRFSIQLSVKKI------RQEVDKSSWLLPPQALNAYYLPNKNQMVFPAGI 587

  Fly   496 LQARFFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQ 560
            ||...: ||.:|..|.|..:|.::..::.||:|..|.:||..|...:||..||.|.:.|:.:|..
Mouse   588 LQPTLY-DPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTETSYSHFLRKAECIV 651

  Fly   561 EQYAIFVEYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLK-NAAETPVIYQRERLPLLDHDHN 624
            ..|..|..|..: |..|..|...:||.|.|.:||.|||:|:: :..|.|       |..|.:.||
Mouse   652 RLYDNFTVYNQR-VNGKHTLGENIADMGGLKLAYYAYQKWVREHGPEHP-------LHRLKYTHN 708

  Fly   625 QIFYLGYAQLYC-------------TDYPETVERFDELPEQLRVNTALSNSQQFANAYGCSREEK 676
            |:|::.:||.:|             ||        ...||..||..::|..::|..|:.|.::..
Mouse   709 QLFFIAFAQNWCIKRRSQSIYLQVLTD--------KHAPEHYRVLGSVSQFEEFGRAFHCPKDSP 765

  Fly   677 LNARFKCTLY 686
            :|...||:::
Mouse   766 MNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	164/717 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	162/710 (23%)
Ecel1	NP_001264854.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..52
Ecel1	NP_001264854.1	M13	121..773	CDD:341056	164/720 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840