Protein Alignment Nepl15 and Ece2

DIOPT Version :10

• Sequence 1: NP_651098.2
• Gene: Nepl15 / 42701
• FlyBaseID: FBgn0039024
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 762
• Identity: 188/762 - (24%)
• Similarity: 315/762 - (41%)
• Gaps: 154/762 - (20%)

  Fly     8 LLLGAIL---------FSICAIDASVPHPLAANYSIDILRLAKAAHIKAYMGDEKEQACNNFYNY 63
            ||||.::         .|.|..:|.:   ..|...::.|             |.....|.:||.:
Mouse    73 LLLGCLVALWVHRDPAHSTCVTEACI---RVAGKILESL-------------DRGVSPCQDFYQF 121

  Fly    64 ACANWPRLHPARKSKTRTNYLEEL--QELYIRKSADMLKSATRGAENSADRQLKYFYGSCRLQTN 126
            :|..|.|.:|....::|.|....|  |...|.|  .:|::.|..:.:.|:|:.:.||.||.....
Mouse   122 SCGGWIRRNPLPNGRSRWNTFNSLWDQNQAILK--HLLENTTFNSSSEAERKTRSFYLSCLQSER 184

  Fly   127 DTRSALNTLQNVTDFRGGWPEIRVASWYQYEY-DWLQVVANLKRKLGVDIFIGLEVILDYKEEKM 190
            ..:.....|:::.|..|||.  ....|.:..: |.|:.||...|   ...|..:.|..|.|....
Mouse   185 IEKLGAKPLRDLIDKIGGWN--ITGPWDEDSFMDVLKAVAGTYR---ATPFFTVYVSADSKSSNS 244

  Fly   191 HRLKIG-APQFPMSRRHYLHPHFEGTREIYERSIENKLKLYFPE-------QSEHWRQEVASQVV 247
            :.:::. :..|..||.:||:      |...|:.:...|. |..|       |....|::: .||:
Mouse   245 NIIQVDQSGLFLPSRDYYLN------RTANEKVLTAYLD-YMVELGVLLGGQPTSTREQM-QQVL 301

  Fly   248 QIEQQLAKGLPHNPALTLAQTTR--------QRTAAEMKTAYGSYVDVTRYLQLIFN-----DNL 299
            ::|.|||.       :|:.|..|        :.:.:|:: |....||...:|..:.:     |:.
Mouse   302 ELEIQLAN-------ITVPQDQRRDEEKIYHKMSISELQ-ALAPAVDWLEFLSFLLSPLELGDSE 358

  Fly   300 YMDLYETPEDYMSNLVDVIRETPKLQLANYTMW-------------------KALEALDIARVPA 345
            .:.:|.|  :|:..:.::|..|....|.||.:|                   |.||.|...:...
Mouse   359 PVVVYGT--EYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSC 421

  Fly   346 SQRADIW--CVQLAQQFFPHQLESLFHRNYNHMQ-------MINELQSTWSDIKRVFREDLQASE 401
            :.|   |  |:..........|.|||.:.....|       ||||::|       .|.|.|   .
Mouse   422 TPR---WQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMINEIRS-------AFEETL---G 473

  Fly   402 RLLWLTLETRQKAITKLEALK---------LHFRTHDDNKLIRQMHGLILNMDRFYPNLVSVLQW 457
            .|:|:..:||..|..|.:|:.         |..:..||     ...|..::.|.|:.|::::..:
Mouse   474 DLVWMDEKTRLAAKEKADAIYDMIGFPDFILEPKELDD-----VYDGYEVSEDSFFQNMLNLYNF 533

  Fly   458 KTQRGLAKLMTEPVAEDEVHKLP-----HYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGV 517
             :.:.:|..:.:|.:.|:....|     :|...||.|..|...|||.|: ...:|..|.:..:||
Mouse   534 -SAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFY-AHNHPKALNFGGIGV 596

  Fly   518 LLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQDKDLLRR 582
            ::..::.|.||..||.||..|....||.:.|.:::...|.|.:|||:.: :..|:.:.....|..
Mouse   597 VMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQNHTACMEEQYSQY-QVNGERLNGLQTLGE 660

  Fly   583 IVADNGALDIAYRAYQQWL-KNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDYPETVERF 646
            .:||||.|..||.||:.|| |:..|.|       ||.:...::|:|::|:||::|:  ..|.|..
Mouse   661 NIADNGGLKAAYNAYKAWLRKHGEEQP-------LPAVGLTNHQLFFVGFAQVWCS--VRTPESS 716

  Fly   647 DE-------LPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            .|       .|.:.||...||||:.|...:||.....:|....|.::
Mouse   717 HEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	56..684	CDD:341056	177/701 (25%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	177/703 (25%)