Protein Alignment Nepl14 and nep-12

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001364537.1
• Gene: nep-12 / 173824
• WormBaseID: WBGene00017842
• Length: 832
• Species: Caenorhabditis elegans
• Alignment Length: 727
• Identity: 169/727 - (23%)
• Similarity: 295/727 - (40%)
• Gaps: 143/727 - (19%)

  Fly    54 SHVNKSIDPCVDFYAYACGNW---------KSTLTPQQQLQQQTDRELLLLVEEAVRREDSVIVR 109
            :::|:..:||.|||.:|||.:         :..:|...:::::.||.|..::|:..|...:..::
 Worm   165 NNMNRDANPCEDFYEFACGKYATRKVIAEHEKKVTVLSEMKKEMDRHLKDILEKTSRENTTRSMK 229

  Fly   110 QAKELFKSCVSAQAHQSQQQQHFLSEFINQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMD 174
            .|:..|.||:...:......|..:| .|:..||:|.:..:::  ...|:.| .||.|....||:|
 Worm   230 LAQIYFDSCMDEFSQDDLGVQPLMS-MISNLGGWPLLTNARF--DSIDFQW-EVLAGHLALYGVD 290

  Fly   175 ILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALG-H 238
            .:..:.|..::.:.::|.|..|.|...:..:...|....  .::|.....:....|.|.|.:. .
 Worm   291 GIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPS--SNVYLQYYRQYILSLLSLLGVDME 353

  Fly   239 DESARL---AADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSI---------- 290
            ||:..:   ..||:.||..                    :||.||..|....:||
 Worm   354 DETGVIEYQVDDIIDFERR--------------------IANLTRIELSRNHSSINNMITFGEFK 398

  Fly   291 ----ELDLDSY----VRASFGQDIYKP----VYMAAPEYFRQLKRTVSAHNISLVANYIMYRAVS 343
                :::.|::    :|.:.|:   .|    :.:....||..|...:.:..:|.:.|::|:..||
 Worm   399 RKYDKINWDAFFNEEMRGNLGR---MPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVS 460

  Fly   344 ALNFPLD---DRPQLRKRE--------------CLERTKELLPTALGELYARQFGTEDGRIDLDN 391
            ..:..|.   .:|.|..|:              |:...:|.|...|...||::|.|:..::..::
 Worm   461 NYDMYLPAKYRKPMLDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAED 525

  Fly   392 LYDTLKTALRQS-LGAEWLVEGTQRVGQEKLRNL--KLQMP---TYERPVILK---LQLERGNYW 447
            :...||.|:.|: |.|:|:.|.|:.....||..:  |:..|   ..|..|:|.   ::|....|:
 Worm   526 MIRDLKKAMEQTLLNADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVRLTANQYF 590

  Fly   448 QNLRQLLGVVQSQRNNRLFEEFLPAPTD---PVEAYEARVRLRPVQRRLDMGLALLQPPAYDPRY 509
            .|...|.........::|..  .|:..|   |:.|.:|....  ....:.....:||.|.:.|..
 Worm   591 DNAISLKKAAYRDALSKLHR--TPSLIDWASPIIAVDAFHYF--TGNEIIFPAGILQFPMFVPDA 651

  Fly   510 GHAIRYATLGVQLAQQLVMAFDDPHWSVGLLERDN------WDGQTAWQYHIRSNCFARQVDNYL 568
            .....|..:|:.:..::...:||    :|....|.      |..:|...:..:..||..|..:.:
 Worm   652 PAFSNYGAIGMGIGHEITHGYDD----LGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKI 712

  Fly   569 RPNVSATT-------QLITDSAAINVAFRAYLTWLGFQEPNNDFTKLTKETLPDL-NYSNTALFF 625
            .|......       :.|.|:..:.|||:||       :..:|..|.|:. ||.| ::|...|||
 Worm   713 EPQTGRKVDGKMTIGENIADNGGLRVAFQAY-------QLRSDREKETRR-LPGLTDFSPNQLFF 769

  Fly   626 LAYAQEHCSLEEARPRDEQGTPEGYLYSARQN------HTWTRLLVNGPLRNSVEFASEFRCPIG 684
            ||||...|  |..:|            ||..:      |:.....||.||:|...|:.||.||||
 Worm   770 LAYANTWC--EALKP------------SAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIG 820

  Fly   685 SPMNPASKCIIY 696
            |||||..||.|:
 Worm   821 SPMNPFEKCRIW 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	165/716 (23%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	166/717 (23%)