Protein Alignment Nepl14 and nep-5

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 147/740 - (19%)
• Similarity: 275/740 - (37%)
• Gaps: 156/740 - (21%)

  Fly     3 DPC------WTTVFLWLL----------------WLPHLQQNALVSGEDLPPPFQRIYQSEQTVR 45
            :||      .|.|.|.||                |.|. .|.||....|||      .|:::.|:
 Worm    58 EPCTVLAVITTLVILVLLIFALGALGLHDISAFKWEPK-PQKALRIMLDLP------CQTKECVK 115

  Fly    46 RSKAQDMGSHVNKSIDPCVDFYAYACGNWKSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQ 110
            .|  .::...::.|::||.:|:.:.|..:.......::|.     :|:.:.|:...|:...:||:
 Worm   116 YS--AELLELMDSSVNPCENFHHHVCNGFNPRKKDFERLM-----KLINIQEKPDHRKAVNVVRR 173

  Fly   111 AKELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQW-----------AVHHHDYNWLS-V 163
               :...|...:..:..|... ||..|.....||.:..| |           :...:.|.:|: :
 Worm   174 ---MLSKCAMGKTEEIHQVGR-LSSIILPGLPFPLLNNS-WTKPSDPISTSNSSTTYSYPFLTKI 233

  Fly   164 LGGLRLRYGMDILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVAS 228
            |..:.|....|  .|. ||....:.:|.||::.:|.:.:.|....||..||..      .:...|
 Worm   234 LAHIILHNPDD--AGF-VGIKPSSDSEFSLFVVKPFSPVLTNFKFRNMYDILK------RNAPES 289

  Fly   229 ELKSWLALGHDESARLAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELD 293
            .....:.|..|...:| .|::..:.:|              |:..:.|:.....|.|....:.:.
 Worm   290 STNGMIDLEFDRQRQL-NDVIKLQTKL--------------EKIEFKADPEVVNLTEIQRQMPII 339

  Fly   294 -----LDSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVSALNFPLDDRP 353
                 :||::...:.. :.:.||.....|:.::...:|:.....:.|::..|  .:..|...:..
 Worm   340 DWKRLIDSWIPNGYAH-LKEKVYGFNTSYYEEINAIISSTPSETIYNFLFLR--FSFKFLRTEVA 401

  Fly   354 QLRKRECLERTKELLPTALGELYARQFGTEDGRI--DLDNLYDTLKTALRQSLGA-EWLVEGTQR 415
            ...:..||.:....:|   |::..  :|:|:...  .|:.:..|:|..|::||.. :|:......
 Worm   402 SDLEDTCLHQLSTTIP---GKIVL--YGSEEPEALNLLNGMLHTIKDQLKRSLATLKWMDSRGIE 461

  Fly   416 VGQEKLRNLKLQMPTYERPVILKLQ---LERGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPTDPV 477
            ..|:|....|.........:|.:|.   ....||...|:.:|  :...||  :|:..  |..:..
 Worm   462 EAQKKFNKTKTVFGFTGEDLIDELVGKITPESNYISTLQNVL--LWQTRN--MFKSV--AENNVT 520

  Fly   478 EAYEARVRLRPVQRRLDMGLALLQPPAYDPRYGHAIRYATLGVQLAQQLVMAFDDP---HWSVGL 539
            ....:.|.....:..:.:..|||..|.......:...:||:..::..|::..||:.   :.|.|
 Worm   521 VFLNSEVFYSVEKNEITISRALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDG- 584

  Fly   540 LERDNWDGQTAWQYHIRSNCFARQVDNYLRPNVSATTQLITDSAAINVAFRAYLTWLGFQEPNND 604
            ..|:.|:.:|...:.|...||...:.|..             ..::::.:.||           |
 Worm   585 NHRNWWNTETERYFQIIVQCFDGMMQNVF-------------GVSVSIGWNAY-----------D 625

  Fly   605 FTKLTKETLPDLNY-SNTALFFLAYAQEHCSLEEARPRDEQGTPEGYLYSARQNHTWTRLLVNGP 668
            .||....|||.:.. |:.||||.:..:..|:.:          |:.               ||..
 Worm   626 STKEPYATLPGIQQSSDEALFFYSMVKTMCTSD----------PDN---------------VNEA 665

  Fly   669 LRNSVEFASEFRCPIGSPMNPASKC 693
            |.:..:|.|.|:|..|:.|||.:||
 Worm   666 LASVPQFNSAFKCNNGTKMNPPTKC 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	126/659 (19%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:472708	128/661 (19%)