DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and ecel1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_012818808.2	Gene:	ecel1 / 100496473	XenbaseID:	XB-GENE-989944	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	759	Identity:	180/759 - (23%)
Similarity:	317/759 - (41%)	Gaps:	132/759 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGAILFSI--CAIDASVPHPLAANY---SIDILRLAKAAHIKAYMG---------DEKEQACNN 59
            ||..::|::  |.|...:   |...|   ..|:..|......||:|.         |.....|.:
Frog    57 LLSGLVFAVGLCVILGCM---LVLKYLSMEQDVQCLEGCQERKAFMRASKFITNNIDPTISPCTD 118

  Fly    60 FYNYACANWPRLHPARKSKTRTNYL--------EELQELYIRKSADMLKSATRGAENSADRQLKY 116
            ||::||..|.|.|...:.|.....:        |:|:.|       :|:...|..:.||:|::|.
Frog   119 FYSFACGGWLRRHGIPEDKLIYGTIAAIGEQNEEKLEHL-------LLQPVRRKHKGSAERKVKE 176

  Fly   117 FYGSC-RLQTNDTRSALNTLQNVTDFRGGW--PEIRVASWYQYEYDWLQVVANLKRKLGVDIFIG 178
            |:.|| .::..|...|...||.:.|. |||  ||.....|     |:.:::...:......:|..
Frog   177 FFKSCLNMRDIDRLGARPMLQVIEDC-GGWDLPEDPRTQW-----DFNELLYKTQGVYSTAVFFS 235

  Fly   179 LEVILDYKEEKMHRLKIGAPQFPMSRRH-YLHPHFEGTR--EIYERSIENKLKLYFPEQSEHWRQ 240
            :.|.||.|....:.::|......:..|. ||....|..:  |.|:..::..|.|...|..    |
Frog   236 MTVSLDDKNSSRYIIRIDQDGLTLPERTLYLGQDEESIKVLEAYKVFMQTILSLLGVENV----Q 296

  Fly   241 EVASQVVQIEQQLAKGLPHNPALTLAQTTRQRTAAEMKTAYGS-----------YVDVTRYLQLI 294
            :.|.:::.:||.|:.       :|:::....|  .::.|.|..           :::....|..|
Frog   297 KKAEEILHLEQHLSN-------ITISEFDDMR--RDISTMYNKVTLAQLQQITPHLNWKNLLNRI 352

  Fly   295 FNDNLYMD--LYETPEDYMSNLVDVIRETPKLQLANYTMWK---------------ALEALDIAR 342
            |:.|...|  :.....|||..:.::||.||...|.||.:|:               |:..|....
Frog   353 FHTNFPEDEEVVVLATDYMQKVSEMIRSTPASVLHNYMLWRIVVVLSEHLSTPFRDAIHELSKEM 417

  Fly   343 VPASQRADIW--CVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQASERLLW 405
            ..:.::|::.  |:..|.:.|...|.:||...|.......::|....:||.:....|   |.|.|
Frog   418 EGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSSKAKVQQLVENIKHILDYRL---EELDW 479

  Fly   406 LTLETRQKAITKLEALKLHFRTHD---DNKLIRQMHGLILNMDRFYPNLVSVLQWKTQRGLAKLM 467
            :..||:|.|..||:.:.:.....|   ..:.:.:.:...:|...::.|:::.:::..:..:.::.
Frog   480 MDTETKQAAREKLKHMMVMIGYPDVLLQPESMDKEYEFEVNEKTYFKNILNSIRYSIKMAVRRIR 544

  Fly   468 TEPVAEDEVHKLP------HYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLARQMLHG 526
            .|  .:.....||      :|...||::..|...||...: ||.:|..|.|..:|.::..::.||
Frog   545 QE--VDKSAWLLPPQALNAYYLPNKNQMVFPAGILQPTLY-DPDFPQSLNYGGIGTIIGHELTHG 606

  Fly   527 FDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQDKDLLRRIVADNGALD 591
            :|..|.:|||.|....||...|.|.:.::.:|..:.|..|..|..: |..:..|...:||.|.|.
Frog   607 YDDWGGQYDANGNPIQWWTEDSYSKFLKKAECIVDLYENFTVYNQR-VNGRTTLGENIADLGGLK 670

  Fly   592 IAYRAYQQWLK-NAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYC-------------TDYPET 642
            :||.|||:|:: |..|.|       ||.|.:.|:|:|::.:||.:|             ||
Frog   671 LAYYAYQKWVRDNGPERP-------LPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTD---- 724

  Fly   643 VERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
                ...||..||..::|..::|...:.|.|...:|...||:::
Frog   725 ----KHAPEHYRVMGSVSQFEEFGRVFHCPRNSPMNPVHKCSVW 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	166/693 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	164/686 (24%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	166/696 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020