Protein Alignment Nepl14 and Nep2

DIOPT Version :10

• Sequence 1: NP_651097.1
• Gene: Nepl14 / 42700
• FlyBaseID: FBgn0039023
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_061497288.1
• Gene: Nep2 / 1281326
• VectorBaseID: AGAMI1_002834
• Length: 792
• Species: Anopheles gambiae
• Alignment Length: 764
• Identity: 173/764 - (22%)
• Similarity: 303/764 - (39%)
• Gaps: 206/764 - (26%)

  Fly    47 SKAQDMGSHVNKSIDPCVDFYAYACGNW-KSTLTPQQQLQQQT-----DR---ELLLLVEEAVRR 102
            |||.:   .:::.::||.|||.||||.: |.|:.|.:::...|     ||   :|..||.|.:..
Mosquito   121 SKALE---QMDQEVEPCDDFYNYACGKFVKETVIPDEKVSVNTFSVIGDRLQQQLRSLVSEEISD 182

  Fly   103 EDSVIVRQAKELFKSCVSAQAHQSQQQQHFLSEFINQN---GGFPAVPGSQWAVHHHDYNWLSVL 164
            .::...:.||.|:|.|:    ::::.::..:...::.:   ||:|.:.|..|.: ...::|:..:
Mosquito   183 SEATPFKLAKNLYKLCM----NKTRIEEKGIKPLLDIHEVLGGWPVLKGDSWDL-DSSWSWVKSV 242

  Fly   165 GGLRLR-YGMDILIGLRVGYNYGNVNENSLYLSEPSTLIPTELCTRNRSDIRDSIYEPLEHRVAS 228
            ...|.. |..|......:|.:..|....         :|.|:..:...|  |:.:.:.:|:.:.|
Mosquito   243 KDFRNNGYSTDYFFDFSIGSDLKNSTRR---------IIDTDQASLGIS--REYLVKGMENPIVS 296

  Fly   229 ELKSWLA-----LGHDE--SARLAADILSFEHELCGGMKGGSFESWDAEEQLYLANYTRKTLREF 286
            ...:::.     ||.||  :.|...|.|:||..|      .:....:.:.:...|.|...|::||
Mosquito   297 AYYNYMVDMAVLLGADEERAKRELLDSLNFEMAL------ANISLPNEKRRNATALYNPMTVKEF 355

  Fly   287 S------------NSIELDLDSYVRASFGQDIYKPVYMAAPEYFRQLKRTVSAHNISLVANYIMY 339
            .            |:|..|....:    |::  :.:.::.|.:..||...:......::|||:|:
Mosquito   356 QQRYPYTDWLEYFNAILKDTGIVI----GEE--EVIIVSVPTFMEQLGPLLQNTPKRVMANYVMW 414

  Fly   340 RAVSALNFPLDDRPQLRKR-------------------ECLERTKELLPTALGELYARQFGTEDG 385
            |.....:|.|.::  ||||                   ||::.|...||.::|.||.|::..||.
Mosquito   415 RISGFSSFFLTEK--LRKRQLQYSTALSGKQEQEPRWKECVDITSGSLPISVGALYIRKYFREDS 477

  Fly   386 R---IDLDN-----LYDTLKTALRQSLGAEWLVEGTQRVGQEKLRNLKLQMPTYERPVILKLQLE 442
            :   :|:.|     ..|.||.       .:|:.|.|:....||:..:...:   ..|..|....:
Mosquito   478 KRAALDMVNDIKSVFVDILKK-------VDWMDEVTRVSALEKVSTMATHI---GYPDELMDDAK 532

  Fly   443 RGNYWQNLRQLLGVVQSQRNNRLFEEFLPAPT-----------DPVEAYEARVRL---------- 486
            ...|:::|                 ||.|..|           ...:|:: ::|:
Mosquito   533 IAEYYKDL-----------------EFQPDSTYLNTILYMNKFGTTKAFK-KLRIAVNKTDWITH 579

  Fly   487 -RP---------VQRRLDMGLALLQPP--AYD-PRYGHAIRYATLGVQLAQQLVMAFDDP----- 533
             ||         ::..:.....:||..  :|| |:|   :.|..:|..:..::...|||.
Mosquito   580 SRPAIVNAFYSSIENSIQFPAGILQGQFFSYDRPKY---MNYGAIGFVIGHEITHGFDDQGRQFD 641

  Fly   534 ------HWSVGLLERDNWDGQTAWQYHIRSNCFARQVDNYLRPNV-------SATTQLITDSAAI 585
                  .|         |...|...|..::.|...|..||..|||       :...:.|.|:..|
Mosquito   642 KNGNLVDW---------WQSDTKTAYLEKARCIIEQYGNYTEPNVKLNLNGINTQGENIADNGGI 697

  Fly   586 NVAFRAYLTWLGFQEPNNDFTKLTKETLPDLNYSNTALFFLAYAQEHCSL---EEARPRDEQGTP 647
            ..|:.||..|.....|        ::.||.||.|...:|:|:.||..||:   |..:.|...|.
Mosquito   698 KEAYYAYRRWTEKNGP--------EQRLPGLNLSPEQMFWLSAAQTWCSVYRPETMKMRITTGV- 753

  Fly   648 EGYLYSARQNHTWTRLLVNGPLRNSVEFASEFRCPIGSPMNPASKCIIY 696
                      |:..:..|.||:.|..|||.:|.||:||||||..||.::
Mosquito   754 ----------HSPGQFRVLGPMSNMHEFAKDFNCPVGSPMNPEHKCEVW 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl14	NP_651097.1	M13	60..693	CDD:341056	168/746 (23%)
Nep2	XP_061497288.1	None