Protein Alignment Nepl14 and nep-18

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 736
• Identity: 167/736 - (22%)
• Similarity: 266/736 - (36%)
• Gaps: 168/736 - (22%)

  Fly    54 SHVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKEL---F 115
            ::.|.|:|||.||:.:.||.:...:...........::||..|....|:.:....:..::|   .
 Worm    41 NYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLLYQVFAIARKTNKFNSKPNEQLRIFT 105

  Fly   116 KSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNW------LSVLGGLRLRYGMD 174
            |||:..:.......|...:: |.:.||||.:          |.||      ||           |
 Worm   106 KSCLDRKEMDEDTFQDLRND-IEERGGFPMI----------DPNWNEEKFDLS-----------D 148

  Fly   175 ILIGLRVGYNYGNVNENSL-YLS-EPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSW---L 234
            :|.      .|.::|.|.: :|| ||...|      .....:......|..|.|    .:|   :
 Worm   149 MLA------KYLSINRNRMGFLSVEPYAAI------EGNKSVNRLYVSPGPHWV----YNWAMGI 197

  Fly   235 ALGHDESARLAADILSFEH-ELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYV 298
            ::..|..|.:...:|..|: ||...:....|    ||.....||::  ||.::.| :.||.|:..
 Worm   198 SIYKDSVAFMLRRLLKLENRELNETIYDKEF----AELVQLEANFS--TLADYRN-LALDNDNMS 255

  Fly   299 RASFGQDIYKPV------------------------------YMAAPEYF----RQLKRTVSAHN 329
            ::....|:.|.:                              ...|.|||    |:|.|..:...
 Worm   256 KSRNLTDLVKMIPEIDWIKILKALARHGTSEEDEEKLLERVTVHGAGEYFFGENRELARIATETP 320

  Fly   330 ISLVANYIMYRAV--SALNFPLDDRPQLRK--------RECLERTKELLPTALGELY--ARQFGT 382
            .|.:|||::.|.:  .||.|...|:|:..|        ..|..:.....|.....::  :.||..
 Worm   321 KSALANYLVVRQLIDVALYFYDKDQPRQNKFYNHVDQQSFCATQVASFFPMPSMNVFIESSQFKI 385

  Fly   383 EDGRIDLDNLYDTLKTALRQSLGAEWLVEGTQRVGQEKLRNLK-------LQMPTYERPVILKLQ 440
            |:.:: ::.::..:|....|.......:|  ..:.:..:|.|.       |...|..:|::.|:.
 Worm   386 ENLKV-IEEMFVKIKAEYEQIFTENEYLE--LEIREFLIRKLNAIDGKFGLDQYTEGKPLLEKMY 447

  Fly   441 -----LERGNYWQNLRQLLGVVQSQRNNRLFEEFL-PAPTDPV--EAYEARVRLRPVQRRLDMGL 497
                 |:..:.||...::    ....:.:|.|..: ..|.|||  :.:......:|......:.|
 Worm   448 ETLNFLDTDSPWQVYMKM----WRHWSEQLVEHIVHDTPLDPVNLKMFGTHAAYQPYPNHFYINL 508

  Fly   498 ALLQPPAYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGLLERDN--WDGQT---AWQYHIRS 557
            ..|..|..|..:.....|..||..:..::..|||..|..:....|..  |..:|   ..:|.:|.
 Worm   509 PYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQQYWFTETNSSNTEYELRE 573

  Fly   558 NCFARQVDNYLRP-------NVSATTQLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKE---T 612
            .|...|...|..|       ......::..|...|..|||.             |.|:.||   .
 Worm   574 KCLRDQYSAYKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRV-------------FEKVKKEDRFR 625

  Fly   613 LPDLNYSNTALFFLAYAQEHCSLEEAR--PRDEQGTPEGYLYSARQNHTWTRLLVNGPLRNSVEF 675
            ||.|..|...|||..||...|.:....  ||:         ..||| |...|..|||.::|..||
 Worm   626 LPGLEMSEEQLFFYNYAFRQCDVYNPNKLPRN---------MLARQ-HPTNRYRVNGVIQNIPEF 680

  Fly   676 ASEFRCPIGSPMNPASKCIIY 696
            |..|.||..|||||..||.:|
 Worm   681 AEAFNCPKNSPMNPEMKCKLY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	162/725 (22%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	163/726 (22%)