DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ece1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001071260.1	Gene:	ece1 / 777750	ZFINID:	ZDB-GENE-061110-100	Length:	752	Species:	Danio rerio

Alignment Length:	754	Identity:	169/754 - (22%)
Similarity:	296/754 - (39%)	Gaps:	164/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYH-----KRQLRP------DELSTAQQLMETKISEQ 109
            :|:.|...::.|.|||.||:.:|||.|.|.:     |.:..|      ..::..:.|:|....:.
Zfish    89 VASAVLGSLDRSVDPCQDFYNFACGGWMRKNPLPEGKSRWGPFSNLWEHNMAVMKNLLENTSMKS 153

  Fly   110 LQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKD----NGGLR 170
            |.:.                     .:|.:.:|::|:    |.|:......|.|:|    .||
Zfish   154 LSRA---------------------EQKAQWYYQACM----NESKIEELGAKPLQDLINQTGG-- 191

  Fly   171 NVPNSNWQHNRQW-----VQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAE- 229
                  |.....|     .:.|..:..|:.......:.:..:.::...|.|...:..|.:...|
Zfish   192 ------WGLKGPWEKDNFQEVLRIVSANFRTSPFFTVFVSTDSKSSNSNIIQVDQSGLGLPSREY 250

  Fly   230 HCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKP 294
            :.|..|       :|.|..........|....|.....:.:...:||.||..|......|..::.
Zfish   251 YLNKTA-------NEKYLNAYLNFLVELGVLLGGSQDTSQKMMEEIIEFETTLANITVPQVERRD 308

  Fly   295 EEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDF-----KMLVEVILESQYPS 354
            ||:....|||:                       ||.: :...:|:     .:...|.|.:..|.
Zfish   309 EEKIYYKIQAK-----------------------ELAT-LAPAIDWMPFLSSVFAPVELNNSEPV 349

  Fly   355 QVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNE----LNQPPEEAPSQ-------------- 401
            .||.:  ||::.|...:...|:..:..|::...:.:    |:|..::|..:
Zfish   350 VVYAK--EYLQKVSELISNTNKSVLNNYMIMKVVRKMVSILDQKFQDAEQRFLEVMYGTKKSCMP 412

  Fly   402 RARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMDENDRRAART 465
            |.:.||..|.......||.:|.:....:::|..::.:.:::..|.|:... |.|||...::||:.
Zfish   413 RWKLCVSDTDSALGFALGALFVKATFSEDSKAFVEDMVSEIKWAFEDSLKTVSWMDPETKKAAKE 477

  Fly   466 RLSQY--RVSLPDY----QSLD--------LTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGND 516
            :....  .|..|.:    :.||        ::||.||...:|:             .|.|....|
Zfish   478 KADAIYNMVGYPKFIMNPKELDKVFNDFDVVSDLYFQNVMNYY-------------NFSARVTAD 529

  Fly   517 FGQDADGLDAFE-----VRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQA 576
            ..:.|...|.:.     |.|..:|.:..:::..|:.|||:||:.:||::.:..:|..:...|..|
Zfish   530 QLRKAPNRDQWSMTPPTVNAYYNPTKNEMVLPAGIFQAPFYNHAWPKAMNFGGIGVVMGHELTHA 594

  Fly   577 FDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSY-LYNEPGEFRNATRLREIIADGSGL 638
            |||:|  ::........|...::..:::.::|...|||:| :.|||  ......|.|.|||..||
Zfish   595 FDDQGRKYDKDGNLAKWWQNSSVEAFQHQTQCMVEQYSNYSINNEP--LNGKHTLGENIADNGGL 657

  Fly   639 NLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQDAILDSMP 699
            |.|:.||:.|:::...       :.:|..|...|.||||:.|||..|..:    .::..|.|
Zfish   658 NAAYKAYVNWIKKNGE-------EASLPALGMNNHQLFFVGFAQVWCSVRTPESSHEGVITD--- 712

  Fly   700 LMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKC 738
              .|:|.|:.|.|.:|||.||...|||...:|||...||
Zfish   713 --PHSPSRFRVIGTISNSHEFSEHFGCKADSPMNPKRKC 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	162/739 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	164/740 (22%)
ece1	NP_001071260.1	PepO	94..752	CDD:226118	167/749 (22%)
ece1	NP_001071260.1	M13	101..750	CDD:189000	166/742 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020