DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl15 and mmel1

DIOPT Version :9

Sequence 1:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_012821551.1	Gene:	mmel1 / 100145721	XenbaseID:	XB-GENE-991673	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	758	Identity:	184/758 - (24%)
Similarity:	318/758 - (41%)	Gaps:	122/758 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGAILFSI-CAIDASVPHPLAANYSIDILR----LAKAAHIKAYMGDEKEQACNNFYNYACANWP 69
            |..:||.: ||:.|.:  .|..::...|..    :..||.|...| |...:.|.:||.|||..|.
Frog    49 LSVLLFLMTCAVVALL--VLYTSHKESICTTTGCVTAAARIIQNM-DPTIEPCTDFYQYACGGWL 110

  Fly    70 RLHPARKSKTRTNYLEELQ---ELYIRKSADMLKSATRGAENSADRQLKYFYGSCR----LQTND 127
            ..|...::.:|.:..:.|:   |:.::...:|.....|.|...|    |..|.||.    ::..|
Frog   111 NKHVIPETSSRYSIFDILRDEMEIILKGLLEMPDQEDRDAFKKA----KILYKSCMNESLIEQRD 171

  Fly   128 TRSALNTLQNVTDFRGGWPEIRVAS--WY-QYEYDWLQVVANLKRKLG-----------VDIFIG 178
            :...|..|..|    |.||   |||  |. ..|.:|     :|:.||.           ||||
Frog   172 SLPLLELLTTV----GEWP---VASTDWNGTKESNW-----SLEEKLSLLNYKFNKRVLVDIF-- 222

  Fly   179 LEVILDYKEEKMHRLKIGAPQFPM-SRRHYLHP-HFEGTREIY-------ERSIENKLKLYFPEQ 234
              |..|.:|...|.:.|..|...| ||.:|.:. :::..||.|       .|.:.....|   .:
Frog   223 --VWNDDRESSKHIIYIDQPSLGMPSRDYYFNKGNYQRIREAYLQFMITIARMVREDRNL---TR 282

  Fly   235 SEHWRQEVASQVVQIEQQLAKGLPHNPA---LTLAQTTRQRTAAEMKTAYGSYVDVTRYLQLIFN 296
            .:...||..::|:.:|..:|:....:..   :||..........:.|.|...: :.|.::|.:.:
Frog   283 DDSLVQEEMTRVMDLETDIARATAPSEERNDVTLLYNKMTLLEFQQKFALDDF-NWTSFIQGVMS 346

  Fly   297 D-NLYMD------LYETPEDYMSNLVDVIRETPKLQLANYTMWKALEALDIARVP---------- 344
            . |:.:.      :|..|  |:..|.:::.......|.||.:|:.:    |.||.
Frog   347 SVNIQLQAEEEVVVYGAP--YLHQLKNILSNYSASTLQNYVVWRMV----IDRVSSLSRRYKDAR 405

  Fly   345 ASQRADIWCVQLAQ-------QFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFRED-LQASE 401
            ||.|..::...|.:       .:....:|:.....|.......|.:...||:....||. ::..:
Frog   406 ASYRKALYGTTLEEARWRECVSYVNSNMENAVGAMYVKETFAGESKRMISDLINKVREAFIETLD 470

  Fly   402 RLLWLTLETRQKAITKLEALKLHFRTHD------DNKLIRQMHGLILNMDRFYPNLVSVLQWKTQ 460
            .|.|:...::.||..|..::|......|      ::||.::...|..:..:::.|::.:|....|
Frog   471 ELQWMDETSKDKAREKALSIKEQIGYPDYILEDQNDKLDQETAALNFSEYQYFENILEILNSGAQ 535

  Fly   461 RGLAKLMTEPVAED-----EVHKLPHYEIQKNRIQVPITFLQARFFWDPAYPNGLKYATLGVLLA 520
            :.|.|| .|||.:|     .......|...:|:|..|...||..|| :...|..|.:..:|:::.
Frog   536 KSLKKL-REPVDQDAWIIGAAVADAFYSPNRNQIVFPAGILQPPFF-NKHQPQALNFGGIGMVIG 598

  Fly   521 RQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFV-EYK-GKPVQDKDLLRRI 583
            .::.||||..||.:|..|...:||.:.|...:..:::|...||..:. |.. |:.|.....|...
Frog   599 HEITHGFDDNGRNFDKDGNMFDWWSNFSAMHFKDQSRCMVYQYGNYTWELAGGQNVSGIITLGEN 663

  Fly   584 VADNGALDIAYRAYQQWLKNAAETPVIYQRERLPLLDHDHNQIFYLGYAQLYCTDY-PE----TV 643
            :||||.:..||:||.:|::...:.|      :||.||..:.|:|:|.:||::|..| ||    ::
Frog   664 IADNGGVRQAYKAYLKWVERHGKEP------KLPGLDLTYKQLFFLNFAQVWCGSYRPEYARHSI 722

  Fly   644 ERFDELPEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686
            :.....|.:.||..:|.|.:.||..:.|.:..|::...||.::
Frog   723 KTDVHSPFKYRVMGSLQNFEAFAEEFNCKKGTKMHPVEKCRVW 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl15	NP_651098.2	M13	57..684	CDD:189000	170/702 (24%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	168/695 (24%)
mmel1	XP_012821551.1	M13	95..763	CDD:341056	170/705 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110