DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Ece1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_006239337.1	Gene:	Ece1 / 94204	RGDID:	620293	Length:	769	Species:	Rattus norvegicus

Alignment Length:	746	Identity:	181/746 - (24%)
Similarity:	304/746 - (40%)	Gaps:	142/746 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELS---TAQQLMETKISEQLQQLLTQP 117
            :.:.:...|:.:.|||.|||.||||.|   .|....||..|   |...|.|..     |.::...
  Rat   106 VTSSILNSMDPTVDPCQDFFSYACGGW---IKANPVPDGHSRWGTFSNLWEHN-----QAIIKHL 162

  Fly   118 LPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQ 182
            |     .|..:.||... :|.:.:|.:|:........|.:.||::::..||        |.....
  Rat   163 L-----ENSTASASEAE-KKAQVYYRACMNETRIEELRAKPLMELIEKLGG--------WNITGP 213

  Fly   183 WVQ-----TLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVR 242
            |.:     ||..:..:|.......:.:..:.:....|.|...:..|              |...|
  Rat   214 WAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGL--------------GLPSR 264

  Fly   243 DEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQM--GEQDIQKPEE----EFPPA 301
            |  |.|   ..|||.:...|            .:.:..:|.|.:  |::|..:|:.    :|..|
  Rat   265 D--YYL---NKTENEKVLTG------------YLNYMVQLGKLLGGGDEDSIRPQMQQILDFETA 312

  Fly   302 IQAQIYGARSRTGQERLRRQKGGMTLTEL--TSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYV 364
            : |.|...:.:...|.|...|  :|..||  .:...|.|.|...:...:|......:.:...||:
  Rat   313 L-ANITIPQEKRRDEELIYHK--VTAAELQTLAPAINWLPFLNAIFYPVEINESEPIVVYDKEYL 374

  Fly   365 KHVVRTVKANNRITVGGYILYVALNE----LNQPPEEAPSQ--------------RARQCVQVTQ 411
            :.|...:.:.::..:..|:::..:.:    |:|..::|..:              |.:.||..|:
  Rat   375 RQVSTLINSTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTE 439

  Fly   412 RLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMDENDRRAARTR------LSQ 469
            ......||.||.:....:::|:....:..::.||.||... ::||||:.||:|:.:      :..
  Rat   440 NNLGFALGPMFVKATFAEDSKNIASEIILEIKKAFEESLSTLKWMDEDTRRSAKEKADAIYNMIG 504

  Fly   470 YRVSLPDYQSLD--------LTDLQFQKSEDY----WRRLEIALKYRSHQQFEALRGNDFGQDAD 522
            |...:.|.:.||        :.||.|:.:..:    ||.....|:...:            :|..
  Rat   505 YPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPN------------RDQW 557

  Fly   523 GLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNH 585
            .:....|.|..||.:..::...|:||||:|....|.:|.:..:|..:...|..||||:|  ::..
  Rat   558 SMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDKD 622

  Fly   586 PQATAQWNEVTMSGYRNASECQRAQYSSYLYN-EPGEFRNATRLREIIADGSGLNLAFNAYLAWL 649
            ......|...::..::..:||...||::|..| ||...|:.  |.|.|||..||..|:.||..|:
  Rat   623 GNLRPWWKNSSVEAFKQQTECMVQQYNNYSVNGEPVNGRHT--LGENIADNGGLKAAYRAYQNWV 685

  Fly   650 EQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQDAILDSMPLMQHTPERWDV 710
            ::..       |::.|..|..|:.||||:.|||..|..:    .::..|.|     .|:|.|:.|
  Rat   686 KKNG-------AEQILPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITD-----PHSPSRFRV 738

  Fly   711 NGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|.||||.||...|.|.||:|||...||.|:
  Rat   739 IGSLSNSKEFSEHFRCPLGSPMNPRHKCEVW 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	175/728 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	177/729 (24%)
Ece1	XP_006239337.1	PepO	105..769	CDD:226118	180/744 (24%)
Ece1	XP_006239337.1	M13	118..767	CDD:189000	178/730 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920