Protein Alignment Nepl14 and ECE2

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 719
• Identity: 152/719 - (21%)
• Similarity: 274/719 - (38%)
• Gaps: 141/719 - (19%)

  Fly    56 VNKSIDPCVDFYAYACGNW---------KSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQA 111
            :::.:.||.|||.::||.|         :|.......|..|....|..|:|.......|...::.
Human   156 LDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 220

  Fly   112 KELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDIL 176
            :..:.||:..:..:....|. |.:.|.:.||:...  ..|    ...|::.||..:...|.....
Human   221 QRFYLSCLQVERIEELGAQP-LRDLIEKIGGWNIT--GPW----DQDNFMEVLKAVAGTYRATPF 278

  Fly   177 IGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDES 241
            ..:.:..:..:.|.|.:.:.:....:|:          ||...    :|.|:|
Human   279 FTVYISADSKSSNSNVIQVDQSGLFLPS----------RDYYL----NRTANE------------ 317

  Fly   242 ARLAADILSFEHE---LCGGMKGGSFESWD--AEEQLYLANYT-----RK------------TLR 284
             ::....|.:..|   |.||....:.|...  .|.::.|||.|     |:            .|:
Human   318 -KVLTAYLDYMEELGMLLGGRPTSTREQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ 381

  Fly   285 EFSNSIE-LDLDSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFP 348
            ..:.|:: |:..|::.:.......:||.:...:|.:|:...::....|::.||:::..|......
Human   382 ALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSS 446

  Fly   349 LDDRPQL------------------RKRECLERTKELLPTALGELYARQFGTEDGRIDLDNLYDT 395
            ||.|.:.                  |.:.|:..|.:.|..|||.|:.:.......:...:.:...
Human   447 LDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISE 511

  Fly   396 LKTALRQSLG-AEWLVEGTQRVGQEKLRNL--KLQMPTYERPVILK----------LQLERGNYW 447
            ::||..::|| ..|:.|.|::..:||...:  .:..|.:    ||:          .::...:::
Human   512 IRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDF----ILEPKELDDVYDGYEISEDSFF 572

  Fly   448 QNLRQLLG----VVQSQRNNRLFEEFLPAPTDPVEAYEARVRLRPVQRRLDMGLALLQPPAYDPR 508
            ||:..|..    |:..|.......:........|.||     ..|.:..:.....:||.|.|...
Human   573 QNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAY-----YLPTKNEIVFPAGILQAPFYARN 632

  Fly   509 YGHAIRYATLGVQLAQQLVMAFDD---PHWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYL-- 568
            :..|:.:..:||.:..:|..||||   .:...|.| |..|..::...:...:.|...|.:.|.
Human   633 HPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNL-RPWWQNESLAAFRNHTACMEEQYNQYQVN 696

  Fly   569 --RPNVSATT-QLITDSAAINVAFRAYLTWL---GFQEPNNDFTKLTKETLPDLNYSNTALFFLA 627
              |.|...|. :.|.|:..:..|:.||..||   |           .::.||.:..:|..|||:.
Human   697 GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHG-----------EEQQLPAVGLTNHQLFFVG 750

  Fly   628 YAQEHCSLEEARPRDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASK 692
            :||..||:     |..:.:.||.:   ...|:..|..|.|.|.||.:|...|.||:||||||...
Human   751 FAQVWCSV-----RTPESSHEGLV---TDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQL 807

  Fly   693 CIIY 696
            |.::
Human   808 CEVW 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	151/710 (21%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	151/711 (21%)