Protein Alignment Nepl14 and Ece1

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_006239337.1
• Gene: Ece1 / 94204
• RGDID: 620293
• Length: 769
• Species: Rattus norvegicus
• Alignment Length: 710
• Identity: 169/710 - (23%)
• Similarity: 292/710 - (41%)
• Gaps: 123/710 - (17%)

  Fly    56 VNKSIDPCVDFYAYACGNW-KSTLTPQ--------QQLQQQTDRELLLLVEEAVRREDSVIVRQA 111
            ::.::|||.||::||||.| |:...|.        ..|.:.....:..|:|.:. ...|...::|
  Rat   114 MDPTVDPCQDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST-ASASEAEKKA 177

  Fly   112 KELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDIL 176
            :..:::|:: :....:.:...|.|.|.:.||:...  ..||..    |:...|..:...|.....
  Rat   178 QVYYRACMN-ETRIEELRAKPLMELIEKLGGWNIT--GPWAKD----NFQDTLQVVTAHYRTSPF 235

  Fly   177 IGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDES 241
            ..:.|..:..|.|.|.:.:.:....:|:.....|:::....:...|.:.|  :|...|..|.::|
  Rat   236 FSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV--QLGKLLGGGDEDS 298

  Fly   242 AR-LAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFGQD 305
            .| ....||.||..|......   :....:|:|.....|...|:..:.:|  :...::.|.|
  Rat   299 IRPQMQQILDFETALANITIP---QEKRRDEELIYHKVTAAELQTLAPAI--NWLPFLNAIF--- 355

  Fly   306 IY-------KPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRPQ--------- 354
             |       :|:.:...||.||:...:::.:..|:.||:|:..|...:..||.|.|
  Rat   356 -YPVEINESEPIVVYDKEYLRQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEV 419

  Fly   355 --LRKRECLER-------TKELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSLGA-EWL 409
              ..|:.||.|       |:..|..|||.::.:....||.:.....:...:|.|..:||.. :|:
  Rat   420 MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWM 484

  Fly   410 VEGTQRVGQEKLRNLKLQMPTYERPVILKLQLER---------GNYWQNLRQLLGVVQSQRNNRL 465
            .|.|:|..:||...: ..|..|...::...:|::         ..|::|..            |.
  Rat   485 DEDTRRSAKEKADAI-YNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM------------RF 536

  Fly   466 F--------EEFLPAP-------TDP-VEAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIR 514
            |        ::...||       |.| |.||.:     |.:..:.....:||.|.|.....:|:.
  Rat   537 FNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYS-----PTKNEIVFPAGILQAPFYTRSSPNALN 596

  Fly   515 YATLGVQLAQQLVMAFDD---PHWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYL---RPNVS 573
            :..:||.:..:|..||||   .:...|.| |..|...:...:..::.|..:|.:||.   .|...
  Rat   597 FGGIGVVVGHELTHAFDDQGREYDKDGNL-RPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNG 660

  Fly   574 ATT--QLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLE 636
            ..|  :.|.|:..:..|:|||..|:   :.|.     .::.||.|..::..||||.:||..||:
  Rat   661 RHTLGENIADNGGLKAAYRAYQNWV---KKNG-----AEQILPTLGLTSNQLFFLGFAQVWCSV- 716

  Fly   637 EARPRDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696
                |..:.:.||.:   ...|:.:|..|.|.|.||.||:..||||:||||||..||.::
  Rat   717 ----RTPESSHEGLI---TDPHSPSRFRVIGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	167/701 (24%)
Ece1	XP_006239337.1	M13	118..767	CDD:341056	168/702 (24%)