Protein Alignment Nepl13 and MMEL1

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 744
• Identity: 179/744 - (24%)
• Similarity: 312/744 - (41%)
• Gaps: 121/744 - (16%)

  Fly    57 ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQ 121
            |..:.:.|:.:.:||.||:::|||.|.|.|   :.| |.::...:.:. :.::|:.:|...|
Human    98 AARILQNMDPTTEPCDDFYQFACGGWLRRH---VIP-ETNSRYSIFDV-LRDELEVILKAVL--- 154

  Fly   122 HHPNGYSGASMTNVRKVRAFYESCV---AVEANASERRRFLMKILKDNGGLRNVPNSNWQ-HNRQ 182
               ...:......|.|.|..|.||:   .:|...|:.   |:.||:..||        |. ...:
Human   155 ---ENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQP---LLDILEVVGG--------WPVAMDR 205

  Fly   183 WVQTLG---ELRRNYGL-------DILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAE-HCNALAT 236
            |.:|:|   ||.|...|       .:|:.|.|..:.|....:.||..:|.|.:...| :.|..:.
Human   206 WNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSN 270

  Fly   237 RGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPA 301
            |  :|| |.|......|...||:...:.. ::.....|:::. .||..|:.:..:  |:||
Human   271 R--KVR-EAYLQFMVSVATLLREDANLPR-DSCLVQEDMVQV-LELETQLAKATV--PQEE---- 324

  Fly   302 IQAQIYGARSRTGQERLRRQKG--GMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYV 364
             :..:.....|.|.|.|:.|.|  |...|.....:.:.:..|:|.:        .:|.:....|:
Human   325 -RHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPD--------EEVVVYGIPYL 380

  Fly   365 KHVVRTVKANNRITVGGYILY-VALNELNQPPEEAPSQRA----------------RQCVQVTQR 412
            :::...:...:..|:..|::: :.|:.:....:.....|.                |:||.....
Human   381 QNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNS 445

  Fly   413 LFPQVLGEMFQRHV----QRDNAKHDLDAVFNDVIKALEEQFHVEWMDENDRRAARTRLSQYR-- 471
            .....:|.::.|..    .:...:..:|.|....::.|:|   :.||||..::.|:.:....|
Human   446 NMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDE---LGWMDEESKKKAQEKAMSIREQ 507

  Fly   472 VSLPDY------QSLD--LTDLQFQKSED-YWRRLEIALKYRSHQQFEALRGNDFGQDADG---- 523
            :..|||      :.||  .::|.|  ||| |:......||..:.:....||     :..|.
Human   508 IGHPDYILEEMNRRLDEEYSNLNF--SEDLYFENSLQNLKVGAQRSLRKLR-----EKVDPNLWI 565

  Fly   524 LDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQA 588
            :.|..|.|..||.:..::...|:||.|:::...|::|.:..:|..:...:...|||.|.|.....
Human   566 IGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNG 630

  Fly   589 TAQ--WNEVTMSGYRNASECQRAQYSSYLYNEPGE--FRNATRLREIIADGSGLNLAFNAYLAWL 649
            ...  |:..:...:|..|||...||.:|.::...|  ......|.|.|||..|:..|:.|||.|:
Human   631 NMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWM 695

  Fly   650 EQ--QDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNG 712
            .:  :|         :.|..|:.|:.|||||.:||..|.:...:.|| .|:....|:|.::.|.|
Human   696 AEGGKD---------QQLPGLDLTHEQLFFINYAQVWCGSYRPEFAI-QSIKTDVHSPLKYRVLG 750

  Fly   713 PLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|.|.|.|...|.||.||||:..::|.|:
Human   751 SLQNLAAFADTFHCARGTPMHPKERCRVW 779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	175/728 (24%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	175/727 (24%)