Protein Alignment Nepl14 and nep-8

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001309548.1
• Gene: nep-8 / 184631
• WormBaseID: WBGene00017553
• Length: 686
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 137/726 - (18%)
• Similarity: 264/726 - (36%)
• Gaps: 176/726 - (24%)

  Fly     1 MSDPCWTTVFLWLLWL------PHLQ------QNALVSGEDLPPPFQRIYQSEQTVRRSKAQDMG 53
            :|.| |..|.|.||.:      .|::      ...|..|.|:..  :.:..|.:.:..|  .::.
 Worm    10 LSRP-WVAVNLLLLIVFLAMVTVHIKVEPVNLDELLSIGNDVDS--KNLCDSPECITLS--HELL 69

  Fly    54 SHVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTD------RELLLLVEEAVRREDSVIVRQAK 112
            ::.:.|:||||||:.::||.:......:.:||::..      ||.|..::.:..:.::::    |
 Worm    70 NYQDPSVDPCVDFFQHSCGRFHEQSVSESRLQKKKHILRKQIREFLHKIQNSTSKSENLM----K 130

  Fly   113 ELFKSCVSAQAHQ------SQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNW----------- 160
            .:|..|.:::...      |:...|.:...|.:.|.:|.:          |.||
 Worm   131 LVFDKCEASKKTSNDNYKISRDAIHDVFNDIKKIGAWPLL----------DKNWDGSKFDLNEML 185

  Fly   161 --LSVLGGLRL-RYGMDILI-----GLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDS 217
              |..||...| .:.:|..|     .:|:....|::..||..:|..|.::.......:..:|...
 Worm   186 SNLVKLGATNLGLFQLDFRILTEGKFVRIAPTLGSIVHNSTMISMISEILEANGVQPDSEEISKE 250

  Fly   218 I--YEPLEHRVASELKSWLALGHDESARLAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTR 280
            .  |..|:.::|.         :..|.:|:..:        .|::..:|.|.
 Worm   251 FEEYSSLQMKLAK---------YQSSGKLSISL--------PGVRSINFSSL------------- 285

  Fly   281 KTLREFSNSIELDLDSYVRASFGQDIYKPVYMAAPEYFR-----QLKRTVSAHNISLVANYIMYR 340
                    ..|:...|.|...||:  .:.|....|.:|:     .|...:.:.:...:||::::.
 Worm   286 --------ITEMIHPSRVSKIFGK--IRVVTSEHPLFFKSNETESLDTIIESTSNKTLANFLIFN 340

  Fly   341 AV-SALNFPLDDRPQLRKRECLERTKELLPTALGELYARQFGTEDGRIDLDNLYDTL-KTALRQS 403
            .: |:.|.    ....|:..|.:..:...|.|...::.|.|..:..|..:..|.:.| |..|...
 Worm   341 YIQSSYNI----MKGARRGNCEDDVRREFPRASLRVFMRNFVDKGNRDGVKKLTEELKKNTLEMI 401

  Fly   404 LGAEWLVEGTQRVGQEKLRNLKLQM---PTYERPVILKLQLER------GNYWQNLRQLLGVVQS 459
            ...|.|....:....:|:..:|:.:   ..::.|..|..:.|.      .:|::..::|
 Worm   402 QDTENLAPPVKESMLKKVEAIKVTIGYPDHFDPPGTLDKEFENFDLDSTDSYYRIFQKL------ 460

  Fly   460 QRNNRLFE----EFL--PAPTDPV-EAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYAT 517
               |||..    ||:  ..|..|: |..:.....:..:..|.:....|..|.:|..|...:....
 Worm   461 ---NRLRSEQQMEFIAGETPISPIKEVLKVNANYKRSKNALTVFAPFLDDPFFDITYPDYVNLFF 522

  Fly   518 LGVQLAQQLVMAFDDPHWSVGLLERDN---WDG---QTAWQYHIRSNCFARQVDNYLRP------ 570
            .|..:|.::..:.|    :.||...:|   .||   :...:|..:..|...|.|||..|
 Worm   523 SGFLIAHEIGHSVD----ANGLGYDENGKPMDGIRLEHVTEYGKQGQCLVDQYDNYDDPVYGKKM 583

  Fly   571 -NVSATTQLITDSAAINVAFRAY--------LTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFL 626
             ...:..::|.|.....|.:|||        |:.:|.::.|.|          .|.:...:|.|
 Worm   584 NGTHSINEIIADWVGHEVTWRAYKKMDTSKMLSLIGLKDINMD----------QLYFRVQSLLF- 637

  Fly   627 AYAQEHCSLEE 637
            ...::..||||
 Worm   638 CRERDTISLEE 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	123/655 (19%)
nep-8	NP_001309548.1	M13	76..664	CDD:341056	123/655 (19%)