Protein Alignment Nepl14 and nep-16

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001023203.2
• Gene: nep-16 / 177541
• WormBaseID: WBGene00018472
• Length: 868
• Species: Caenorhabditis elegans
• Alignment Length: 749
• Identity: 158/749 - (21%)
• Similarity: 260/749 - (34%)
• Gaps: 232/749 - (30%)

  Fly    52 MGSHVNKSIDPCVDFYAYACGNWKSTLTPQQQ--LQQQTDRELLLLVEEAVRREDSVIV----RQ 110
            :.|.::..|:||.:||.|:|..:.|....:|.  |.|..|..|..:.......|||.::    |.
 Worm   246 LSSCIDDEIEPCENFYRYSCQRYHSQTADKQMSFLSQLKDESLRRMHSLLSSEEDSRLLPKSARL 310

  Fly   111 AKELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHH--DYNWLSVLGGL------ 167
            ::.|:.:|::|....|......|: ||.   .||..|..:...:.|  .|:|....|.|
 Worm   311 SRSLYSACMNAVLRSSNAPTDLLT-FIR---NFPCGPLLRDCQNFHADSYSWERHAGMLDWYAGR 371

  Fly   168 --RLRYGMDI-------------------LIGLRVGYNYGNVNENSLYLSEPSTLIPTE------ 205
              .:.|..|:                   ::||        :..:.:.|:.||   |||
 Worm   372 YNLIVYDRDVHPQDRSKIILQIKPPDLTPIVGL--------IERDLIDLARPS---PTEFEPLLQ 425

  Fly   206 LCTRNR---SDIRDSIY-EPLEHRVASELKSWLALGHDESARLAADILSFEHELCGGMKGGSF-- 264
            |..|..   :..|||:. :|.:  |.|:|        ||.|||..|:.....:........::
 Worm   426 LSLRQNLLSAFARDSLLRDPRD--VQSQL--------DEVARLMVDLYISARQSASLTPNTTYMT 480

  Fly   265 --ESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSA 327
              |.:.|..||||..:....|.......|.|:.|.      ||.         :||.:|...::.
 Worm   481 IGEMFQALPQLYLREFLDAQLSNTYRWTETDMLSI------QDY---------DYFARLSDIMAQ 530

  Fly   328 HNISLVANYIMYRAVSAL-NFPLDDRPQLRKRECLERTKELLPTALGELYARQFGTEDGR-IDLD 390
            .:...||||::...|..| .:....|.|...|||:::....      |:..:.:..:..: |||.
 Worm   531 TSRQAVANYLLTVTVWNLKQYSYSPRDQYGWRECVDQISSF------EIGRKMYVDKASQTIDLP 589

  Fly   391 NLYDTLKTALRQSLGAEWLVEGTQRVGQEKLRNLKLQMPTYERPVILKLQLERGNYWQNLRQL-- 453
            .:                         ||.|:|||:...:..|...|:       |..|:.:|
 Worm   590 KI-------------------------QEFLQNLKIDFLSVHRSTPLQ-------YLSNINRLGF 622

  Fly   454 -LGVVQSQRNNRLFEEFLPAPTDPV-----EAYEARVRLRPVQRRLDMG---------------- 496
             :|..:..:|    ||.:..|...|     :.:::.:|:...:|...|.
 Worm   623 YVGFPRRLQN----EELIWKPVSQVSLNETDYFDSMIRVGKAERDYTMSQIGTYLDNDDTTTFPI 683

  Fly   497 -----------------LALLQPPAY-----DPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGL 539
                             ||.::||.|     .|.||   .|::||:...|.:...|
 Worm   684 SDPTMLYNSNVGAIVIPLAFIEPPIYLPGDEVPMYG---IYSSLGITTLQMISKVF--------- 736

  Fly   540 LERDNWDG--QTAWQYHIRSNCFA------RQVDNYLRPNVSATTQLITDSAAINVAFRAYLTWL 596
                 |.|  :|: |.....|.|.      ||....:.|.:.||.:|   :.|...|..:|..|
 Worm   737 -----WQGLDKTS-QLECLDNVFRGFLDANRQRSPNIEPELLATIEL---ADAFKSALYSYAKW- 791

  Fly   597 GFQEPNNDFTKLTKETLPDLNYSNT-ALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQNHTW 660
                 .||.....::|||..:.::: ....|.::...||.|.:.|        |..|.|
 Worm   792 -----QNDHHIHHEKTLPAFDSTDSMRSLMLTFSTMFCSGEGSEP--------GSDYEA------ 837

  Fly   661 TRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCI 694
               ::|....||..|:..|.|...|.:.....|:
 Worm   838 ---MINTVAENSRMFSIHFNCNNSSRLYNRRTCL 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	156/738 (21%)
nep-16	NP_001023203.2	GluZincin	254..>725	CDD:472708	116/555 (21%)