Protein Alignment Nepl14 and ECE1

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_011539174.1
• Gene: ECE1 / 1889
• HGNCID: 3146
• Length: 778
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 169/706 - (23%)
• Similarity: 287/706 - (40%)
• Gaps: 111/706 - (15%)

  Fly    54 SHVNKSIDPCVDFYAYACGNW-KSTLTPQ--------QQLQQQTDRELLLLVEEAVRREDSVIVR 109
            |.::.::|||.||::||||.| |:...|.        ..|.:.....:..|:|.:. ...|...|
Human   121 SSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENST-ASVSEAER 184

  Fly   110 QAKELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMD 174
            :|:..:::|:: :....:.:...|.|.|.:.||:...  ..||..    |:...|..:...|...
Human   185 KAQVYYRACMN-ETRIEELRAKPLMELIERLGGWNIT--GPWAKD----NFQDTLQVVTAHYRTS 242

  Fly   175 ILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGHD 239
            ....:.|..:..|.|.|.:.:.:....:|:.....|:::....:...|.:.|  :|...|..|.:
Human   243 PFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMV--QLGKLLGGGDE 305

  Fly   240 ESAR-LAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLR---------EFSNSIELDL 294
            |:.| ....||.||..|......   :....:|:|.....|...|:         .|.|:|...:
Human   306 EAIRPQMQQILDFETALANITIP---QEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPV 367

  Fly   295 DSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRPQ----- 354
            :  :..|      :|:.:...||..|:...::..:..|:.||:::..|...:..||.|.|
Human   368 E--INES------EPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 424

  Fly   355 ------LRKRECLER-------TKELLPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSLGA 406
                  ..|:.||.|       |:..|..|||.::.:....||.:.....:...:|.|..:||..
Human   425 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLST 489

  Fly   407 -EWLVEGTQRVGQEKLRNLKLQMPTYERPVILKLQLER---------GNYWQNLRQLLGVVQSQR 461
             :|:.|.|::..:||...: ..|..|...::...:|::         ..|::|..:....  |.|
Human   490 LKWMDEETRKSAKEKADAI-YNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF--SWR 551

  Fly   462 NNRLFEEFLPAP-------TDP-VEAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYATL 518
            ...  ::...||       |.| |.||.:     |.:..:.....:||.|.|......|:.:..:
Human   552 VTA--DQLRKAPNRDQWSMTPPMVNAYYS-----PTKNEIVFPAGILQAPFYTRSSPKALNFGGI 609

  Fly   519 GVQLAQQLVMAFDD---PHWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYL---RPNVSATT- 576
            ||.:..:|..||||   .:...|.| |..|...:...:..::.|...|..||.   .|.....|
Human   610 GVVVGHELTHAFDDQGREYDKDGNL-RPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTL 673

  Fly   577 -QLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEARP 640
             :.|.|:..:..|:|||..|:   :.|.     .:.:||.|..:|..||||.:||..||:
Human   674 GENIADNGGLKAAYRAYQNWV---KKNG-----AEHSLPTLGLTNNQLFFLGFAQVWCSV----- 725

  Fly   641 RDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696
            |..:.:.||.:   ...|:.:|..|.|.|.||.||:..||||.||||||..||.::
Human   726 RTPESSHEGLI---TDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	166/695 (24%)
ECE1	XP_011539174.1	M13	127..776	CDD:341056	167/696 (24%)