DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl15 and Gm49333

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_808810.1	Gene:	Gm49333 / 110599584	MGIID:	6121518	Length:	910	Species:	Mus musculus

Alignment Length:	762	Identity:	188/762 - (24%)
Similarity:	315/762 - (41%)	Gaps:	154/762 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLGAIL---------FSICAIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNY 63
            ||||.::         .|.|..:|.:   ..|...::.|             |.....|.:||.:
Mouse   220 LLLGCLVALWVHRDPAHSTCVTEACI---RVAGKILESL-------------DRGVSPCQDFYQF 268

  Fly    64 ACANWPRLHPARKSKTRTNYLEEL--QELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTN 126
            :|..|.|.:|....::|.|....|  |...|.|  .:|::.|..:.:.|:|:.:.||.||.....
Mouse   269 SCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILK--HLLENTTFNSSSEAERKTRSFYLSCLQSER 331

  Fly   127 DTRSALNTLQNVTDFRGGWPEIRVASWYQYEY-DWLQVVANLKRKLGVDIFIGLEVILDYKEEKM 190
            ..:.....|:::.|..|||.  ....|.:..: |.|:.||...|   ...|..:.|..|.|....
Mouse   332 IEKLGAKPLRDLIDKIGGWN--ITGPWDEDSFMDVLKAVAGTYR---ATPFFTVYVSADSKSSNS 391

  Fly   191 HRLKIG-APQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPE-------QSEHWRQEVASQVV 247
            :.:::. :..|..||.:||:      |...|:.:...|. |..|       |....|::: .||:
Mouse   392 NIIQVDQSGLFLPSRDYYLN------RTANEKVLTAYLD-YMVELGVLLGGQPTSTREQM-QQVL 448

  Fly   248 QIEQQLAKGLPHNPALTLAQTTR--------QRTAAEMKTAYGSYVDVTRYLQLIFN-----DNL 299
            ::|.|||.       :|:.|..|        :.:.:|:: |....||...:|..:.:     |:.
Mouse   449 ELEIQLAN-------ITVPQDQRRDEEKIYHKMSISELQ-ALAPAVDWLEFLSFLLSPLELGDSE 505

  Fly   300 YMDLYETPEDYMSNLVDVIRETPKLQLANYTMW-------------------KALEALDIARVPA 345
            .:.:|.|  :|:..:.::|..|....|.||.:|                   |.||.|...:...
Mouse   506 PVVVYGT--EYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSC 568

  Fly   346 SQRADIW--CVQLAQQFFPHQLESLFHRNYNHMQ-------MINELQSTWSDIKRVFREDLQASE 401
            :.|   |  |:..........|.|||.:.....|       ||||::|       .|.|.|   .
Mouse   569 TPR---WQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRS-------AFEETL---G 620

  Fly   402 RLLWLTLETRQKAITKLEALK---------LHFRTHDDNKLIRQMHGLILNMDRFYPNLVSVLQW 457
            .|:|:..:||..|..|.:|:.         |..:..||     ...|..::.|.|:.|::::..:
Mouse   621 DLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDD-----VYDGYEVSEDSFFQNMLNLYNF 680

  Fly   458 KTQRGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGV 517
             :.:.:|..:.:|.:.|:....|     :|...||.|..|...|||.|: ...:|..|.:..:||
Mouse   681 -SAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFY-AHNHPKALNFGGIGV 743

  Fly   518 LLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQDKDLLRR 582
            ::..::.|.||..||.||..|....||.:.|.:::...|.|.:|||:.: :..|:.:.....|..
Mouse   744 VMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQY-QVNGERLNGLQTLGE 807

  Fly   583 IVADNGALDIAYRAYQQWL-KNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDYPETVERF 646
            .:||||.|..||.||:.|| |:..|.|       ||.:...::|:|::|:||::|:  ..|.|..
Mouse   808 NIADNGGLKAAYNAYKAWLRKHGEEQP-------LPAVGLTNHQLFFVGFAQVWCS--VRTPESS 863

  Fly   647 DE-------LPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            .|       .|.:.||...||||:.|...:||.....:|....|.::
Mouse   864 HEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	177/700 (25%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	176/693 (25%)
Gm49333	NP_808810.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	248..901	CDD:226118	179/720 (25%)
		M13	259..908	CDD:189000	177/703 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841081
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850