Protein Alignment Nepl14 and nep-22

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 808
• Identity: 154/808 - (19%)
• Similarity: 288/808 - (35%)
• Gaps: 207/808 - (25%)

  Fly    33 PFQRIYQSEQTVRRSKAQDMGSH-----VNKSIDPCVDFYAYACGNW----------KSTLTPQQ 82
            |..::..:..||..|.:....::     ::.::|||.||||:.|..:          :|.|....
 Worm    51 PAPQVNSTPGTVNTSPSYTQAANYLLNGLDDTVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYD 115

  Fly    83 QLQQQTDRELLLLVE--EAVRREDSVIVRQAKELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPA 145
            |.|.....|::..:.  :......|...|..|..|::|.:..|..:.:.....:|..:..||.|.
 Worm   116 QAQVDVYSEIVAALSKIDVTSTTTSKTERITKAAFETCKNNLASPADKTAVVYAEITSLFGGVPF 180

  Fly   146 VPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEPSTLI-------P 203
            .  .:....:.|| |: |.|.:..::.:..|.......:|.:..:|:||...|...:       |
 Worm   181 F--GEPLKTNVDY-WM-VAGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSLARDFYVKP 241

  Fly   204 TELCTRNR--SDIRDSIYEPLEHRVASELKSWLALGHDESARLAADILSFEHELCGGMKGGSFES 266
            ..:...|:  ||:.|     |....|:..|.  .:|.|.....|.::::||.::       :..|
 Worm   242 QYIAEVNQRVSDVND-----LLTAFANAAKK--NVGADALLAAAQEVVNFEVQI-------AMAS 292

  Fly   267 WDAE-----EQLY----LANYT--------RKTLREFSNSIELDLDSYVRASFGQDIYKPVYMAA 314
            |..:     :|.|    :|:.|        :..|.:..:.:..|.|   :|::.      :.:..
 Worm   293 WPDDLLRNYQQQYNPYNIASATTAYRAINWKSYLGQLFHGVASDAD---QANYN------IVVTE 348

  Fly   315 PEYFRQLKRTV--SAHNISLVANYIMYRAV------------------SALNFPLDDR---PQLR 356
            |.||..|....  ...|.::||||::.:.:                  :.:::.|.:.   .::.
 Worm   349 PSYFAWLNSVFDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIG 413

  Fly   357 KRE------------CLERTKELLPTALGELYAR--------QFGTED----------GRIDLDN 391
            |||            |::.....:|...|.:|.:        |...:|          |.||..|
 Worm   414 KREYRMADLDGISEGCMDLLTAYMPYGTGYVYVKSKSERNKVQADVKDQTTLIINNFQGMIDSLN 478

  Fly   392 LYDTL--------KTALRQSLGAEWLVEG-------TQRVGQEKLRNLKL----QMPTYERPVIL 437
            ..||.        ..:|.::.|....:.|       .....|:....:.|    :...|....:|
 Worm   479 WMDTFSKNRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAYNQDYASIIDLYTKDKNDIYGIFAVL 543

  Fly   438 KLQLERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDPVEAYEARVRLRPVQRRLDMGLALLQP 502
            |..:|...::    :::|....:.|      ||.:|. .|.|:     .:|.:..:....|...|
 Worm   544 KKGMEVREFF----RIMGEPADRTN------FLQSPA-MVNAW-----YQPERNSITFPYAAWNP 592

  Fly   503 PAYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGL---LERDNWDGQTAWQ-------YHIRS 557
            |.|:..|..|..:|..|.....:|...:||.....|.   |...:|: :..|.       :...:
 Worm   593 PYYNLNYPQAYNFAGQGGTGGHELTHGYDDEGVQFGFNGELTDCSWN-KCGWMDTNSSSGFIDMA 656

  Fly   558 NCFARQVDNYLRP----NV----SATTQ--LITDSAAINVAFRAYLTWL-----GFQEPNNDFTK 607
            .|...|......|    |:    .||||  .|.|......|:|:|..::     |.:|
 Worm   657 QCVVTQFSTQCCPEKTGNIHCANGATTQGENIADLGGQQAAYRSYRQYVATTRKGVEE------- 714

  Fly   608 LTKETLPDL-NYSNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQN-HTWTRLLVNGPLR 670
               :.||.| ||:...:|::.|....|..:         :....::....| |:..:...|..::
 Worm   715 ---DRLPGLENYTPNQIFWITYGYSWCMKQ---------SDANLVHQLLTNPHSPAQCRTNQVMQ 767

  Fly   671 NSVEFASEFRCPIGSPM--NPASKCIIY 696
            :..||..:|.|..||||  .|:.:|.::
 Worm   768 DIPEFGKDFGCVRGSPMYPEPSGRCKVW 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	149/771 (19%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	149/772 (19%)