Protein Alignment Nepl14 and nep-25

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_495164.2
• Gene: nep-25 / 191543
• WormBaseID: WBGene00022874
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 674
• Identity: 113/674 - (16%)
• Similarity: 211/674 - (31%)
• Gaps: 241/674 - (35%)

  Fly    55 HVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFKSCV 119
            |.:.|:||||||||:.| .||
 Worm    35 HADFSVDPCVDFYAHVC-PWK-------------------------------------------- 54

  Fly   120 SAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGLRVGYN 184
                    .:::|:.:......|..|    ::...|..::...
 Worm    55 --------VERYFMEDLSKLKAGMVA----KYRKKHPKFDKFK---------------------- 85

  Fly   185 YGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHDESARLAADIL 249
                .|::..::|....:..|   :.:|:.:.|  :|       .|.|:.....|.......|.:
 Worm    86 ----GEDAFAIAEALKQLNIE---QLKSECKPS--KP-------RLSSFFISAQDNRTIENVDEV 134

  Fly   250 SFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFGQDIYKPVYMAA 314
            .|.          .||::..||:..:.......:.:::.:..: |.|.|.......:.:.:.:.|
 Worm   135 LFP----------GFENYPCEEKAAIIIKEVGEIEDYTTTRSV-LVSAVNGFITSKLVEKLDVKA 188

  Fly   315 PEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRPQLRKRECLERTKELLPTALGELYARQ 379
            .:.|.:.|..:|...|.                    .|..:..:.:|:..|    ||..:..|.
 Worm   189 RKLFNKFKSVISKEIIK--------------------TPWAKNYKAIEQYVE----ALSNITFRT 229

  Fly   380 FGTEDGRIDLDNLYDTLKTALRQSLGAEWLVEGTQRVGQEKLRNLKLQMPTYERPVILKLQLERG 444
            |.  |.||       |:|.::.       |.|.|::..::|| ::....||.|  ::.|
 Worm   230 FA--DVRI-------TVKKSME-------LYESTEKDCRKKL-DVAFSQPTAE--LVCK------ 269

  Fly   445 NYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDPVEAYEARVRLRPVQRRLD-------MG---LAL 499
                      ||.     .|..||.|..|.:.:...:....|:.|.:..:       :|   |.|
 Worm   270 ----------GVA-----TRKAEELLDEPIEDIFPQDQAGILKDVWQMFNSFDNSVYIGNEFLLL 319

  Fly   500 LQPPAYDPRYGHAIRYATLGVQLAQQLV--MAFDDPHWSVGLLERDNWDGQTAWQYHIRSNCFAR 562
            |....:...||      ::|..:..:::  :.|||          ::.|...:..:...::|...
 Worm   320 LNTDYFSDLYG------SIGFSMIHEIMHTLVFDD----------NDLDKPLSKLWTKNADCVKD 368

  Fly   563 QV------------DNYLRPNVSATTQL---ITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKET 612
            |.            .:.::|..:.|...   ..|.||..:|:|.|         .|.:.:  |..
 Worm   369 QALKTCETFPTVTEMHNMKPACNTTVTFEEDAADLAAYRIAWRIY---------ENSYAR--KTV 422

  Fly   613 LPDLNY---SNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVE 674
            :|  ||   ....|||...|...|        ::.|.......:...::.:.|  ||..:....:
 Worm   423 VP--NYEALDKKQLFFYGAAVFFC--------NQDGMSRVPFQNLAHSNNYQR--VNSLMSQMKQ 475

  Fly   675 FASEFRCPIGSPM--NPASKCIIY 696
            |:..|:|.....|  |.|..|.:|
 Worm   476 FSDAFKCKPTDKMITNRAKHCELY 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	109/664 (16%)
nep-25	NP_495164.2	Peptidase_M13	308..496	CDD:279739	41/226 (18%)