Protein Alignment Nepl14 and nep-3

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_494679.2
• Gene: nep-3 / 173730
• WormBaseID: WBGene00016778
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 697
• Identity: 148/697 - (21%)
• Similarity: 261/697 - (37%)
• Gaps: 202/697 - (28%)

  Fly    59 SIDPCVDFYAYACGNWK-------STLTPQQQLQQQTDRELLLLVEEAVRREDSVIVRQAKELFK 116
            |:|||.:||..|||.:.       |....:||:.::..|:.|...:.:..:.::    ..|.|::
 Worm    81 SVDPCENFYQAACGKYNEHNVIDGSRTAQKQQIVKRLIRDFLHKNQSSTSKSEN----SMKLLYE 141

  Fly   117 SCVSAQAHQSQQQQHFLSEF---INQNGGFPAVPGSQWAVHHHDYNWLSVLGGLRLRYGMDILIG 178
            .|..|:..:....|:.|.|.   |.:.|.:|.:          |.||    .|.:......:|..
 Worm   142 KCKEAKTIKVLGNQNLLQEIFMNIQKIGSWPVL----------DENW----DGKKFNLNEMLLSL 192

  Fly   179 LRVGY-NYG----NVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVASELKSWLALGH 238
            :|:|. |:|    .::.::....:|:...||.   .|.|||...::                ||:
 Worm   193 IRLGVSNFGFFEIIISSDAFVEIKPARNFPTR---ENLSDIISKVF----------------LGN 238

  Fly   239 DESARLAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREFSNSIELDLDSYVRASFG 303
            .    ...:|.:.|::                            |||:.| ::.:|.|
 Worm   239 G----FQPNITAIEND----------------------------LREYEN-LQRELKS------- 263

  Fly   304 QDIYKPVYMAAPEYFRQLKRTV-SAHNISLVANYIMYRAVSALNFPLDDRPQLRKRECLERTKEL 367
                             |:|.: :..|.||| ||:::..:.::   :.:..:|.:.:|.....:.
 Worm   264 -----------------LERLIQTTPNRSLV-NYLIFNYLKSV---MLEYKRLPEEQCEGVVIDF 307

  Fly   368 LPTALGELYARQFGTEDGRIDLDNLYDTLKTALRQSL-GAEWLVEGTQRVGQEKLRNLKLQM--- 428
            ||.|...::.:.|..::.|..:..:.:.:|......: .:.||.|.:::|..:|::|:|..:
 Worm   308 LPRASTRVFVQNFLDKENRKYVAGMIEDVKMGFIDMIQESTWLNEESKKVAVQKVKNIKSMIGYP 372

  Fly   429 PTYERPVILKLQLERGNYWQ--NLRQLLGVVQSQRNNRLFEEFLPA--PTDP------VEAYEAR 483
            ..:|.|..|....:..|..|  :...::..:|...|.:.. ||:.:  |.||      ..|:...
 Worm   373 DFFEPPGTLDRSFKDLNIEQTDSYHTIVRKIQKFTNEQCM-EFVASEIPLDPRQPILHANAFYQN 436

  Fly   484 VRLRPVQRRLDMGLALLQP----PAYDPRYGHAIRYATLGVQLAQQLVMAFDDPHWSVGLLERDN 544
            ...          ||:|.|    |.:|..:...:..|.:|..||.::..|||  |..:      |
 Worm   437 TNF----------LAILAPVLDDPIFDTTFPRYVNLAVIGNVLAHEIGHAFD--HTGI------N 483

  Fly   545 WDG---QTAW-------QYHIRSNCFARQVDNYLRP------NVSATT-QLITDSAAINVAFRAY 592
            :|.   |..|       :|..|..|..||.|.|..|      |.|.|. ::..|...:..|:|.:
 Worm   484 YDDAGQQRIWLTPEDSEEYGKRLRCLLRQHDEYDDPDFGRNLNGSKTLHEISADRFGVEAAWRTF 548

  Fly   593 LTW--------LGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSLEEARPRDEQGTPEG 649
            ...        :|||                 |::...|:|...|...|     |.||.....
 Worm   549 KKLDLSNESEIVGFQ-----------------NFNIDQLYFRTAALIWC-----RQRDTTDLQ-- 589

  Fly   650 YLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696
              |:.::.|......|||...|..:||..|.||:||||||..||.::
 Worm   590 --YALQREHPTNNFRVNGIYANMPQFAETFNCPLGSPMNPKKKCDLF 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	145/691 (21%)
nep-3	NP_494679.2	M13	82..631	CDD:341056	145/691 (21%)