Protein Alignment Nepl14 and KEL

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 766
• Identity: 180/766 - (23%)
• Similarity: 296/766 - (38%)
• Gaps: 182/766 - (23%)

  Fly     4 PCWTTVFLWLLWLPHLQQNALVSGEDLPPPFQRIYQSEQTVRRSKAQDMGSHVNKSIDPCVDFYA 68
            ||.|:|.|      .|:.:.|.||                             |.|:.||.||::
Human    88 PCETSVCL------DLRDHYLASG-----------------------------NTSVAPCTDFFS 117

  Fly    69 YACGNWKSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFKSCVSAQAHQSQQQQHFL 133
            :|||..|.|....|:|..:....|..::|............:|.:.:.||:...|.::..... |
Human   118 FACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGP-L 181

  Fly   134 SEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEP 198
            .:.|.:.||: .:.| :|.    ..|:...|..|..:||........:|.:..:.:...:.:.:|
Human   182 RQVIEELGGW-RISG-KWT----SLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQP 240

  Fly   199 STLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWL-----ALGHD-----ESARLAADILS--- 250
            ...:|.      :.|....||.    ::..|..::|     .||.|     |.:.|:..|.|
Human   241 EFDVPL------KQDQEQKIYA----QIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLF 295

  Fly   251 -FEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFGQDIYKP---VY 311
             |...|         |...|:.:|: ...|...|:|.:.:|  |..|.::|:|......|   :.
Human   296 QFLRPL---------EQRRAQGKLF-QMVTIDQLKEMAPAI--DWLSCLQATFTPMSLSPSQSLV 348

  Fly   312 MAAPEYFRQLKRTVSAHNI---SLVANYIMYRAVSALNFPLDDRPQLRKR--------------- 358
            :...||.:.:.:.|....:   ..:.::::...|..|:..||.:.|..:|
Human   349 VHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPM 413

  Fly   359 -------ECLERTKELLPTALGELYARQ-FG--TEDGRIDL-DNLYDTLKTALRQSLGAEWLVEG 412
                   :|:|.|.......|..|:.|: ||  |....:.| ..:.|.|.|.||   ...|:.|.
Human   414 PARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLR---NLPWMNEE 475

  Fly   413 TQRVGQEKLRNLKLQMPTYERPVILKLQLERGNYWQN--------LRQLLGVVQSQRNNRLFEEF 469
            ||.:.|:|:..|:::|...|  ..||.:|.|..|  |        |:.:|..|:|.| .|:.:.|
Human   476 TQNMAQDKVAQLQVEMGASE--WALKPELARQEY--NDIQLGSSFLQSVLSCVRSLR-ARIVQSF 535

  Fly   470 LP---------APTDPVEAYEA---RVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYATLGVQL 522
            |.         :|.| |.||.:   .|.:.|.        .|||||.:.|.|..|:.:...|..:
Human   536 LQPHPQHRWKVSPWD-VNAYYSVSDHVVVFPA--------GLLQPPFFHPGYPRAVNFGAAGSIM 591

  Fly   523 AQQLVMAFDDPHWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYLRPNVSATTQLIT------D 581
            |.:|:..|.......|.|..||...|.|   |:   |..|....:..|:.::....:|      |
Human   592 AHELLHIFYQLLLPGGCLACDNHALQEA---HL---CLKRHYAAFPLPSRTSFNDSLTFLENAAD 650

  Fly   582 SAAINVAFRAYLTWLGFQEPNNDFTKLTKET-LPDLNYSNTALFFLAYAQEHCSLEEARPRDEQG 645
            ...:.:|.:||         :....:...|| ||.|:.|...:||.:|||..|  .:..|:|...
Human   651 VGGLAIALQAY---------SKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMC--RKPSPQDSHD 704

  Fly   646 TPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696
            |           |:...|.|:|||.::..||..|||..|:.:||:|:|.::
Human   705 T-----------HSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	168/705 (24%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	168/706 (24%)