Protein Alignment Nepl14 and PHEX

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 735
• Identity: 175/735 - (23%)
• Similarity: 292/735 - (39%)
• Gaps: 162/735 - (22%)

  Fly    54 SHVNKSIDPCVDFYAYACGNW-KSTLTPQQQ--------LQQQTDRELLLLVEEAV-RREDSVIV 108
            |.||.|:|||.:|:.:||..| .:...|:..        |:...|.:|..|:|::: ||.|:..:
Human    68 SKVNLSVDPCDNFFRFACDGWISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAI 132

  Fly   109 RQAKELFKSCVSAQAHQSQQQQ---HFL--SEF----INQNGGFPAVPGSQWAVHHHDYNWLSVL 164
            ::||.|:.||::.:|.:....:   |.|  |.|    :..|.|    |...|:  ...::.|..|
Human   133 QKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIG----PEGVWS--ERKFSLLQTL 191

  Fly   165 GGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASE 229
            ...|.:|...:.|.|.|..:....||:.|.|.:.:      |....|.|..|:..|...:|.|
Human   192 ATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQAT------LSLAVREDYLDNSTEAKSYRDA-- 248

  Fly   230 LKSWLALGHDESARLAADILSFEHELCGGMKGGSFESWDAEEQLYLAN------YTRKTLREFSN 288
            |..::.   |.:..|.|:....||::...::   .|...||..:...|      |.:..:.|.|.
Human   249 LYKFMV---DTAVLLGANSSRAEHDMKSVLR---LEIKIAEIMIPHENRTSEAMYNKMNISELSA 307

  Fly   289 SI-ELDLDSYVRASFGQDIY---------KPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVS 343
            .| :.|...|::......:|         :.|.:..|:||:.|.|.:.:.....:|||:::|.|.
Human   308 MIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVY 372

  Fly   344 ALNFPLDDRPQLRKRE-----------------CLERTKELLPTALGELYARQFGTEDGRIDLDN 391
            :....|..|.|.|..|                 |:...:..||..:|:::...:..||.:..::.
Human   373 SRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEE 437

  Fly   392 LYDTLKTALRQSLGA--EWLVEGTQRVGQEKLRNL--KLQMP------TYERPVILKLQLERGNY 446
            |.:.::.|....|..  ||:..||:|..:||.|.:  |:..|      |:....:..::....:|
Human   438 LVEGVRWAFIDMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADY 502

  Fly   447 WQNLRQLLGVVQSQR---NNRLF--------EEFLPAPTDPVEAYEARVRLRPVQRRLDMGLALL 500
            :.|      |:|:::   .:..|        .|:...||.....|.|...    |.|...| .|.
Human   503 FGN------VLQTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTN----QIRFPAG-ELQ 556

  Fly   501 QPPAYDPRYGHAIRYATLGVQLAQQLVMAFD------------DPHWSVGLLERDNWDGQTAWQY 553
            :|..:...|..::.|..:||.:..:....||            ||.||.          ::..::
Human   557 KPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWST----------ESEEKF 611

  Fly   554 HIRSNCFARQVDNYLRP----NVSATTQL---ITDSAAINVAFRAYLTWL-----GFQEPNNDFT 606
            ..::.|...|..||...    ||.....|   |.|:..:..|||||..|:     |.:||
Human   612 KEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEP----- 671

  Fly   607 KLTKETLPDLNYSNTALFFLAYAQEHCSL---EEARPRDEQGTPEGYLYSARQNHTWTRLLVNGP 668
                 .||.:.::|..||||:||...|:.   |.||.:.:.|.           |:..:..|||.
Human   672 -----LLPGITFTNNQLFFLSYAHVRCNSYRPEAAREQVQIGA-----------HSPPQFRVNGA 720

  Fly   669 LRNSVEFASEFRCPIGSPMN 688
            :.|..||...|.||..|.||
Human   721 ISNFEEFQKAFNCPPNSTMN 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	171/729 (23%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	169/727 (23%)