DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and mme

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_031758820.1	Gene:	mme / 101734885	XenbaseID:	XB-GENE-1011098	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	779	Identity:	183/779 - (23%)
Similarity:	326/779 - (41%)	Gaps:	148/779 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PL--GLLLGAILFSICAIDASVPHPLAANYSIDILR--LAKAAHIKAYMGDEKEQACNNFYNYAC 65
            ||  ||::..|...|.:| |.:.....:|..|...:  ::.||.|.|.| |.....||:||.|||
Frog    19 PLEKGLIILCIFLGIISI-AMILAYATSNDGICTSQACISTAARIIANM-DAATDPCNDFYQYAC 81

  Fly    66 ANWPRLHPARKSKTRTNYLEELQELYIRKSAD-MLKSATRGAENSAD-----RQLKYFYGSCRLQ 124
            ..|     .:|::...|.:.......:|...: :||.|..  :.|||     :::|.||.||..:
Frog    82 GGW-----LKKNRIPDNNIVSNTFDILRTDIEVVLKDALE--KESADDIPAIKKVKTFYKSCIDE 139

  Fly   125 T-NDTRSA---LNTLQNVTDFRGGWPEIRVASW-YQYEYDW--LQVVANLKRKLGVDIFIGLEVI 182
            | .:.|..   :.||..:.|    || |.|.:| .:|...|  .:.:|....|.|....|.:.|.
Frog   140 TIKNLRKGGPLIKTLPALYD----WP-IAVDNWETRYGLVWSAQESIAGFITKYGQSGLINVYVS 199

  Fly   183 LDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTREI----YERSIENKLKLYFPEQSEHWRQE-V 242
            .|......:.|.|..|...:..:.|.  ..:||.||    |...:.:...|...|::....:: :
Frog   200 EDLTNSSTYILHIDQPGLGLPSKDYY--DCKGTSEIACLAYMEQMVSVAMLIRKERNLTINEDKI 262

  Fly   243 ASQ---VVQIEQQLAKG-----LPHNPALTLAQTTRQRTAAEMKTAY------------------ 281
            .|:   |.::|:::||.     :..|    |....::.|.:.:...|
Frog   263 LSEMEKVFKLEREIAKAEASEEIREN----LNDIYKKMTLSGIAKTYPLKMNDQNINWLKLINAI 323

  Fly   282 ----GSYVDVTRYLQLIFNDNL----YMDLYETPEDYMSNLVDVIRETPKLQLANYTMWK-ALEA 337
                |..::....:.||.:|.|    :::.|:..|                 |.||..|: .|.|
Frog   324 ISPGGVSIEENEQVALICSDYLKKLRFLNKYKARE-----------------LQNYLGWRYILSA 371

  Fly   338 LDIARVP---------------ASQRADIWCVQLAQQFFPHQLESLFHRNY---------NHMQM 378
            ::...:.               |::.:| |  |....:....:|....|.|         .|:::
Frog   372 INDLSLEYKNTGIHLKKALYGNAAEGSD-W--QTCVTYLNDNMEDAIGRLYLKETLSADIEHVKV 433

  Fly   379 INELQSTWSDIKRVFREDLQASERLLWLTLETRQKAITKLEAL--KLHFRTH--DDNKLIRQMHG 439
            .::::...::|:|.|.|.|   |.:.|:..:|:::|..|:.::  ::.|...  ||.||......
Frog   434 KDKVKEIIAEIRRAFLEML---EEMDWMDEDTKKRAARKVASINERIAFSEDIMDDFKLNEGYSE 495

  Fly   440 LILNMDRFYPNLVSVLQWKTQRGLAKLMTEPVAEDE-----VHKLPHYEIQKNRIQVPITFLQAR 499
            |...:|..:.|....::: .|:.:...:.:.|.::|     .|....|.:..|.|..|...||..
Frog   496 LEFRVDELFENKQKYIEF-VQKKMTSRLRKQVNKNEWVPGPAHVNAFYSLTYNEIVFPAGILQTP 559

  Fly   500 FFWDPAYPNGLKYATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYA 564
            || ..:.|:.|.|..:|:::..::.||||..|..:|.:|...|||.:.|..::|..:|||..||.
Frog   560 FF-SSSQPSALNYGGIGMIIGHEITHGFDNRGCNFDEHGNLVNWWTNASMMNFSNLSQCFVNQYG 623

  Fly   565 IFV--EYKGKPVQDKDLLRRIVADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIF 627
            .:.  |..|:.:.....|...::|||.:..||||::.::|:..|.      :.||.:|.|.:|:|
Frog   624 NYSWDEAGGQYLNGISTLGENISDNGGIRGAYRAFKNYVKSHKED------DLLPGIDLDSDQLF 682

  Fly   628 YLGYAQLYC----TDYPET-VERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            ::.:.|::|    .:|..| ::.....|...||...|.||.:|:.|:.|.....:|...||.|:
Frog   683 FISFGQIWCGMHRPEYAATLIKTGSHTPGIFRVIGTLQNSPEFSKAFSCCNNAYMNPAVKCKLW 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	165/719 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	163/712 (23%)
mme	XP_031758820.1	M13	71..744	CDD:341056	165/721 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020