DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ECE2

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	737	Identity:	171/737 - (23%)
Similarity:	301/737 - (40%)	Gaps:	122/737 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLP 119
            ::|..:.:.::....||.||::::||.|.|   |...||..|.....  ..:.:|.|.:|...|
Human   147 RVAGKILESLDRGVSPCEDFYQFSCGGWIR---RNPLPDGRSRWNTF--NSLWDQNQAILKHLL- 205

  Fly   120 PQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQW- 183
                .|....:|....:|.:.||.||:.||.......:.|..:::..||        |.....|
Human   206 ----ENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGG--------WNITGPWD 258

  Fly   184 ----VQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDE 244
                ::.|..:...|.......:.|..:.::...|.|...:..| .:|:.......|...:|...
Human   259 QDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGL-FLPSRDYYLNRTANEKVLTA 322

  Fly   245 VYELVQQQVTENLRDWFGM-------DTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAI 302
            ..:.:::         .||       .|.|..:   .::..|.:|......||.::.||
Human   323 YLDYMEE---------LGMLLGGRPTSTREQMQ---QVLELEIQLANITVPQDQRRDEE------ 369

  Fly   303 QAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFK-----MLVEVILESQYPSQVYLRSPE 362
              :||..               |:::||.: :...:|:.     :|..:.|....|..||  ..:
Human   370 --KIYHK---------------MSISELQA-LAPSMDWLEFLSFLLSPLELSDSEPVVVY--GMD 414

  Fly   363 YVKHVVRTVKANNRITVGGYILY----VALNELNQPPEEAPSQ--------------RARQCVQV 409
            |::.|...:.......:..|:::    ...:.|::..|.|..:              |.:.|:..
Human   415 YLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISN 479

  Fly   410 TQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-HVEWMDENDRRAARTRLSQY--R 471
            |.......||.:|.:......:|...:.:.:::..|.||.. .:.||||..|:||:.:....  .
Human   480 TDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDM 544

  Fly   472 VSLPDY--QSLDLTDLQ--FQKSED-YWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRA 531
            :..||:  :..:|.|:.  ::.||| :::.:.....:.:....:.|| ....:|...:....|.|
Human   545 IGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLR-KPPSRDQWSMTPQTVNA 608

  Fly   532 ALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNE 594
            ...|.:..::...|:||||:|...:||:|.:..:|..:...|..||||:|  ::........|..
Human   609 YYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQN 673

  Fly   595 VTMSGYRNASECQRAQYSSYLYNEPGEFRNATR-LREIIADGSGLNLAFNAYLAWLEQQDHKLRP 658
            .:::.:||.:.|...||:.|..|  ||..|..: |.|.|||..||..|:|||.|||.:...
Human   674 ESLAAFRNHTACMEEQYNQYQVN--GERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGE---- 732

  Fly   659 LLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQDAILDSMPLMQHTPERWDVNGPLSNSAE 719
               ::.|..:..||.||||:.|||..|..:    .::..:.|     .|:|.|:.|.|.||||.:
Human   733 ---EQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTD-----PHSPARFRVLGTLSNSRD 789

  Fly   720 FGREFGCALGTPMNSGDKCLVY 741
            |.|.|||.:|:|||.|..|.|:
Human   790 FLRHFGCPVGSPMNPGQLCEVW 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	164/718 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	168/719 (23%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	168/720 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020