DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	788	Identity:	198/788 - (25%)
Similarity:	330/788 - (41%)	Gaps:	141/788 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLFEIQLCDVTEA--RQNHMNRMQMSGN-FPDSREEQLVRQKIATDVQKYMNLSADPCTDFFEYA 78
            |:|...||.:..|  ...::..:...|. .|:...|:....:.|..:...::.|.|||.||:.:|
Human    66 LVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFA 130

  Fly    79 CGQWGRYHKRQLRPDELS--TAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGASMTNVRKVRAF 141
            ||.|.|.|  .:..|:|:  |...:.|.. .|:|::||.:|      ..|..||:.   ||||||
Human   131 CGGWLRRH--AIPDDKLTYGTIAAIGEQN-EERLRRLLARP------GGGPGGAAQ---RKVRAF 183

  Fly   142 YESCVAVEANASERRRFLMKILKDNGGL-------RNVPNSNWQHNRQWVQTLGELRRNYGLDIL 199
            :.||:.:........|.::::::|.||.       |....:.|..||...:..|.    |....|
Human   184 FRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGV----YSAAAL 244

  Fly   200 LGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDE-------VYELVQQQVTENL 257
            ..|.:.|:.:......|...:..||:  .|....||      :||       .|.:..::|...|
Human   245 FSLTVSLDDRNSSRYVIRIDQDGLTL--PERTLYLA------QDEDSEKILAAYRVFMERVLSLL 301

  Fly   258 RDWFGMDTGEAARFAGDIIRFEFELCK-QMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQ 321
                |.|..|  :.|.:|::.|.:|.. .:.|.|                          .|||.
Human   302 ----GADAVE--QKAQEILQVEQQLANITVSEHD--------------------------DLRRD 334

  Fly   322 KGGM----TLTELTSEMGNHLDFKMLVEVILESQY--PSQVYLRSPEYVKHVVRTVKANNRITVG 380
            ...|    ||.:| .::..||.:|.|::.|.:..:  ..:|.|.:.:|::.|.:.:::.....:.
Human   335 VSSMYNKVTLGQL-QKITPHLRWKWLLDQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLH 398

  Fly   381 GYILY---VALNELNQPP--------------EEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQR 428
            .|:::   |.|:|...||              .:.|.:.||.|:....|.|...||.:|......
Human   399 NYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFS 463

  Fly   429 DNAKHDLDAVFNDVIKALEEQF-HVEWMDENDRRAARTRLSQY---RVSLPDY-QSLDLTDLQFQ 488
            ..:|..:..:..|:...|.::. .::|||...|.|||.:| ||   .|..||: ...|..|.:::
Human   464 AASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAKL-QYMMVMVGYPDFLLKPDAVDKEYE 527

  Fly   489 ---KSEDYWRRLEIALKYRSHQQFEALRGNDFGQDAD---------GLDAFEVRAALSPRQQMVL 541
               ..:.|::.:..::::......:.:|     |:.|         .|:|:    .|..:.|||.
Human   528 FEVHEKTYFKNILNSIRFSIQLSVKKIR-----QEVDKSTWLLPPQALNAY----YLPNKNQMVF 583

  Fly   542 VGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNAS 604
            .. |:||...|:..:|:||.|..:|..:...|...:||.|  ::........|.|.:.|.:...:
Human   584 PA-GILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKA 647

  Fly   605 ECQRAQYSSY-LYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSEL 668
            ||....|.:: :||:  .......|.|.|||..||.||::||..|:.:..       .:..|..|
Human   648 ECIVRLYDNFTVYNQ--RVNGKHTLGENIADMGGLKLAYHAYQKWVREHG-------PEHPLPRL 703

  Fly   669 NFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMN 733
            .:|:.|||||.|||..|..:.:|...|..: ..:|.||.:.|.|.:|...||||.|.|...:|||
Human   704 KYTHDQLFFIAFAQNWCIKRRSQSIYLQVL-TDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMN 767

  Fly   734 SGDKCLVY 741
            ...||.|:
Human   768 PAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	183/728 (25%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	185/729 (25%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	186/730 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920